Quantitative HIV-1 RNA as a marker of clinical stability and survival in a cohort of 302 patients with a mean CD4 cell count of 300 x 106/l

AIDS

Volumn 10, Issue 11, 1996, Pages

  Ruiz, Lidia ^a   Romeu, Joan ^a   Clotet, Bonaventura ^a   Balagué, Montserrat ^a   Cabrera, Cecilia ^a   Sirera, Guillem ^a   Ibáñez, Angela ^a   Martínez Picado, Javier ^a   Raventós, Antoni ^a   Tural, Cristina ^a   Segura, Antònia ^a   Foz, Màrius ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Disease progression; Natural history; Prognosis; Surrogate markers; Survival; Viral load

Indexed keywords

CD4 ANTIGEN; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COHORT ANALYSIS; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK; SURVIVAL;

EID: 9544258289     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199609000-00001     Document Type: Article

References (16)

1. Choi S, Lagakos SW, Schooley RT, Volberding PA: CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine. Ann Intern Med 1993, 118:674-680.
2. Lacey JN, Forbers MA, Waugh MA, Cooper EH, Hambling MH: Serum beta 2-microglobulin and human immunodeficiency virus type-1. N Engl J Med 1990, 322:166-172.
3. Kramer A, Wiktor SZ, Fuchs D, et al.: Neopterin: a predictive marker of acquired immune deficiency virus infection. J Acquir Immune Defic Syndr 1989, 2:291-296.
4. Lelie PN, Reesink HW, Bakker E, Huisman JG, Ten Veen J: Clinical importance of HIV antigen and anti-HIV core markers in persons infected with HIV [letter]. N Engl J Med 1988, 318:1204-1205.
5. Ho DD, Meumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126.
6. Wei X, Ghosh SK, Taylor ME, et al.: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995, 373:117-122.
7. Mulder J, McKinney N, Christopherson C, Sninsky J, Greefield L, Kwok S: Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA plasma: application to acute retroviral infection. J Clin Microbiol 1994, 32:292-303.
8. Horn T, Urdea M: Forks and combs and DNA: the synthesis of branched oligodeoxyribonucleotides. Nucleic Acids Res 1989, 17:6959-6967.
9. Kievits T, van Gemen B, van Strijp D, et al.: NASBA isothermal enzymatic in vitro nucleic acids amplification optimized for the diagnosis of HIV-1 infection. J Virol Methods 1991, 35:273-286.
10. Volberding PA: HIV quantification: clinical applications. Lancet 1996, 347:71-73.
11. Mellors JW, Kingsley LA, Rinaldo CR, et al.: Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995, 122:573-579.
12. O'Brien WA, Hartigan PM, Martin D, et al.: Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996, 334:426-431.
13. Verhofstede C, Reniers S, Van Wanzeele F, Plum J: Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease. AIDS 1994, 8:1421-1427.
14. Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakobsen PH, Gerstoft J: Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996, 10:167-173.
15. Centers for Disease Control: 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescent and adults. MMWR 1992, 41:1-19.
16. Loannidis JPA, Cappelleri JC, Lau J, Sacks HS, Skolnik PR: Predictive value of viral load measurements in asymptomatic untreated HIV-1 infection: a mathematical model. AIDS 1996, 10:255-262.