Repeated fasting and refeeding with 20:5, n-3 Eicosapentaenoic Acid (EPA): A novel approach for rapid fatty acid exchanges and its effect on blood pressure, plasma lipids and hemostasis

Journal of Human Hypertension

Volumn 10, Issue SUPPL. 3, 1996, Pages

  Yosefy, C ^a   Viskoper, J R ^a,d   Varon, D ^b   Ilan, Z ^a   Pilpel, D ^a   Lugassy, G ^a   Schneider, R ^a   Savyon, N ^b   Adan, Y ^c   Raz, A ^c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d BARZILAI MEDICAL CENTER   (Israel)

Author keywords

Blood pressure; DHA; EPA; Fasting; PUFA; Refeeding

Indexed keywords

ALSEPA; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID; FIBRINOGEN; FISH OIL; HIGH DENSITY LIPOPROTEIN; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DRUG USE; EXTRACELLULAR MATRIX; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMOSTASIS; HUMAN; HYPERTENSION; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; METABOLIC PARAMETERS; ORAL DRUG ADMINISTRATION; PHOSPHOLIPID BLOOD LEVEL; REFEEDING; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; BLOOD PRESSURE; EICOSAPENTAENOIC ACID; FASTING; FATTY ACIDS; FEMALE; FOOD; HEMOSTASIS; HUMANS; HYPERTENSION; LIPIDS; MALE; MIDDLE AGED; OBESITY; TIME FACTORS; TRIGLYCERIDES;

EID: 9544242835     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (34)

1. Bonaa KH et al. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. N Engl J Med 1990; 322: 795-801.
2. Engler MB, Marguerite ME, Ursell PC. Varorelaxant properties of n-3 PUFA in aorta from spontaneously hypertensive and normotensive rats. J Cardiovascular Risk 1994; 1: 75-80.
3. Levinson PD et al. Effects of n-3 fatty acids in essential hypertension. Am J Hypertens 1990; 3: 754-760.
4. Kestin K et al. n-3 fatty acid of marine origin lowers systolic blood pressure and triglycdrides but raises LDL cholesterol compared with n-3 and n-6 fatty acids from plants. Am J Clin Nutr 1990; 51: 1028-1034.
5. Appel LJ et al. Does supplementation of diet with fish oil reduce blood pressure? Arch Int Med 1993; 153 (12): 1429-1438.
6. Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 1993; 88: 523-533.
7. Raz A, Przedecki F, Kamin-Belsky N. A paradigm for rapid and substantial exchange of tissue arachidonic acid for eicosapentaenoic acid. 9th International Conference on Prostaglandins and Related Compounds. Florence, Italy 1994.
8. Blonk CM et al. Dose-response effects of fish-oil supplementation in healthy volunteers. Am J Clin Nutr 1990; 52: 120-127.
9. Marangoni F et al. Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DMA) ethyl esters and prolonged washout. Biochimica et Biophysica Acta 1993; 1210: 52-62.
10. Reis GJ et al. Effects of two types of fish oil supplements on serum lipids and plasma phospholipids fatty acids in coronary artery disease. Am J Cardiology 1990; 66: 1171-1175.
11. Decaterina R et al. Vascular prostacyline is increased in patients ingesting w-3 polyunsaturated fatty acids before coronary artery bypass graft surgery. Circulation 1990; 82: 428-438.
12. Bennett JS. Mechanisms of platelet adhesion and aggregation an update. Hospital Practice Off ed 1992; 27 (4): 124-138.
13. Varon D, Dardik R, Savyon N. Thrombosis state: a new method and devise for quantitative analysis of platelet interaction with extra cellular matrix under defined shear conditions - thrombosis and hemostasis. 15th Congress of the International Society of Thrombosis and Hemostasis. Jerusalem, Israel, June 11-16, 1995 (Abstract 563).
14. Budowski P. Oils rich in omega-3 fatty acids - health implications. Harefuah 1995; 128 (2): 121-125.
15. Shrapnel WS et al. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Aust 1992; 156 Suppl: S9-S16.
16. Sanders T et al. Triglyceride lowering effect of marine polyunsaturates in patients with hypertriglyceridemia. Atherosclerosis 1985; 5: 459-465.
17. Schacky CV, Fischer S, Weber PC. Long term effects of dietary marine w-3 fatty acids upon plasma and cellular lipids, platelet function and eidosanoid formation in humans. J Clin Investigation 1985; 76: 1626-1631.
18. Tremoli E et al. Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl-ester ingestion by healthy volunteers. Am J Clin Nutr 1995; 61: 607-613.
19. Goto YH, Tamachi H, Moriguchi EH. Eicosapentaenoic acid and atherosclerosis. Prostagland Leuk Essen Fatty Acid 1993; 48: 337-342.
20. Howe PRC et al. Effects of dietary sodium and fish oil on blood pressure development in stroke-prone spontaneously hypertensive rats. J Hypertens 1991; 9: 639-644.
21. Hallag H, Smith TWAL. Modulation of dihydropyridine sensitive calcium channels in heart cells by fish oil fatty acids. Proc Natl Acad Sci 1992; 89: 1760-1764.
22. Holian O, Nelson R. Action of long chain fatty acid on protein kinase C activity. Comparison of omega-6 and omega-3 fatty acid. Anticancer Res 1992; 12: 975-980.
23. McVeigh GE et al. Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) Diabetes Mellitus. Diabetologia 1993; 36: 33-38.
24. Egan BM, Stepniakowski K. Effects of enalapril on the hyperinsulinemic response to severe salt restriction in obese young men with mild hypertension. Ann J Cardiol 1993; 72: 53-57.
25. Olivieri O et al. w-3 PUFA supplementation and membranes cation transport in mild essential hypertensive patients. Seventh European Meeting on Hypertension. Milan, Italy, June 1995. (Abstract 602).
26. Gapinski JP et al. Preventing restenosis with fish oil following coronary angioplasty: a meta-analysis. Arch Intern Med 1993; 153: 1595-1601,
27. Svaneborg N et al. The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoprotein in healthy subjects. Lipids 1994; 29: 145-147.
28. Yin K, Croft KD, Beilin LJ. Effect of pure eicosapentaenoic acid feeding on blood pressure and vascular reactivity in spontaneously hypertensive rats. Clin Exp Pharmacology Physiol 1988; 15: 275-280.
29. Mori TA et al. The interrelationship between blood pressure, platelet aggregation and thromboxane following dietary fish and fish oil in men at risk of heart disease. 15th Scientific Meeting of the International Society of Hypertension. March 1994, Melbourne, Australia (Abstract 395).
30. Reis GJ et al. Randomised trial of fish oil for prevention of restenosis after coronary angioplasty. Lancet 1989; 2: 177-181.
31. Grigg LE et al. Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty. J Am Coll Cardiol 1989; 13: 665-672,
32. Goldman S et al. Improvement in early saphenous vein graft patients after coronary artery bypass surgery with antiplatelet therapy: results of a veterans administration cooperative study. Circulation 1988; 77 (6): 1324-1332.
33. Dehmer GJ et al. Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. N Engl J Med 1988; 319 (12): 733-739.
34. Fleischhauer FJ, Yan WD, Fischell TA. Fish oil improves endothelium dependent coronary vaso-dilation in heart transplant recipients. J Am Coll Cardiol 1993; 21 (4): 982-989.