Autoantibodies that stabilize the molecular interaction of Ku antigen with DNA-dependent protein kinase catalytic subunit

Clinical and Experimental Immunology

Volumn 105, Issue 3, 1996, Pages 460-467

  Satoh, M ^a   Ajmani, A K ^a   Stojanov, L ^a   Langdon, J J ^a   Ogasawara, T ^b   Wang, J ^a   Dooley, M A ^a   Richards, H B ^a   Winfield, J B ^a   Carter, T H ^c   Reeves, W H ^a,d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b KEIO UNIVERSITY   (Japan)

^c ST JOHN'S UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Autoantibodies; DNA dependent protein kinase; DNA PK(cs); Ku antigen

Indexed keywords

AUTOANTIBODY; EPITOPE; KU ANTIGEN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; HUMAN; IMMUNOBLOTTING; MOLECULAR INTERACTION; PRIORITY JOURNAL; RHEUMATIC DISEASE;

EID: 9544220766     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-775.x     Document Type: Article

References (34)

1. Hardin JA. The lupus autoantigens and the pathogenesis of SLE. Arthritis Rheum: 1986; 29:457-60.
2. Mattioli M, Reichlin M. Physical association of two nuclear antigens and mutual occurrence of their antibodies: the relationship of the Sm and RNA protein (Mo) systems in SLE sera. J Immunol 1973; 110:1318-24.
3. Reeves WH, Fisher DE, Lahita RG, Kunkel HG. Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies. J Clin Invest 1985; 75:580-7.
4. Fatenejad S, Mamula MJ, Craft J. Role of intermolecular intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proc Natl Acad Sci USA 1993; 90:12010-4.
5. Lake P, Mitchison NA. Regulatory mechanisms in the immune response to cell-surface antigens. Cold Spring Harbor Symp Quant Biol 1976; 41:589-95.
6. Russell SM, Liew FY. T cells primed by influenza virion internal components can cooperate in antibody response to haemagglutinin. Nature (Lond) 1979; 280:147-8.
7. Scherle PA, Gerhard W. Functional analysis of influenza-specific helper T cell clones in vivo: T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin. J Exp Med 1986; 164:1114-28.
8. Weaver DT. V (D)J recombination and double-strand break repair. Adv Immunol 1995; 58:29-85.
9. Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S, Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies from patients with polymyositis-scleroderma overlap. J Clin Invest 1981; 68:611-20.
10. Reeves WH. Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J Exp Med 1985; 161:18-39.
11. Yaneva M, Arnett FC. Antibodies against Ku protein in sera from patients with autoimmune diseases. Clin Exp Immunol 1989; 76:366-72.
12. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-7.
13. Masi AT, Rodnan GP, Medsger TA, Altman RD, D'Angelo WA, Fries JF. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23:581-90.
14. Arnett FC, Edworthy S, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
15. Bohan A, Peter JB. Polymyositis and dermatomyositis. N Engl J Med 1975; 292:344-7.
16. Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 1987; 84:9150-4.
17. Kotzin BL, Lafferty JA, Portanova JP, Rubin RL, Tan EM. Monoclonal anti-histone autoantibodies derived from murine models of lupus. J Immunol 1984; 133:2554-9.
18. Wang J, Satoh M, Pierani A et al. Assembly and DNA binding of recombinant Ku (p70 p80) autoantigen defined by a novel monoclonal antibody specific for p70 p80 heterodimers. J Cell Sci 1994; 107:3223-33.
19. Carter T, Vancurova I, Sun I, Lou W, DeLeon S. A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol 1990; 10: 6460-71.
20. Satoh M, Wang J, Reeves WH. Role of free p70 (Ku) subunit in posttranslational stabilization of newly synthesized p80 during DNA-dependent protein kinase assembly. Eur J Cell Biol 1995; 66:127-35.
21. Topfer F, Gordon T, McCluskey J. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci USA 1995; 92:875-9.
22. Reeves WH, Pierani A, Chou CH et al. Epitopes of the p70 and p80 (Ku) lupus autoantigens. J Immunol 1991; 146:2678-86.
23. Suwa A, Hirakata M, Takeda Y, Jesch SA, Mimori T, Hardin JA. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci USA 1994; 91:6904-8.
24. Seelig HP, Schranz P, Schroter H, Wiemann C, Griffiths G, Renz M. Molecular genetic analyses of a 376-kilodalton golgi complex membrane protein (Giantin). Mol Cell Biol 1994; 14:2564-76.
25. Casiano CA, Landberg G, Ochs RL, Tan EM. Autoantibodies to a novel cell cycle-regulated protein that accumulates in the nuclear matrix during S phase and is localized in the kinetochores and spindle midzone during mitosis. J Cell Sci 1993; 106:1045-56.
26. Rubin RL, McNally EM, Nusinow SR, Robinson CA, Tan EM. IgG antibodies to the histone complex H2A-H2B characterize procainamide-induced lupus. Clin Immunol Immunopathol 1985; 36:49-59.
27. Burlingame RW, Boey ML, Starkebaum G, Rubin RL. The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J Clin Invest 1994; 94:184-92.
28. Targoff IN, Trieu EP, Miller FW. Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 1993; 91:2556-64.
29. Rouas N, Christophe S, Housseau F, Bellet D, Guillet JG, Bidart JM. Influence of protein-quaternary structure on antigen processing. J Immunol 1993; 150:782-92.
30. Doug X, Hamilton KJ, Satoli M, Wang J, Reeves VH. Initiation of autoimmunily to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J Exp Med 1994; 179:1243-52
31. Theofilopoulos AN. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol Today 1995; 16:90-98.
32. Cibotti R, Kanellopoulos JM, Cabaniols JP et al. Tolerance to a self protein involves its immunodominant but does not involve its subdominant determinants. Proc Natl Acad Sci USA 1992; 89:416-20.
33. Soldevila G, Geiger T, Flavell RA. Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen. J Immunol 1995; 155:5590-600.
34. Casciola-Rosen LA, Anhalt GJ, Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 1995; 182:1625-34.