Reciprocal relationship between a Ph-negative clone with trisomy 8 associated with severe myelodysplasia and a Ph-positive clone following imatinib treatment in a patient with accelerated-phase chronic myelogenous leukemia (CML) [6]

American Journal of Hematology

Volumn 77, Issue 4, 2004, Pages 420-

  Patchenko, Paulina ^a   Klepfish, Abraham ^a   Trakhtenbrot, Luba ^b   Rothman, Rachel ^b   Rachmilewitz, Eliezer A ^a  

^a WOLFSON MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB;

ADULT; ANEMIA; BONE MARROW HYPOPLASIA; CASE REPORT; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; DISEASE SEVERITY; HUMAN; LETTER; LEUKOPENIA; MALE; MOLECULAR CLONING; MYELODYSPLASIA; NEUTROPENIA; PRIORITY JOURNAL; THROMBOCYTOPENIA; THROMBOCYTOSIS; TRISOMY 8;

CHROMOSOMES, HUMAN, PAIR 8; CLONE CELLS; HUMANS; LEUKEMIA, MYELOID, AGGRESSIVE-PHASE; LEUKEMIA, MYELOID, PHILADELPHIA-NEGATIVE; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PHILADELPHIA CHROMOSOME; PIPERAZINES; PYRIMIDINES; TRISOMY;

EID: 9644262759     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20226     Document Type: Letter

References (5)

1. O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
2. Braziel RM, Launder TM, Druker BJ, et al. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients; 14 months' experience. Blood 2002;100:435-441.
3. - cells in some CML patients in cytogenetic remission to imatinib restoration of polyclonal hematopoiesis in the majority. Blood 2003;101:1941-1949.
4. Royer-Pokora B, Hildebrandt B, Redmann A, et al. Simultaneous occurrence of a t(9;22) (Ph) with a t(2;11) in a patient with CML and emergence of a new clone with the t(2;11) alone after imatinib mesylate treatment. Leukemia 2003;17:807-810.
5. Andersen MK. Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Spotlight correspondence. Leukemia 2002;16:1390-1395.