Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: An epigenetic mechanism of tumour progression?

International Journal of Cancer

Volumn 67, Issue 4, 1996, Pages 563-572

  Bond, Jane A ^a   Oddweig Ness, Gro ^a,c   Rowson, Janet ^a   Ivan, Mircea ^a   White, Denise ^b   Wynford Thomas, David ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; EXPRESSION VECTOR; GENE TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIMIAN VIRUS 40; THYROID CANCER; THYROID FOLLICLE CELL;

ANTIGENS, VIRAL, TUMOR; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CLONE CELLS; EPITHELIAL CELLS; HUMANS; ONCOGENES; SIMIAN VIRUS 40; THYROID GLAND; THYROID NEOPLASMS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 9444263685     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960807)67:4<563::AID-IJC16>3.0.CO;2-8     Document Type: Article

References (26)

1. BIRCHMEIER, W. and BEHRENS, J., Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. biophys. Acta, 1198, 11-26 (1994).
2. BOND, J.A., DAWSON, T., LEMOINE, N.R. and WYNFORD-THOMAS, D., Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras. Mol. Carcinogenesis, 5, 129-135 (1992).
3. BOND, J.A., WYLLIE, F.S., IVAN, M., DAWSON, T. and WYNFORD-THOMAS, D., A variant epithelial subpopulation in normal thyroid with high proliferative capacity in vitro. Mol. cell. Endocrinol., 93, 175-183 (1993).
4. BOND, J.A., WYLLIE, F.S., ROWSON, J., RADULESCU, A. and WYNFORD-THOMAS, D., In vitro reconstruction of tumour initiation in a human epithelium. Oncogens, 9, 281-290 (1994).
5. BRABANT, G., HOANG-VU, C., CETIN, Y., DRALLE, H., SCHEUMANN, G., MOLNE, J., HANSSON, G., JANSSON, S., ERICSON, L.E., and NILSSON, M., E-cadherin: a differentiation marker in thyroid malignancies. Cancer Res., 53, 4987-4993 (1993).
6. CARCANGIU, M.L., STEEPER, T., ZAMPI, G. and ROSAI, J., Anaplastic thyroid carcinoma. Amer. J. clin. Pathol., 83, 135-158 (1985).
7. DANOS, O., and MULLIGAN, R.C., Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc. nat. Acad. Sci. (Wash.), 85, 6460-6464 (1988).
8. DUMONT, J.E., LAMY, F., ROGER, P. and MAENHAUT, C., Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotrophin and other factors. Phys. Rev., 72, 667-697 (1992).
9. FABBRO, D., DI LORETO, C., BELTRAMI, C.A., BELFIORE, A., DI LAURO, R. and DAMANTE, G., Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms. Cancer Res., 54, 4744-4749 (1994).
10. HELDIN, N-E., CVEJIC, D., SMEDS, S. and WESTERMARK, B., Coexpression of functionally active receptors for thyrotropin and platelet-derived growth factors in human thyroid carcinoma cells. Endocrinology, 129, 2187-2193 (1991).
11. JAT, P.S. and SHARP, P.A., Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts. J. Virol., 59, 746-750 (1986).
12. KIM, N.W., PIATYSZEK, M.A., PROWSE, K.R., HARLEY, C.B., WEST, M.D., HO, P.L.C., COVIELLO, G.M., WRIGHT, W.E., WEINRICH, S.L. and SHAY, J.W., Specific associations of human telomerase activity with immortal cells and cancer. Science, 266, 2011-2015 (1994).
13. LANE, E.B., Monoclonal antibodies provide specific intramolecular markers for the study of epithelial tonofilament organisation. J. Cell Biol., 92, 665-673 (1982).
14. LEDENT, C., DUMONT, J., VASSART, G. and PARMENTIER, M., Thyroid adenocarcinomas secondary to tissue-specific expression of simian virus-40 large T-antigen in transgenic mice. Endocrinology, 129, 1391-1401 (1991).
15. LEMOINE N.R., MAYALL, E.S., JONES, T., SHEER, D., MCDERMID, S., KENDALL-TAYLOR, P. and WYNFORD-THOMAS, D., Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection. Brit. J. Cancer, 60, 897-903 (1989).
16. LOEB, L.A., Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 51, 3075-3079 (1991).
17. NAVARRO, P., GOMEZ, M., PIZARRO, A., GAMALLO, C., QUINTANILLA, M. and CANO, A., A role for the E-cadherin cell-cell adhesion molecule during tumour progression of mouse epidermal carcinogenesis. J. Cell. Biol, 115, 517-533 (1991).
18. ROGAN, E.M., BRYAN, T.M., HUKKU, B., MACLEAN, K., CHANG, A. C-M., MOY, E.L., ENGLEZOU, A., WARNEFORD, S.G., DALLA-POZZA, L. and REDDEL, R.R., Alterations in p53 and p16ink4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. cell. Biol., 15, 4745-4753 (1995).
19. STAMPS, A.C., DAVIES, S.C., BURMAN, J. and O'HARE, M.J., Analysis of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct. Int. J. Cancer, 57, 865-874 (1994).
20. STAMPS, A.C., GUSTERSON, B.A. and O'HARE, M.J., Are tumours immortal? Europ. J. Cancer, 28A, 1495-1500 (1992).
21. WAZER, D.E., LIU, X-L, CHU, Q., GAO, Q. and BAND, V., Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc. nat. Acad. Sci. (Wash.), 92, 3687-3691 (1995).
22. WILLIAMS, D.W., WILLIAMS, E.D. and WYNFORD-THOMAS, D., Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells. Brit. J. Cancer, 57, 535-539 (1988).
23. WILLIAMS, D.W. and WILLIAMS, E.D., The pathology of follicular thyroid epithelial tumours. In: D. Wynford-Thomas and E.D. Williams (ed). Thyroid tumours: molecular basis of pathogenesis, pp. 57-65, Churchill Livingstone, Edinburgh (1989).
24. WRIGHT, W.E., PEREIRA-SMITH, O.M. and SHAY, J.W., Reversible cellular senescence: implications for immortalisation of normal human diploid fibroblasts. Mol. cell. Biol., 9, 3088-3092 (1989).
25. WYNFORD-THOMAS, D., In vitro models of thyroid cancer. Cancer Surv., 16, 115-133 (1993).
26. WYNFORD-THOMAS, D., BOND, J.A., WYLLIE, F.S., BURNS, J.S., WILLIAMS, E.D., JONES, T., SHEER, D. and LEMOINE, N.R., Conditional immortalisation of human thyroid epithelial cells: a tool for analysis of oncogene action. Mol. cell. Biol., 10, 5365-5377 (1990).