New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 135-138

  Garino, Cédrik ^a   Bihel, Frédéric ^a   Pietrancosta, Nicolas ^a   Laras, Younes ^a   Quéléver, Gilles ^a   Woo, Irene ^b   Klein, Peter ^b   Bain, Jenny ^c   Boucher, Jean Luc ^d   Kraus, Jean Louis ^a  

^a INSERM   (France)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Coumarin isocoumarin; Privileged structure; Substituted benzo c chromen 6 one

Indexed keywords

ASPARTIC PROTEINASE; CHYMOTRYPSIN A; IMINE; KETONE DERIVATIVE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE; SERINE PROTEINASE; TRYPSIN;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; PHYSICAL CHEMISTRY; STRUCTURE ANALYSIS;

ASPARTIC ENDOPEPTIDASES; BENZOPYRANS; CHYMOTRYPSIN; HIV; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE; PROTEIN KINASES; TRYPSIN;

EID: 9644278039     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.018     Document Type: Article

References (15)

1. D.J. Newman, G.M. Cragg, and K.M. Snader J. Nat. Prod. 66 2003 1022 1037
2. R. Murray, J. Mendez, and S. Brown The Natural Coumarins: Occurrence, Chemistry and Biochemistry 1982 John Wiley & Sons New York pp 97-111
3. K.F. Devienne, M.S.G. Raddi, E.A. Varanda, and W. Vilegas Z. Naturforsch. (C) 57 2002 85 88
4. C.M. Kam, J.C. Copher, and J.C. Powers J. Am. Chem. Soc. 109 1987 5044 5045
5. 4 requires C, 50.3; H, 2.4)
6. A.H. Corbett, and A.D.M. Kashuba Curr. Opin. Investig. Drugs 3 2002 384 390
7. J.F. Kerwin, and M. Heller Med. Res. Rev. 14 1994 23 74
8. P. Cohen Nat. Rev. Drug Disc. 1 2002 309 315
9. I. Dorronsoro, A. Castro, and A. Martinez Expert Opin. Ther. Patents 12 2002 1527 1536
10. S.R. Turner, J.W. Strohbach, R.A. Tommasi, P.A. Aristoff, P.D. Johnson, H.I. Skulnick, L.A. Dolak, E.P. Seest, P.K. Tomich, M.J. Bohanan, M.M. Horng, J.C. Lynn, K.T. Chong, R.R. Hinshaw, K.D. Watenpaugh, M.N. Janakiraman, and S. Thaisrivongs J. Med. Chem. 41 1998 3467 3476
11. A. Tuynman, C. Perollier, Y. Frapart, P. Schumann-Bard, V. Collot, S. Rault, and J.L. Boucher Nitric Oxide-Biol. Chem. 9 2003 86 94
12. J.E. Macdonald Annu. Rep. Med. Chem. 31 1996 221 230
13. J. Witherington, V. Bordas, A. Gaiba, N.S. Garton, A. Naylor, A.D. Rawlings, B.P. Slingsby, D.G. Smith, A.K. Takle, and R.W. Ward Bioorg. Med. Chem. Lett. 13 2003 3055 3057
14. J. Bain, H. McLauchlan, M. Elliott, and P. Cohen Biochem. J. 371 2003 199 204
15. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Biochem. J. 351 2000 95 105