Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right-heart dysfunction, and refractory hypoxemia after cardiothoracic surgery [1]

Journal of Thoracic and Cardiovascular Surgery

Volumn 128, Issue 6, 2004, Pages 949-950

  Muzaffar, Saima ^a   Shukla, Nilima ^a   Angelini, Gianni D ^a   Jeremy, Jamie Y ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ILOPROST; NITRIC OXIDE; PEROXYNITRITE; PROSTACYCLIN; REACTIVE NITROGEN SPECIES; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANTIOXIDANT ACTIVITY; CELL MIGRATION; CELL PROLIFERATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; ENZYME INHIBITION; GRAFT REJECTION; HEART DISEASE; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPOXEMIA; INFLAMMATION; LETTER; LEUKOCYTE ADHERENCE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; THORAX SURGERY; THROMBOCYTE ADHESION; UPREGULATION;

ANOXEMIA; ANTIHYPERTENSIVE AGENTS; CARDIAC SURGICAL PROCEDURES; EPOPROSTENOL; HUMANS; HYPERTENSION, PULMONARY; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, LEFT;

EID: 9644258875     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2004.05.035     Document Type: Letter

References (8)

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2. S. Muzaffar, J.Y. Jeremy, G.D. Angelini, K. Stuart-Smith, N. Shukla The role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries Thorax 58 2003 598 604
3. 2α in cultured porcine pulmonary artery vascular smooth muscle cells Br J Pharmacol 141 2004 488 496
4. Muzaffar S, Shukla N, Angelini GD, Jeremy JY. Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. Circulation. 2004;110:1140-7.
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8. D.J. Lefer, D.N. Granger Oxidative stress and cardiac disease Am J Med 109 2000 315 323