Cellular basis of the GnRH pulse generator

Acta Obstetrica et Gynaecologica Japonica

Volumn 48, Issue 8, 1996, Pages 573-577

  Weiner, Richard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN;

ANIMAL CELL; CELL COMMUNICATION; CONFERENCE PAPER; GONADORELIN RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MOUSE; NEUROSECRETORY CELL; NONHUMAN; PHENOTYPE; PULSATILE HORMONE RELEASE;

ANIMALS; BIOLOGICAL CLOCKS; CALCIUM; CELL COMMUNICATION; CELL LINE; GONADOTROPIN-RELEASING HORMONE; HUMANS; NEURONS; NEUROSECRETION;

EID: 9444232270     PISSN: 03009165     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (22)

1. Mellon P, Windle J, Goldsmith P, Padula C, Roberts J, Weiner R. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 1990 ; 5 : 1-10
2. Liposits Z, Merchenthaler I, Wetsel WC, Reid JJ, Mellon PL, Weiner RI, Negro-Vilar A. Morphological characterization of immortalized hypothalamic neurons (GT1 7) synthesizing luteinizing hormone-releasing hormone. Endocrinology 1991 ; 129 : 1575-1583
3. Wetsel WC, Mellon PL, Weiner RI, Negro-Vilar A. Metabolism of pro-LHRH in immortalized hypothalamic neurons. Endocrinology 1991 ; 129 : 1584-1595
4. Martinez de la Escalera G, Choi A, Weiner R. Generation and synchronization of gonadotropin-releasing hormone pulses: Intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 1992 ; 89 : 1852-1855
5. Wetsel W, Valenca M, Merchanthaler I, Liposits Z, Lopez F, Weiner R, Mellon P, Negro-Vilar A. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci USA 1992 ; 89 : 4149-4153
6. Krsmanovic L, Stojikovic S, Merelli F, Dufour S, Virmani M, Catt K. Calcium signaling and episodic secretion of gonadotropin-releasing hormone in hypothalamic neurons. Proc Natl Acad Sci USA 1992 ; 89 : 8462-8466
7. Masotto C, Negro-Vilar A. Gonadectomy influences the inhibitory effect of the endogenous opiate system on pulsatile gonadotropin secretion. Endocrinology 1988 ; 123 : 747-752
8. Steiner RA, Bremner WJ, Clifton DK. Regulation of luteinizing hormone pulse frequency and amplitude by testosterone in the adult male rat. Endocrinology 1982 ; 111 : 2055-2061
9. Bosma MM. Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing hormone (GnRH) neurons. J Membrane Biol 1993 ; 136 : 85-96
10. Hales T, Sanderson M, Charles A. GABA has excitatory actions on GnRH secreting immortalized hypothalamic (GT1-7) neurons. Neuroendocrinology 1994 ; 59 : 297-308
11. Krsmanovic L, Stojikovic S, Mertz L, Tomic M, Catt M. Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc Natl Acad Sci USA 1993 ; 90 : 3908-3912
12. Charles AC, Hales TG. Mechanisms of spontaneous calcium oscillations and action potentials immortalized hypothalamic (GT1-7) neurons. J Neurophysiol 1995 ; 73 : 56-64
13. Kusano K, Fueshko H, Wray S. Electrical and synaptic properties of embryonic luteinizing hormone-releasing hormone neurons in explant culture. Proc Natl Acad Sci USA 1995 ; 92 : 3918-3922
14. Leranth C, Segura L, Palkovits M, Maclusky N, Shanabrough M, Naftolin F. The LH-RH-containing neuronal network in the preoptic area of the rat: demonstration of LH-RH-containing nerve terminals in synaptic contact with LH-RH neurons. Brain Res 1985 ; 345 : 332-336
15. Matesic D, Germak J, Dupont E, Madhukar B. Immortalized luteinizing hormone-releasing hormone neurons express a connexin 26-like protein and display functional gap junction coupling assayed by fluorescence recovery after photobleaching. Neuroendocrinology 1993 ; 58 : 485-492
16. Martinez de la Escalera G, Choi A, Weiner R. β-Adrenergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via receptors positively coupled to adenylate cyclase. Endocrinology 1992 ; 131 : 1397-1402
17. Martinez de la Escalera G, Gallo F, Choi A, Weiner R. Dopaminergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase. Endocrinology 1992 ; 131 : 2965-2971
18. Martinez de la Escalera G, Choi A, Weiner R. Signaling pathways involved in GnRH secretion in GT1 cells. Neuroendocrinology 1994 ; 61 : 310-317
19. Gerisch G. Cyclic AMP and other signals controlling cell development and differentiation in Dictyostelium. Ann Rev Biochem 1987 ; 56 : 853-879
20. Booker G. Oscillations of cyclic adenosine monophosphate concentration during myocardial contraction cycle. Science 1973 ; 182 : 933-934
21. Sakakibara H, Conti M, Weiner R. Role of cyclic nucleotide phosphodiesterases in the regulation of gonadotropin releasing hormone (GnRH) secretion from GT1 GnRH neuronal cell lines. Program 10th Internat Cong of Endocrinology 1996 ; 230
22. Vitalis V, Weiner RI. Inhibition of protein kinase A (PKA) stimulates GnRH release in GT1 cells and does not block cAMP induced stimulation of GnRH. Society for Neuroscience Abstracts 1996 ; 22 (in press)