The effects of cucurbitacin E on two lymphocyte models

Pharmaceutical Biology

Volumn 42, Issue 2, 2004, Pages 170-175

  Attard, E ^a   Cuschieri, A ^a   Scicluna Spiteri, A ^a   Brincat, M P ^a  

^a UNIVERSITY OF MALTA   (Malta)

Author keywords

Cell proliferation; Cucurbitacin E; Cytotoxicity; Ecballium elaterium; Lymphocyte activation

Indexed keywords

CUCURBITACIN E; CUCURBITACIN GLYCOSIDE; DNA FRAGMENT; PHYTOHEMAGGLUTININ; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTE ACTIVATION;

ECBALLIUM ELATERIUM;

EID: 9644272816     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200490512124     Document Type: Article

References (33)

1. Attard E, Scicluna-Spiteri A, Grixti M, Cuschieri A (1996): The cytotoxic activity of cucurbitacin E and busulphan on ovarian and stomach cancer cells in vitro: A comparative study. Xjenza 1: 29-34.
2. Basaran A, Basaran N, Baser KH (1993): Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and their suppression by Ecballium elaterium. Fitoterapia: 310-313.
3. Breslin MB, Vedeckis WV (1996): T cell activation: integration of signals from the antigen receptor and costimulatory molecules. Endocrine 5: 15-22.
4. Bulanova EG, Budagyan VM, Yarilin AA, Mazurenko NW (1997): Expression of protooncogenes during lymphocyte activation by growth factors. Biochemistry (Moscow) 62: 1021-1025.
5. Chen HW, Heiniger H, Kanduch AA (1975): Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes. Proc Natl Acad Sci USA 72: 1950-1954.
6. Decker T, Lohmann-Matthes ML (1988): A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosing factor (TNF) activity. J Immun Meth 15: 61-69.
7. Dougherty TF, Berliner DL, Berliner ML (1961): Symposium: Adrenal steroids corticosteroid-tissue interactions. Metabolism 10: 966-989.
8. Elayan HH, Gharaibeh MN, Zmeili SM, Salhab AS (1989): Effects of Ecballium elaterium juice on serum albumin concentration in male rats. Int J Crude Drug Res 27: 227-234.
9. Favel A, Mattras H, Coletti-Previero MA, Zwilling R, Robinson EA, Castro B (1989): Protease inhibitors from Ecballium elaterium seeds. Int J Pept Protein Res 33: 202-208.
10. Feldmann M (1998): Cell cooperation in the antibody response. In: Roitt I, Brostoff J, Male D, eds., Immunology, London, Mosby, pp. 139-150.
11. Freshney RI (1988): Culture of Animal Cells: A Manual of Basic Technique, New York. Alan R Liss, pp. 132-134.
12. Heilman DH, Gambrill MR, Leichner JP (1973): The effect of hvdrocortisone on the incorporation of tritiated thvmidine by human blood lymphocytes cultured with phytohaemagglutinin and pokeweed mitogen. Clin Exp Immunol 15: 203-212.
13. Hemmi H, Kitame F, Ishida N, Kusano G, Kondo Y, Nozoe S (1979): Inhibition of thymidine transport into phytohaemagglutinin-stimulated lymphocytes by triterpenoids from Cimicifuga species. J Pharm Dyn 2: 339-349.
14. Iseki R, Mukai M, Iwata M (1991): Regulation of T lymphocyte apoptosis. Signals for the antagonism between activation- and glucocorticoid-induced death. J Immunol 147: 4286-4292.
15. Munch-Petersen B, Tyrsted G (1977): Induction of thymidine kinases in phytohemagglutinin stimulated human lymphocytes. Biochim Biophys Acta 478: 364-375.
16. Musza LL, Spreight P, McElhiney S, Barrow CJ, Gillum AM, Cooper R, Killar LM (1994): Cucurbitacins, cell adhesion Inhibitors from Conobea scoparioides. J Nat Prod 57: 1498-1502.
17. Naldini A, Carraro F, Silvestri S, Bocci V (1997): Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells. J Cell Physiol 173: 335-342.
18. Ögmundsdottir HM, Zoega GM, Gissurarson SR, Ingolfsdottir K (1998): Anti-proliferative effects of lichen-derived inhibitors of 5-lipoxygenase on malignant cell-lines and mitogen-stimulated lymphocytes. J Pharm Pharmacol 50: 107-115.
19. Ono T, Terayama H, Takaku F, Nakao K (1968): Inhibitory effects of hydrocortisone upon the phytohaemagglutinin-induced RNA-synthesis in human lymphocytes. Biochim Biophys Acta 161: 361-372.
20. Perandones CE, Illera VA, Peckham D, Stunz LL, Ashman RF (1993): Regulation of apoptosis in vitro in mature murine spleen T cells. J Immunol 151: 3521-3529.
21. Polgar PR, Kibrick S, Foster JM (1968): Reversal of PHA-induced blastogenesis in human lymphocyte cultures. Nature 218: 596-597.
22. Rabinovich GA, Modesti NM, Castagna LF, Landa CA, Riera CM, Sotomayor CE (1997): Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a beta-galactoside-binding lectin. J Biochem (Tokyo) 122: 365-373.
23. Rosenau W, Moon H (1962): The inhibitory effect of hydrocortisone on lysis of homologous cells by lymphocytes in vitro. J Immunol 89: 422-426.
24. Sasaki MS, Norman A (1966): Proliferation of human lymphocytes in culture. Nature 210: 913-914.
25. Shohat B, Gitter S, Lavie D (1967): Action of elatericin A on human leukemic and normal lymphocytes. J Natl Cancer Inst 38: 1-9.
26. Sikora E, Bielak-Zmijewska A, Piwocka K, Skierski J, Radziszewska E (1997): Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Biochem Pharmacol 54: 899-907.
27. Stanley DA, Frenster JH, Rigas DA (1971): Localization of 3H-PHA within human lymphocytes and monocytes. In: McIntyre OR, ed., Proceedings of the Fourth Leukocyte Culture Conference, New York, Appleton-Century-Crofts, pp. 1-11.
28. Steward M, Male D (1988): Immunological techniques In: Roitt I, Brostoff J, Male D, eds., Immunology, London, Mosby, pp. 381-394.
29. Ucker DS, Meyers J, Obermiller PS (1992): Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J Immunol 149: 1583-1589.
30. Usher DC, Reiter H (1977): Catabolism of thymidine during the lymphocyte cell cycle. Cell 12: 365-370.
31. Wesselborg S, Janssen O, Kabelitz D (1993): Induction of activation-driven death (apoptosis) in activated but not resting peripheral T-lymphocytes. J Immunol 150: 4338-4345.
32. Witkowski W, Woynarowska B, Konopa J (1984): Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. Biochem Pharm 33: 995-1004.
33. Yesilada E, Tanaka S, Sezik E, Tabata M (1988): Isolation of an anti-inflammatory principle from the juice of Ecballium elaterium. J Nat Prod 51: 504-850.