Ceftriaxone in amyotrophic lateral sclerosis

European Journal of Neurology

Volumn 3, Issue 4, 1996, Pages 295-298

  Beghi, E ^a,b,c   Presti, Maria Laura ^a   Manzoni, Cristina ^a   Mennini, Tiziana ^a   Cavestro, Cinzia ^a   Poloni, Marco ^d   Micheli, Anna ^d   Pinelli, Paolo ^d   Mai, Roberto ^e   Facchetti, Dante ^e   Testa, Daniela ^f   Cornelio, Ferdinando ^f   Mazzini, Letizia ^g   Baizarini, Carla ^g   Mora, Gabriele ^g   Chiò, Adriano ^h   Schiffer, Davide ^h   Tonali, Pietro ⁱ   Sabatelli, Mario ⁱ   Mignogna, Teresa ⁱ   Lippi, Giovanna ⁱ   Manfredi, Mario ^j   Inghilleri, Maurizio ^j   Musicco, Massimo ^k   more..

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e Centro Medico di Gussago   (Italy)

^f DEPARTMENT OF NEUROSURGERY   (Italy)

^g Centro Medico di Veruno   (Italy)

^h UNIVERSITY OF TURIN   (Italy)

ⁱ CATHOLIC UNIVERSITY   (Italy)

^j SAPIENZA UNIVERSITY OF ROME   (Italy)

^k CNR   (Italy)

more..

Author keywords

Amyotrophic lateral sclerosis; Ceftriaxone; Glutamate uptake; Spinal cord synaptosomes

Indexed keywords

CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; GLUTAMIC ACID; NEUROTRANSMITTER;

ABDOMINAL PAIN; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ATOPY; CLINICAL TRIAL; DIARRHEA; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE RIGIDITY; NAUSEA; NEUROCHEMISTRY; NEUROMUSCULAR SYNAPSE; PRIORITY JOURNAL; SPINAL CORD; SYNAPSE; SYNAPTOSOME;

EID: 9444234431     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-1331.1996.tb00220.x     Document Type: Article

References (13)

1. Battaglioli G, Martin DL, Plummer J and Messer A (1993) Synaptosomal glutamate uptake declines progressively in the spinal cord of a mutant mouse with motor neuron disease. Journal of Neurochemistry, 60, 1567-1569.
2. Carod-Artal FJ, Perez-Lopez-Fraile I, Gracia-Naya M and Giron Mombiela J (1994) Failure of empirical treatment with ceftriaxone in motor neuron disease. Neurologia, 9, 29-31.
3. Italian ALS Study Group (1993) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? Neurology, 43, 2466-2470.
4. Medical Research Council (1943) Aids to the investigation of peripheral nerve injuries. In: War Memorandum, 2nd edn revised, pp. 11-46. London, HMSO.
5. Mennini T, Bernasconi P and Fiori M (1993) Neurotoxicity of nonionic low-osmolar contrast media. A receptor binding study. Investigative Radiology, 28, 821-827.
6. Norris FH, Calanchini PR, Fallat RJ, Panchari S and Jewett B (1974) The administration of guanidine in amyotrophic lateral sclerosis. Neurology, 24, 721-728.
7. Plaitakis A, Constantakakis E and Smith J (1990) The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis. Annals of Neurology, 28, 3-8.
8. Richard DM, Hell RC, Brodgen RN, Speight TM and Avery GS (1984) Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs, 27, 469-527.
9. Robberecht W (1992) Lack of improvement with ceftriaxone in motoneuron disease (letter). Lancet, 340, 1096-1097.
10. Rothstein JD and Kuncl RW (1995) Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. Journal of Neurochemistry, 65, 643-651.
11. Rothstein JD, Martin LJ and Kuncl RW (1992) Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. New England Journal of Medicine, 326, 1464-1468.
12. Smith LG (1992a) Improvement of patients with amyotrophic lateral sclerosis given ceftriaxone (letter). Lancet, 339, 1417.
13. Smith LG (1992b) Failure of ceftriaxone for amyotrophic lateral sclerosis (letter). Lancet, 340, 379.