Possible origin of murine AIDS (MAIDS) virus: Conversion of an endogenous retroviral p12(gag) sequence to a MAIDS-inducing sequence by frameshift mutations

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 6405-6409

  Kubo, Yoshinao ^a   Kakimi, Kazuhiro ^a   Higo, Kyoko ^a   Kobayashi, Hirohiko ^a   Ono, Takeshi ^a   Iwama, Yuko ^a   Kuribayashi, Kagemasa ^a   Hiai, Hiroshi ^b   Adachi, Akio ^a   Ishimoto, Akinori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE LOCATION; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS GENE;

EID: 9444299117     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.6405-6409.1996     Document Type: Article

References (24)

1. Aziz, D. C., Z. Hanna, and P. Jolicoeur. 1989. Severe immunodeficiency disease induced by a defective murine leukaemia virus. Nature (London) 338:505-508.
2. Buller, R. M. L., R. A. Yetter, T. N. Fredrickson, and H. C. Morse III. 1987. Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia virus. J. Virol. 61:383-387.
3. Casabianca, A., and M. Magnani. 1994. A p12 gag gene homologue is present in the mouse genome. Biochem. Mol. Biol. Int. 32:691-696.
4. Chattopadhyay, S. K., H. C. Morse III, M. Makino, S. K. Ruscetti, and J. W. Hartley. 1989. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc. Natl. Acad. Sci. USA 86: 3862-3866.
5. Chattopadhyay, S. K., D. N. Sengupta, T. N. Fredrickson, H. C. Morse III, and J. W. Hartley. 1991. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice. J. Virol. 65:4232-4241.
6. Cheung, S. C., S. K. Chattopadhyay, H. C. Morse III, and P. M. Pitha. 1991. Expression of defective virus and cytokine genes in murine AIDS. J. Virol. 65:823-828.
7. Cho, B. C., J. D. Shaughnessy, Jr., D. A. Largaespada, H. G. Bedigian, A. M. Buchberg, N. A. Jenkins, and N. G. Copeland. 1995. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. J. Virol. 69:7138-7146.
8. Coffin, J. M. 1992. Genetic diversity and evolution of retroviruses. Curr. Top. Microbiol. Immunol. 176:143-164.
9. Deng, W. P., and J. A. Nickoloff. 1992. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal. Biochem. 200:81-86.
10. Gayama, S., B. A. Vaupel, and O. Kanagawa. 1995. Sequence heterogeneity of murine acquired immunodeficiency syndrome: the role of endogenous virus. Int. Immunol. 7:861-868.
11. Hartley, J. W., T. N. Fredrickson, R. A. Yetter, M. Makino, and H. C. Morse III. 1989. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J. Virol. 63:1223-1231.
12. Jolicoeur, P. 1991. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J. 5:2398-2405.
13. Kanagawa, O., B. A. Vaupel, S. J. Korsmeyer, and J. H. Russell. 1995. Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction. Eur. J. Immunol. 25:2421-2427.
14. gag regions are both necessary for the pathogenicity of the murine AIDS virus. J. Virol. 58:5532-5537.
15. Kubo, Y., Y. Nakagawa, K. Kakimi, H. Matsui, K. Higo, L. Wang, H. Kobayashi, T, Hirama, and A. Ishimoto. 1994. Molecular cloning and characterization of a murine AIDS virus-related endogenous transcript expressed in C57BL/6 mice. J. Gen. Virol. 75:881-888.
16. Kubo, Y., Y. Nakagawa, K. Kakimi, H. Matsui, M. Iwashiro, K. Kuribayashi, T. Masuda, H. Hiai, T. Hirama, S.-I. Yanagawa, and A. Ishimoto. 1992. Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus. J. Virol. 66:5691-5695.
17. Kunkel, T. A. 1985. The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA. Proc. Natl. Acad. Sci. USA 82:488-492.
18. Latarjet, R., and J.-F. Duplan. 1962. Experiment and discussion on leukemogenesis by cell-free extracts of radiation-induced leukemia in mice. Int. J. Radiat. Biol. 5:339-344.
19. Markowitz, D., S. Goff, and A. Bank. 1988. Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400-406.
20. Morse, H. C., III, S. K. Chatlopadhyay, M. Makino, T. N. Fredrickson, A. W. Hugin, and J. W. Hartley. 1992. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 6:607-621.
21. Mosier, D. E., R. A. Yetter, and H. C. Morse III. 1985. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J. Exp. Med. 161:766-784.
22. Nakagawa, Y., K. Kakimi, W. Ling, Y. Kubo, K. Higo, T. Masuda, K. Kuribayashi, M. Iwashiro, Y. Komatz, T. Hirama, A. Adachi, and A. Ishimoto. 1994. Inhibition of murine AIDS (MAIDS) development by the transplantation of bone marrow cells carrying the Fv-4 resistance gene to MAIDS virus-infected mice. J. Virol. 68:1438-1441.
23. Portnoi, D., A. M. Stall, D. Schwartz, T. C. Merigan, L. A. Herzenberg, and T. Basham. 1990. Zidovudine inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. J. Immunol. 144: 1705-1710.
24. Pozsgay, J. M., M. W. Beilharz, B. D. Wines, A. D. Hess, and P. M. Pitha. 1993. The MA (p15) and p12 regions of the gag gene arc sufficient for the pathogenicity of the murine AIDS virus. J. Virol. 67:5989-5999.