Novel sesterterpenes from Leucosceptrum canum of nepalese origin

Organic Letters

Volumn 6, Issue 23, 2004, Pages 4139-4142

  Choudhary, Muhammad Iqbal ^a   Ranjit, Rosa ^a   Atta ur Rahman, ^a   Hussain, Sajjad ^a   Devkota, Krishna Prasad ^a   Shrestha, Tirtha Maiya ^b   Parvez, Masood ^c  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b Ministry of Forest and Soil Conservation   (Nepal)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCOSCEPTRUM CANUM EXTRACT; PLANT EXTRACT; PROLYL ENDOPEPTIDASE; SESTERTERPENE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; ENZYME ACTIVITY; LEUCOSCEPTRUM CANUM; MEDICINAL PLANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY DIFFRACTION;

EID: 9444274814     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol040040y     Document Type: Article

References (15)

1. Hooker, J. D. Flora of British India; Bishen Singh Mahendra Pal Singh Publishers: Dehradun, 1983; Vol. IV, p 699.
2. Flora of Kathmandu Valley. In Bull. Department Med. Plant, Nepal, No. 11; His Majesty's Government of Nepal, Ministry of Forests and Soil Conservation, Department of Medicinal Plants: Kathmandu, Nepal, 1986; p 561.
3. Choudhary, M. I.; Ranjit, R.; Atta-ur-Rahman; Shrestha, T. M.; Yasin, A.; Parvez, M. J. Org. Chem. 2004, 69, 2906.
4. Plant Material. The aerial parts of L. canum Sm. were collected from Godawari, Kathmandu, Nepal on November 26, 2000, at an altitude of 1550 m. The plant was identified by senior scientific officer, Mrs. Tirth Maiya Shrestha, and a voucher specimen (T037) was deposited at The National Herbarium and Research Laboratory, Department of Plant Resources, Ministry of Forests and Soil Conservation, Godawari, Kathmandu, Nepal.
5. Extraction and Isolation. Aerial parts of L. canum were cut into small pieces and dried in the shade. The air-dried and powdered plant material (1.75 kg) was soaked in hexane (10 L) at room temperature for 2 days, filtered and evaporated under reduced pressure. This process was repeated three times to yield 34.03 g of hexane extract. The plant material was subsequently soaked in dichloromethane, ethyl acetate, and methanol. The resulting organic extracts were filtered and concentrated under reduced
6. Pavia, D. L.; Lampman, G. M.; Kriz, G. S. Introduction to Spectroscopy, 2nd ed.; Harcourt Brace College Publishers: Fort Worth, TX. 1996.
7. Atta-ur-Rahman; Choudhary, M. I. Solving Problems by NMR Spectroscopy; Academic Press: San Diego, 1996.
8. 7, m/z 430.1924), EI MS m/z (rel intensity %) 430 (33), 319 (10), 292 (25), 249 (60), 234 (50), 203 (35), 139 (50), 111 (46), 110 (73), 83 (100).
9. 2 = 0.087.
10. 2 = 0.087.
11. 2 = 0.087.
12. 6, m/z 432.2444), EI MS m/z (rel intensity %) 432 (7), 349 (22), 320 (10), 292 (15), 251 (4), 233 (5), 196 (9), 181 (15), 153 (39), 112 (17), 109 (20), 97 (30), 83 (100).
13. Kobayashi, W.; Miyase, T.; Sano, M.; Umehara, K.; Warashina, T.; Noguchi, H. Biol. Pharm. Bull. 2002, 25, 1049.
14. 50 = 129.26 ± 3.28 μM: Fan, W.; Tezuka, Y.; Ni, K. M.; Kadota, S. Chem. Pharm. Bull. 2001, 49, 396).
15. 50 = 129.26 ± 3.28 μM: Fan, W.; Tezuka, Y.; Ni, K. M.; Kadota, S. Chem. Pharm. Bull. 2001, 49, 396).