History and diagnostic value of antibodies to citrullinated proteins in rheumatoid arthritis

International Journal of Immunopathology and Pharmacology

Volumn 17, Issue 2, 2004, Pages 107-115

  Peene, Isabelle ^a   De Rycke, L ^a   Baeten, D ^a   Hoffman, I ^a   Veys, E M ^a   De Keyser, F ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Anti citrullinated protein antibodies; Rheumatoid arthritis

Indexed keywords

ANTIBODY; AUTOANTIBODY; CITRULLINATED PROTEIN; CITRULLINATED PROTEIN ANTIBODY; EPITOPE; FIBRIN ANTIBODY; FILAGGRIN ANTIBODY; KERATIN ANTIBODY; PERINUCLEAR FACTOR ANTIBODY; PROTEIN; RHEUMATOID FACTOR; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTHROPATHY; CHRONIC INFLAMMATION; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIUM;

EID: 9644272867     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200401700202     Document Type: Review

References (50)

1. Smolen J.S. 1996. Rheumatoid arthritis. In manual of biologic markers of disease. R.N. Maini, W.J. van Venrooij, ed. Kluwer Academic Publishers Dordrecht The Netherlands, p. C.1.1.
2. Arnett F.C., SM. Edworthy, D.A. Bloch, D.J. Mc Shane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, et al. 1988. The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315.
3. Schellekens G.A., BA. de Jong, FH. van den Hoogen, L.B. van de Putte and W.J. van Venrooij. 1998. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 101:273.
4. Girbal-Neuhauser E., J-J. Durieux, M. Arnaud, P. Dalbon, M. Sebbag, C. Vincent, M. Simon, T. Senshu, C. Masson-Bessière, C. Jolivet-Reynaud, M. Jolivet and G. Serre. 1999. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J. Immunol. 162:585.
5. Nienhuis R.L.F. and E.A. Mandema. 1964. A new serum factor in patients with rheumatoid arthritis. Ann. Rheum. Dis. 23:302.
6. Hoet R.M., A.M. Boerbooms, M. Arends, D.J. Ruiter and W.J. van Venrooij. 1991. Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin. Ann. Rheum. Dis. 50:611.
7. Haake A.R. and R.R. Polakowska. Cell death by apoptosis in epidermal biology. 1993. J. Invest. Dermatol. 101:107.
8. Asaga H., M. Yamada and T. Senshu. 1998. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem. Biophys. Res. Comm. 243:641.
9. Union A., L. Meheus, R. Humbel, K. Conrad, G. Steiner, H. Moereels, H. Pottel, G. Serre and F. De Keyser. 2002. Identification of citrullinated rheumatoid arthritis-specific epitopes in natural filaggrin relevant for antifilaggrin autoantibody detection by line immunoassay. Arthritis Rheum. 46:1185.
10. Vincent C., L. Noguiera, M. Sebbag, S. Chapuy Regaud, M. Arnaud, O. Letourneur, D. Rolland, B. Fournie, A. Cantagrel, M. Jolivet and G. Serre. 2002. Detection of antibodies to deiminated rat filaggrin by enzyme linked immunosorbent assay. Arthritis Rheum. 46:2051.
11. Girbal E., V. Sebbag, V. Gomès-Daudrix, M. Simon, C. Vincent and G. Serre. 1993. Characterisation of the rat esophagus epitelium antigens defined by the socalled "anti-keratin antibodies", specific for rheumatoid arthritis. Ann. Rheum. Dis. 52:749.
12. Vincent C., M. Simon, M. Sebbag, E. Girbal-Neuhauser, J.J. Durieux, A. Cantagrel, B. Fournié, B. Mazières and G. Serre. 1998. Immunoblotting detection of autoantibodies to human epidermis filaggrin: a new diagnostic test for rheumatoid arthritis. J. Rheumatol. 25:838.
13. Gomes-Daudrix V., M. Sebbag, E. Girbal, C. Vincent, M. Simon, J. Rakotoarivony, M. Abbal, B. Fournie and G. Serre. 1994. Immunoblotting detection of so-called 'anti keratin antibodies': a new assay for the diagnosis of rheumatoid arthritis. Ann. Rheum. Dis. 53:735.
14. Palosuo T., M. Lukka, H. Alenius, N. Kalkkinen, K. Aho, P. Kurki, R. Heikkilä, M. Nykänen and R. Von Essen. 1998. Purification of filaggrin from human epidermis and measurement of anti-filaggrinautoantibodies in sera from patients with rheumatoid arthritis by an enzyme-linked immunosorbent assay. Int. Arch. Allergy. Immunol. 115:294.
15. Schellekens G.A., H. Visser, B.A.W. de Jong, F.H.J. van den Hoogen, J.M.W. Hazes, F.C. Breedveld and W.J. van Venrooij. 2000. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 43:155.
16. Nogueira L., M. Sebbag, C. Vincent, M. Arnaud, B. Fournie, A. Cantagrel, M. Jolivetand G. Serre. 2001. Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified of deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis. Ann. Rheum. Dis. 60:882.
17. th Vol. 3 Dresden Symposium on autoantibodies. Autoantigens, autoantibodies, autoimmunity Dresden Germany, p.454.
18. Masson-Bessière C., M. Sebbag, E. Girbal-Neuhauser, L. Nogueira, C. Vincent, T. Senshu and G. Serre. 2001. The major synovial targets of the Rheumatoid Arthritis-specific antifilaggrin autoantibodies are deiminated forms of the -and-chains of fibrin. J. Immunol. 166:4177.
19. Masson-Bessière C., M. Sebbag, J-J. Durieux, L. Nogueira, C. Vincent, V.E. Girbal-Neuhauser, R. Durroux, A. Cantagrel and G. Serre. 2000. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum. Clin. Exp. Immunol. 119:544.
20. Nogueira L., S. Chapuy Regaud, A. Constantin, C. Clavel, M. Sebbag, A. Cantagrel, C. Vincent and G. Serre. 2003. Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for early rheumatoid arthritis diagnosis. Arthritis Res. Therapy 5(S): 2.
21. De Rycke L., I. Peene, I.E.A. Hoffman, E. Kruithof, A. Union, L. Meheus, E.M. Veys and F. De Keyser. 2004. Rheumatoid factor and anti-citrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann. Rheum. Dis., (in press).
22. Aho K., T. Palosuo, M. Lukka, P. Kurki, H. Isomaki and R. Von Essen. 1999. Anti-filaggrin antibodies in recent onset arthritis. Scand. J. Rheumatol. 28:113.
23. Goldbach-Mansky R., J. Lee, A. McCoy, J. Hoxworth, C. Yarboro, J.S. Smolen, G. Steiner, A. Rosen, C. Zhang, H.A. Ménard, Z.J. Zhou, T. Palosuo, W.J. van Venrooij, R.L. Wilder, J.H. Klippel, H.R Jr. Schumacher and H.S. El-Gabalawy. 2000. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2:236.
24. Jansen A., E. Van der Horst-Bruinsma, D. Van Schaardenburg, R. Van de Stadt, M. De Koning and B. Dijkmans. 2002. Rheumatoid factor and antibodies to cyclic citrullinated peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis. J. Rheumatol. 29:2074.
25. Forslind K., C. Vincent, G. Serre and B. Svensson. 2000. Antifilaggrin antibodies in early rheumatoid arthritis. Scand. J. Rheumatol. 29:320.
26. Kroot E.J., B.A.W. De Jong, M.A. Van Leeuwen, H. Swinkels, F.H.J. Van den Hoogen, M.van t'hof, L.B. Van de Putte, M.H. Van Rijswijk, W.J. Van Venrooij and P.L. Van Riel. 2000. The prognostic value of anticyclic citrullinated peptide antibody in patients with recent onset rheumatoid arthritis. Arthritis Rheum. 43:1831.
27. Meyer O., C. Labarre, M. Dougados, P. Goupille, A. Cantagrel, A. Dubois, P. Nicaise-Roland, J. Sibilia and B. Combe. 2003. Anticitrullinated protein/peptide antibody assays in early rheumatoid arhtritis for predicting five year radiographic damage. Ann. Rheum. Dis. 62:120.
28. Paimela L., T. Palosuo, K. Aho, M. Lukka, P. Kurki, M. Leirisalo-Repo and R. Von Essen. 2001. Association of autoantibodies to filaggrin with an active disease in early rheumatoid arthritis. Ann. Rheum. Dis. 60:32.
29. Van Jaarsveld C.H.M., E.J. ter Borg, J.W.G. Jacobs, G.A. Schellekens, F.H.J. Gmelig-Meyling, C. van Booma-Frankfort, B.A.W. de Jong, W.J. van Venrooij and J.W.J. Bijlsma. 1999. The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis. Clin. Exp. Rheum. 17:689.
30. Vencovsky J., S. Machacek, L. Sedova, J. Kafkova, J. Gatterova, V. Pesakova and S. Ruzickova. 2003. Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis. Ann. Rheum. Dis. 62:427.
31. Aho K., T. Palosuo, M. Heliovaara, P. Knekt, P. Alha and R. von Essen. 2000. Antifilaggrin antibodies within normal range predict rheumatoid arthritis in a linear fashion. J. Rheumatol. 27:2743.
32. Rantapää Dahlqvist S., B. de Jong, G. Hallmans, G. Wadell, U. Sundin and W. van Venrooij. 2002. Antibodies against citrullinated peptides (CCP) predict the development of rheumatoid arthritis. Arthritis Rheum. 46: S200
33. Nielen M., D. van Schaardenburg, R. van de Stadt, I. van der Horst-Bruinsma, M. de Koning, M. Habibuw, H. Reesink, J. Vandenbroucke and B. Dijkmans. 2002. Autoantibodies in serum of blood donors precede symptoms of rheumatoid arthritis by 1 to 6 years. Arthritis Rheum. 46: S370
34. Lipsky P.E., D.M. van der Heijde, E., W. St Clair, D.E. Furst, F.C. Breed veld, J.R. Kalden, J.S. Smolen, M. Weisman, P. Emery, M. Feldmann, G.R. Harriman and R.N. Maini. 2000. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N. Engl. J. Med. 343:1594.
35. Munoz-Fernandez S., R. Alvarez-Doforno, J.M. Gonzalez-Tarrio, A. Balsa, P. Richi, G. Fontan, J. Gijon-Banosand E. Martin-Mola. 1999. Antiperinuclear factor as prognostic marker in rheumatoid arthritis. J. Rheumatol. 26:2572.
36. Kurki P., R.von Essen, K. Kaarela, H. Isomaki, T. Palosuo and K. Aho. 1997. Antibody to stratum corneum (antikeratin antibody) and antiperinuclear factor: markers for progressive rheumatoid arthritis. Scand. J. Rheumatol. 26:346.
37. Forslind K., C. Vincent, G. Serre and B. Svensson. 2001. Antifilaggrin antibodies in early rheumatoid arthritis may predict radiological progression. Scand. J. Rheumatol. 30:221.
38. Visser H., S. le Cessie, K. Vos, F. Breedveld and J. Hazes. 2002. How to diagnose rheumatoid arthritis early. A prediction model for persistent (erosive) arthritis. Arthritis Rheum. 46:357.
39. Bas S., T.V. Perneger, E. Mikhnevitch, M. Seitz, JM. Tiercy, P. Roux-Lombard and P.A. Guerne. 2000. Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis. Rheumatology. 39:1082.
40. Bas S., T.V. Perneger, M. Seitz, J.M. Tiercy, P. Roux-Lombard and P.A. Guerne. 2002. Diagnostic test for rheumatoid arthritis: comparison of anti-cycliccitrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology. 41:809.
41. Bas S., S. Genevay, O. Meyer and C. Gabay. 2003. Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in diagnosis and prognosis of rheumatoid arthritis. Rheumatology. 42:677.
42. Vincent C., F. De Keyser, C. Masson-Bessière, M. Sebbag, E.M. Veys and G. Serre. 1999. Antiperinuclear factor compared with the so called antikeratin antibodies and antibodies to human epidermal filaggrin, in the diagnosis of arthritides. Ann. Rheum. Dis. 58:42.
43. Hill J.A., S. Southwood, A. Sette, A.M. Jevnikar, D.A. Bell and E. Cairins. 2003. Cutting Edge: the conversion of arginine to citrulline allows for a high affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J. Immunol. 171:538.
44. De Rycke L., N. Van Damme, E. Kruithof, E.I.A. Hoffman, F. Van den Bosch, E.M. Veys and F. De Keyser. 2002. The effect of infliximab on rheumatoid factor and anti-citrullinated cyclic peptide antibodies. Clin. Rheumatol. 21:446.
45. Saraux A., J.M. Berthelot, G. Chales, C. Le Henaff, J.Y. Mary, J.B. Thorel, S. Hoang, M. Dueymes, J. Allain, V. Devauchelle, D. Baron, P. Le Goff and P. Youinou. 2002. Value of laboratory tests in early prediction of rheumatoid arthritis. Arthritis Rheum. 47:155.
46. Bizarro N., G. Mazzanti, E. Tonutti, D. Villalta and R. Tozolli. 2001. Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin. Chem. 47:1089.
47. Palosuo T., R. Tilvis, T. Strandberg and K. Aho. 2003. Filaggrin related antibodies among the aged. Ann. Rheum. Dis. 62:261.
48. Baeten D., I. Peene, A. Union, L. Meheus, M. Sebbag, G. Serre, E.M. Veys and F. De Keyser. 2001. Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: r elevance to anti-filaggrin autoantibodies. Arthritis Rheum. 44:2255.
49. Utz P., T. Gensler and P. Anderson. 2000. Death, autoantigen modifications, and tolerance. Arthritis Res. 2:101.
50. Lee D.M. and P.H. Schur. 2003. Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann. Rheum. Dis. 62:870.