Vasorelaxant effects of the chloroformic crude extract of Bupleurum fruticosum L. (Umbelliferae) roots on rat thoracic aorta

Journal of Ethnopharmacology

Volumn 96, Issue 1-2, 2005, Pages 93-97

  Testai, Lara ^a   Silvio, Chericoni ^a   Ammar, Bader ^b   Luisa, Pistelli ^a   Vincenzo, Calderone ^a   Martinotti, Enrica ^a  

^a UNIVERSITY OF PISA   (Italy)

^b AL ZAYTOONAH UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Bupleurum fruticosum; Rat aorta; Ryanodine sensitive Ca 2+ channels; Umbelliferae; Vasorelaxing response

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENYLATE CYCLASE; BUPLEURUM FRUTICOSUM EXTRACT; CAFFEINE; CALCIUM CHANNEL; CALCIUM ION; CHLOROFORM; CYCLOPIAZONIC ACID; ENZYME INHIBITOR; GUANYLATE CYCLASE; NIFEDIPINE; NORADRENALIN; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; RYANODINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; NONHUMAN; PLANT ROOT; RAT; SARCOPLASMIC RETICULUM; THORACIC AORTA; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; BUPLEURUM; CHLOROFORM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; MUSCLE, SMOOTH, VASCULAR; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR; SOLVENTS; VASODILATION; VASODILATOR AGENTS;

EID: 9644258594     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2004.08.024     Document Type: Article

References (22)

1. H. Abe, M. Sakaguchi, S. Ariki, and S. Odoshima Actions of saikosaponins isolated from Bupleurum falcatum effects of saikosaponins on liver function Planta Medica 40 1980 366 372
2. M. Ballero, and I. Fresu Le piante di uso officinale nella Barbagia di Seui (Sardegna centrale) Fitoterapia 64 1993 141 150
3. B. Baragatti, V. Calderone, L. Testai, E. Martinotti, S. Chericoni, and I. Morelli Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae) Journal of Ethnopharmacology 79 2002 369 372
4. S. Chericoni, L. Testai, V. Calderone, G. Flamini, P. Nieri, I. Morelli, and E. Martinotti The xanthones Gentiacaulein and Gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana Planta Medica 69 2003 770 772
5. S. Chericoni, L. Testai, E. Campeol, V. Calderone, I. Morelli, and E. Martinotti Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study Journal of Ethnopharmacology 91 2004 263 266
6. L. Chiang, L.T. Ng, L. Liu, D. Shieh, and C. Lin Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species Planta Medica 69 2003 705 709
7. C.D. Ferris, and S.H. Snyder Inositol phosphate receptors and calcium disposition in the brain Journal Neuroscience 12 1992 1567 1574
8. M.I. Kotlikoff Calcium-induced calcium release in smooth muscle: the case for loose coupling Progress in Biophysics and Molecular Biology 83 2003 171 191
9. I. Lorente, M.A. Ocete, A. Zarzuelo, M.M. Cabo, and J. Jimenez Bioactivity of the essential oil of Bupleurum fruticosum Journal Natural Products 52 1989 267 272
10. 2+ release channels and their regulation by endogenous effectors Annual Review Physiology 56 1994 485 508
11. V. Picci, A.D. Manunta, and A.D. Atzei Essenze, profumi, piante off., aromi, sapori, cosmetici Aerolsol 56 1974 224 244
12. L. Pistelli, A.R. Bilia, A. Marsili, N. De Tommasi, and A. Manunta Triterpenoid saponins from Bupleurum fruticosum Journal Natural Products 56 1993 240 244
13. L. Pistelli, A.R. Bilia, A. Bertoli, I. Morelli, and A. Marsili Phenylpropanoids from Bupleurum fruticosum Journal Natural Products 58 1995 112 116
14. L. Pistelli, A. Bertoli, A.R. Bilia, and I. Morelli Minor constituents from Bupleurum fruticosum roots Phytochemisty 41 1996 1579 1582
15. F. Protasi, A. Shtifman, F.J. Julian, and P.D. Allen All three ryanodine receptor isoforms generate rapid cooling responses in muscle cells American Journal of Physiology Cell Physiology 286 2004 662 670
16. J. Purmova, and L. Opletal Phytotherapeutic aspects of diseases of the cardiovascular Ceska a Slovenska Farmacie 44 1995 246 251
17. H. Shima, and M.P. Blaustein Modulation of evocked contractions in rat arteries by ryanodine, thapsigargin, and cyclopiazonc acid Circulation Research 70 1992 968 977
18. D.Y. Sui, X.F. Yu, S.C. Qu, Z.Z. Lu, L. Wang, and M.Q. Chen Protective effect of Panax quinquefolium 20 s-proto-panaxdiolsaponins on acute myocardial infarction in dogs Zhongguo Zhong Yao Za Zhi 26 2001 416 419
19. + currents in guinea-pig smooth muscle cells British Journal of Pharmacology 107 1992 134 140
20. 2+ release in smooth muscle cells American Journal Physiology Cell Physiology 286 2004 538 546
21. M. Yamamoto, A. Kumagai, and Y. Yamamura Structure and actions of saikosaponins isolated from Bupleurum falcatum L. Anti-inflammatory action of saikosaponins. Arzneimittelforschung 25 1975 1021 1023
22. 2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states Pharmacological Reviews 49 1997 1 51