메뉴 건너뛰기




Volumn 56, Issue 8, 2004, Pages 483-490

Emerging role of P53, Bcl-2 and telomerase activity in Egyptian breast cancer patients

Author keywords

Apoptosis; bcl 2; Mutant p53; Oncogenes; Prognostic factors; Telomerase activity

Indexed keywords

PROTEIN BCL 2; PROTEIN P53; TELOMERASE;

EID: 9644265281     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540400010834     Document Type: Article
Times cited : (17)

References (50)
  • 1
    • 0009945693 scopus 로고
    • General pathology of cancer
    • (El-Balkainy, ed.). Al-Sadekaa Graphics Center (AGC), Cairo
    • El-Balkiny, M. (1991) General pathology of cancer. In: General Pathology of Cancer (El-Balkainy, ed.). Al-Sadekaa Graphics Center (AGC), Cairo.
    • (1991) General Pathology of Cancer
    • El-Balkiny, M.1
  • 2
    • 0028939862 scopus 로고
    • The genetic regulation of apoptosis
    • Wyllie, A. H. (1995) The genetic regulation of apoptosis. Curr. Opin. Genet. Dev. 5, 9-104.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 9-104
    • Wyllie, A.H.1
  • 3
    • 0025255538 scopus 로고
    • Deregulated bcl-2 gene expression selectively prolongs survival of growth factor deprived hemopoietic cell lines
    • Tenz, G., London, L., Hockenbery, D., Alexander, M., Mckearn, J. P., and Prsmeyer, S. J. (1990) Deregulated bcl-2 gene expression selectively prolongs survival of growth factor deprived hemopoietic cell lines. J. Immuno. 52, 3602-3610.
    • (1990) J. Immuno. , vol.52 , pp. 3602-3610
    • Tenz, G.1    London, L.2    Hockenbery, D.3    Alexander, M.4    Mckearn, J.P.5    Prsmeyer, S.J.6
  • 4
    • 9644312046 scopus 로고
    • Bcl-2 modulation of apoptosis produced by anti-cancer drugs: Resistance pathways
    • Minler, A. E., Gregory, C. D., Jackman, G. W., Aherne, G. W., Dive, C., and Hichman, J. A. (1993) Bcl-2 modulation of apoptosis produced by anti-cancer drugs: resistance pathways. Cancer Res. 53, 3320-3326.
    • (1993) Cancer Res. , vol.53 , pp. 3320-3326
    • Minler, A.E.1    Gregory, C.D.2    Jackman, G.W.3    Aherne, G.W.4    Dive, C.5    Hichman, J.A.6
  • 5
    • 0027286802 scopus 로고
    • Bcl-2 expression and embryonic non-haematopoietic tissues
    • Lu, Q. L., Poulsom, R., Wong, L., and Hanby, A. M. (1993) Bcl-2 expression and embryonic non-haematopoietic tissues. J. Pathol. 169. 431-437.
    • (1993) J. Pathol. , vol.169 , pp. 431-437
    • Lu, Q.L.1    Poulsom, R.2    Wong, L.3    Hanby, A.M.4
  • 6
    • 0009895259 scopus 로고
    • Short-term tamoxifen induces the cytoplasmic expression of c-erb-B2 and Bcl-2 in ER-positive human primary breast cancer
    • Johnston, S. R., Salter, J., and Maclennan, K. (1992) Short- term tamoxifen induces the cytoplasmic expression of c-erb-B2 and Bcl-2 in ER-positive human primary breast cancer. Breast 3, 166-169.
    • (1992) Breast , vol.3 , pp. 166-169
    • Johnston, S.R.1    Salter, J.2    Maclennan, K.3
  • 8
    • 0025784539 scopus 로고
    • Wild type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interlukin-6
    • Yonish-Rouach, E., Renitsky, D., Lotem, J., et al. (1991) Wild type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interlukin-6. Nature 352. 354-347.
    • (1991) Nature , vol.352 , pp. 354-347
    • Yonish-Rouach, E.1    Renitsky, D.2    Lotem, J.3
  • 9
    • 0027246692 scopus 로고
    • Regulation by Bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in different complement and defective myeloid leukemic cells
    • Lotem, J., and Sachs, L. (1993) Regulation by Bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in different complement and defective myeloid leukemic cells. Growth Diff. 3, 41-47.
    • (1993) Growth Diff. , vol.3 , pp. 41-47
    • Lotem, J.1    Sachs, L.2
  • 10
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G. B. (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59, 521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 11
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W., and Bacchetti, S. (1997) A survey of telomerase activity in human cancer. Europ. J. Cancer 33, 787-791.
    • (1997) Europ. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 12
    • 0003452668 scopus 로고
    • J. B. Lippincott Co., Philadelphia, USA
    • Am Joint Committee on Cancer (AJCC). (1992) Manual for Staging of Cancer (4th edn.) J. B. Lippincott Co., Philadelphia, USA.
    • (1992) Manual for Staging of Cancer (4th Edn.)
  • 13
    • 0031832116 scopus 로고    scopus 로고
    • Quantitation of bcl-2 protein in bladder cancer tissue by enzyme immunoassay: Comparison with western blot and immunohistochemistry
    • Eissa, S., and Seada, L. (1999) Quantitation of bcl-2 protein in bladder cancer tissue by enzyme immunoassay: comparison with western blot and immunohistochemistry. Clinical Chemistry 44(7), 1423-1429.
    • (1999) Clinical Chemistry , vol.44 , Issue.7 , pp. 1423-1429
    • Eissa, S.1    Seada, L.2
  • 14
    • 0000937143 scopus 로고
    • Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding
    • Bradford, M. M. (1976) Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 722. 28-251.
    • (1976) Anal. Biochem. , vol.722 , pp. 28-251
    • Bradford, M.M.1
  • 16
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim, N. W., Piatyszek, M. A., Prowes, K. R., Harley, C. B., West, M. D., et al. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowes, K.R.3    Harley, C.B.4    West, M.D.5
  • 17
    • 0027524672 scopus 로고
    • Assessing test accuracy and its clinical consequences: A primer for receiver operating characteristic curve analysis
    • Henderson, R. (1993) Assessing test accuracy and its clinical consequences: a primer for receiver operating characteristic curve analysis. Ann. Clin. Biochem. 30, 512-539.
    • (1993) Ann. Clin. Biochem. , vol.30 , pp. 512-539
    • Henderson, R.1
  • 18
    • 0023032508 scopus 로고
    • Epidemiologic programs for computers and calculators. A program for logistic regression on the IBM PC
    • McGee, D. E. (1989) Epidemiologic programs for computers and calculators. A program for logistic regression on the IBM PC. Am. J. Epidemiol. 124, 702-705.
    • (1989) Am. J. Epidemiol. , vol.124 , pp. 702-705
    • McGee, D.E.1
  • 21
    • 0025916196 scopus 로고
    • Prognosis and breast cancer. Recognition of lethal and favorable prognostic types
    • Page, D. L. (1991) Prognosis and breast cancer. Recognition of lethal and favorable prognostic types. Am. J. Surg. Pathol. 15, 334-349.
    • (1991) Am. J. Surg. Pathol. , vol.15 , pp. 334-349
    • Page, D.L.1
  • 22
    • 0028211881 scopus 로고
    • Overview of the biologic markers in breast cancer
    • Jordan, K., and Lippman, M. E. (1994) Overview of the biologic markers in breast cancer. Hematol. Oncol. Clin. North Am. 8, 73-100.
    • (1994) Hematol. Oncol. Clin. North Am. , vol.8 , pp. 73-100
    • Jordan, K.1    Lippman, M.E.2
  • 23
    • 0027945796 scopus 로고
    • Modulation of bcl-2 and ki-67 expression in estrogen-positive human breast cancer by tomoxifen
    • Johanston, S. R. D., MacLennan, K. S., Sacks, N. P. M., Salter, J., Smith, I. E., and Dowsett, M. (1994) Modulation of bcl-2 and ki-67 expression in estrogen-positive human breast cancer by tomoxifen. Eur. J. Cancer 11, 1662-1669.
    • (1994) Eur. J. Cancer , vol.11 , pp. 1662-1669
    • Johanston, S.R.D.1    MacLennan, K.S.2    Sacks, N.P.M.3    Salter, J.4    Smith, I.E.5    Dowsett, M.6
  • 26
    • 84965819899 scopus 로고    scopus 로고
    • Multi-parametric evaluation (SAMBA) of growth fraction (monoclonal ki 67) in breast carcinoma: A correlation of immunodetection in tissue sections and morphological data and estrogen and progesterone receptor immunocytochemical assays
    • Charpin, C., Andrac, L., and Vacheret, H., et al. (1998) Multi-parametric evaluation (SAMBA) of growth fraction (monoclonal ki 67) in breast carcinoma: a correlation of immunodetection in tissue sections and morphological data and estrogen and progesterone receptor immunocytochemical assays. Cancer Res. 48, 4368-4374.
    • (1998) Cancer Res. , vol.48 , pp. 4368-4374
    • Charpin, C.1    Andrac, L.2    Vacheret, H.3
  • 27
    • 0034120314 scopus 로고    scopus 로고
    • Bcl-2 over-expression and hypoxia synergistically act to modulate VEGF expression and in vivo angiogenesis in a breast cancer cell line
    • Biroccio, A., Candiloro, A., Mottolese, M., Sapora, O., Albini, A., Zui, G., and Del Bufalo, D. (2000) Bcl-2 over-expression and hypoxia synergistically act to modulate VEGF expression and in vivo angiogenesis in a breast cancer cell line. FASEB J. 14, 652-660.
    • (2000) FASEB J. , vol.14 , pp. 652-660
    • Biroccio, A.1    Candiloro, A.2    Mottolese, M.3    Sapora, O.4    Albini, A.5    Zui, G.6    Del Bufalo, D.7
  • 28
    • 0036339559 scopus 로고    scopus 로고
    • Multivariate analysis of Bcl-2. Apoptosis, p53 and Her-2/neu in breast cancer: A short-term follow-up
    • El-Ahmady, O., El-Salahy, E., Mahmoud, M., Abdel Wahab, M., Eissa, S., and Khalifa, A. (2002) Multivariate analysis of Bcl-2, Apoptosis, p53 and Her-2/neu in breast cancer: A short-term follow-up. Anticancer Res. 22, 2493-2500.
    • (2002) Anticancer Res. , vol.22 , pp. 2493-2500
    • El-Ahmady, O.1    El-Salahy, E.2    Mahmoud, M.3    Abdel Wahab, M.4    Eissa, S.5    Khalifa, A.6
  • 29
    • 0026055172 scopus 로고
    • Expression of p53 protein in infiltrating and in situ breast carcinomas
    • Walker, R. A., Dearing, S. J., Lane, D., and Valley, J. M. (1991) Expression of p53 protein in infiltrating and in situ breast carcinomas. J. Pathol. 165, 203-211.
    • (1991) J. Pathol. , vol.165 , pp. 203-211
    • Walker, R.A.1    Dearing, S.J.2    Lane, D.3    Valley, J.M.4
  • 30
    • 0035198905 scopus 로고    scopus 로고
    • The relation Ship between the expression of p53/ Bcl-2 and histopathological criteria in breast invasive ductal carcinomas
    • Gursan, N., Karakok, M., Sari, I., and Gursan, M. S. (2001) The relation Ship between the expression of p53/ Bcl-2 and histopathological criteria in breast invasive ductal carcinomas. Int. J. Clin. Pract. 55(9), 589-590.
    • (2001) Int. J. Clin. Pract. , vol.55 , Issue.9 , pp. 589-590
    • Gursan, N.1    Karakok, M.2    Sari, I.3    Gursan, M.S.4
  • 32
    • 0032475456 scopus 로고    scopus 로고
    • Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk
    • Rohan, T. E., Hartwick, W., Miller, A. B., and Kandel, R. A. (1998) Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk. J. Natl. Cancer Inst., 90(17), 1247-1248.
    • (1998) J. Natl. Cancer Inst. , vol.90 , Issue.17 , pp. 1247-1248
    • Rohan, T.E.1    Hartwick, W.2    Miller, A.B.3    Kandel, R.A.4
  • 33
    • 0029866564 scopus 로고    scopus 로고
    • The reactivation of telomerase activity in cancer progression
    • Shay, J. W., and Wright, W. E. (1996) The reactivation of telomerase activity in cancer progression. Trends Genet. 12, 129-131.
    • (1996) Trends Genet. , vol.12 , pp. 129-131
    • Shay, J.W.1    Wright, W.E.2
  • 35
    • 0031905596 scopus 로고    scopus 로고
    • Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma
    • Yashima, K., Milchrub, S., Gollahon, L. S., Miatra, A., Saboorian, M. H., Shay, J. W., and Gazdar, A. F. (1998) Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma. Clin. Cancer Res. 4(1), 229-234.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.1 , pp. 229-234
    • Yashima, K.1    Milchrub, S.2    Gollahon, L.S.3    Miatra, A.4    Saboorian, M.H.5    Shay, J.W.6    Gazdar, A.F.7
  • 36
    • 0029867398 scopus 로고    scopus 로고
    • Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?
    • Greaves, M. (1996) Is telomerase activity in cancer due to selection of stem cells and differentiation arrest? Trends Genet. 12, 127-128.
    • (1996) Trends Genet. , vol.12 , pp. 127-128
    • Greaves, M.1
  • 37
    • 0029008234 scopus 로고
    • Flowcytometric analysis of apoptosis and Bcl-2 in human solid neoplasm
    • Steck, K., McDonnell, T. J., and El-Naggar, A. K. (1995) Flowcytometric analysis of apoptosis and Bcl-2 in human solid neoplasm. Cytomety 20, 154-161.
    • (1995) Cytomety , vol.20 , pp. 154-161
    • Steck, K.1    McDonnell, T.J.2    El-Naggar, A.K.3
  • 39
    • 0034884829 scopus 로고    scopus 로고
    • P21/WAF1/CIP1 expression in invasive ductal breast carcinoma: Relationship to p53, proliferative rate and survival at 5-years
    • Domagala, W., Welcjer, M., Chosia, M., Karbowniczek, M., Harezga, B., Bartkova, J., Bartek, J., and Osborn, M. (2001) P21/WAF1/CIP1 expression in invasive ductal breast carcinoma: relationship to p53, proliferative rate and survival at 5-years. Virchows Arch. 239(2), 132-140.
    • (2001) Virchows Arch. , vol.239 , Issue.2 , pp. 132-140
    • Domagala, W.1    Welcjer, M.2    Chosia, M.3    Karbowniczek, M.4    Harezga, B.5    Bartkova, J.6    Bartek, J.7    Osborn, M.8
  • 41
    • 0031800113 scopus 로고    scopus 로고
    • Differential expression of VEGF mRNA vs. protein isoform expression in human breast cancer and relation ship to eIF-4E
    • Scott, P. A. E., Smith, K., Poulsom, R., DeBenedetti, A., Bicknell, R., and Harris, A. L. (1998) Differential expression of VEGF mRNA vs. protein isoform expression in human breast cancer and relation ship to eIF-4E. Br. J. Cancer 77, 2120-2128.
    • (1998) Br. J. Cancer , vol.77 , pp. 2120-2128
    • Scott, P.A.E.1    Smith, K.2    Poulsom, R.3    DeBenedetti, A.4    Bicknell, R.5    Harris, A.L.6
  • 42
    • 0028297039 scopus 로고
    • Mammalian telomerase dynamics: Healing, fragmentation shortening and stabilization
    • Greider, C. W. (1994) Mammalian telomerase dynamics: healing, fragmentation shortening and stabilization. Curr. Opin. Genet. Dev. 4. 203-211.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 203-211
    • Greider, C.W.1
  • 43
    • 0034868104 scopus 로고    scopus 로고
    • Quantitative determination of telomerase activity in breast cancer and benign breast diseases
    • Simickova, M., Nekulova, M., Pecen, L., Cernoch, M., Vagundova, M., and Pacovsky, Z. (2001) Quantitative determination of telomerase activity in breast cancer and benign breast diseases. Neoplasma 48(4), 267-273.
    • (2001) Neoplasma , vol.48 , Issue.4 , pp. 267-273
    • Simickova, M.1    Nekulova, M.2    Pecen, L.3    Cernoch, M.4    Vagundova, M.5    Pacovsky, Z.6
  • 44
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T., and Reed, J. C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 45
    • 0036479770 scopus 로고    scopus 로고
    • Telomerase activity in microdissected human breast cancer tissues: Association with p53, p21 and outcome
    • Mueller, C., Riese, U., Koosmehl, H., Dahse, R., Claussen, U., and Ernst, G. (2002) Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome. Int. J. Oncol. 20(2), 385-390.
    • (2002) Int. J. Oncol. , vol.20 , Issue.2 , pp. 385-390
    • Mueller, C.1    Riese, U.2    Koosmehl, H.3    Dahse, R.4    Claussen, U.5    Ernst, G.6
  • 46
    • 0001934324 scopus 로고    scopus 로고
    • Telomeres and aging
    • (Blackburn E. H and Greider C. W. eds). Cold Spring Harbor Laboratory Press, Plainview, NY
    • Harley, C. B. Telomeres and aging. In: Telomeres (Blackburn E. H and Greider C. W. eds). p247. Cold Spring Harbor Laboratory Press, Plainview, NY.
    • Telomeres , pp. 247
    • Harley, C.B.1
  • 47
    • 0030917098 scopus 로고    scopus 로고
    • Proliferative life span checkpoints: Cell-type specifically and influence on tumor biology
    • Wynford-Thomas, D. (1997) Proliferative life span checkpoints: cell-type specifically and influence on tumor biology. Eur. J. Cancer 33, 716-726.
    • (1997) Eur. J. Cancer , vol.33 , pp. 716-726
    • Wynford-Thomas, D.1
  • 48
    • 0009895260 scopus 로고
    • Breast cancer update: Prognostic profile markers. Division of specialty lab. INC. How to use prognostic factors in ANN breast cancer patients
    • McGuire, W. L., Tandon, A. K., Allerd, D., Chamness, G. C. and Clark, G. M. (1992) Breast cancer update: Prognostic profile markers. Division of specialty lab. INC. How to use prognostic factors in ANN breast cancer patients. J. Natl. Cancer Inst. 82, 1451-1453.
    • (1992) J. Natl. Cancer Inst. , vol.82 , pp. 1451-1453
    • McGuire, W.L.1    Tandon, A.K.2    Allerd, D.3    Chamness, G.C.4    Clark, G.M.5
  • 49
    • 0028346799 scopus 로고
    • Expression of bcl-2 gene confers multidrug resistance to chemotherapy-induced cell death
    • Hsu, B., Marin, M. C., Brisby, S., McConnel, K., and McDonnell, T. J. (1994) Expression of bcl-2 gene confers multidrug resistance to chemotherapy-induced cell death. Cancer Bull. 46, 125-129.
    • (1994) Cancer Bull. , vol.46 , pp. 125-129
    • Hsu, B.1    Marin, M.C.2    Brisby, S.3    McConnel, K.4    McDonnell, T.J.5
  • 50
    • 9644298989 scopus 로고    scopus 로고
    • Inhibition of cell growth, and telomerase activity of breast cancer cells in vitro by zidovudine
    • Melena, S. M., Holl, J. F., and Pogo, B. (1998) Inhibition of cell growth, and telomerase activity of breast cancer cells in vitro by zidovudine. Clin. Cancer Res. 89, 1874-1881.
    • (1998) Clin. Cancer Res. , vol.89 , pp. 1874-1881
    • Melena, S.M.1    Holl, J.F.2    Pogo, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.