Distinctive prepubertal vulval fibroma - A hitherto unrecognized mesenchymal tumor of prepubertal girls: Analysis of 11 cases

American Journal of Surgical Pathology

Volumn 28, Issue 12, 2004, Pages 1601-1608

  Iwasa, Yoko ^a,b   Fletcher, Christopher D M ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Fibroma; Prepubertal; Soft tissue; Stromal tumor; Vulva

Indexed keywords

ALPHA ACTIN; CD34 ANTIGEN; DESMIN; PROTEIN S 100;

ADIPOSE TISSUE; ARTICLE; CANCER SURGERY; CHILD; CYST; FEMALE; FIBROMA; FOLLOW UP; HEMANGIOMA; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; LIPOMA; LYMPHANGIOMA; LYMPHEDEMA; MESENCHYMOMA; MICROSCOPY; MITOSIS RATE; NERVOUS TISSUE; PREOPERATIVE EVALUATION; PREPUBERTAL VULVAL FIBROMA; PREPUBERTY; SMOOTH MUSCLE; SPINDLE CELL; STROMA; SUBCUTANEOUS TISSUE; SUBMUCOSA; TUMOR CELL; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR VOLUME; VASCULAR TISSUE; VULVA TUMOR;

CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; FIBROMA; HUMANS; IMMUNOHISTOCHEMISTRY; VULVAR NEOPLASMS;

EID: 9444225918     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200412000-00008     Document Type: Article

References (35)

1. Allen PW, Dymock RB, MacCormac LB. Superficial angiomyxomas with and without epithelial components: report of 30 tumors in 28 patients. Am J Surg Pathol. 1988;12:519-530.
2. Al-Nafussi AI, Rebello G, Hughes D, et al. Benign vaginal polyp: a histological, histochemical and immunohistochemical study of 20 polyps with comparison to normal vaginal subepithelial layer. Histopathology. 1992;20:145-150.
3. Calonje E, Guerin D, McCormick D, et al. Superficial angiomyxoma: clinicopathologic analysis of a series of distinctive but poorly recognized cutaneous tumors with tendency for recurrence. Am J Surg Pathol. 1999;23:910-917.
4. Clatch RJ, Drake WK, Gonzalez JG. Aggressive angiomyxoma in men: a report of two cases associated with inguinal hernias. Arch Pathol Lab Med. 1993;117:911-913.
5. Elliott GB, Elliott JDA. Superficial stromal reactions of lower genital tract. Arch Pathol. 1973;95:100-101.
6. Falkner F, Tanner JM. eds. Human Growth: A Comprehensive Treatise, 2nd ed, vol. 2. New York: Plenum Press, 1986:186-195.
7. Fetsch JF, Laskin WB, Lefkowitz M, et al. Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer. 1996;78:79-90.
8. Fetsch JF, Laskin WB, Tavassoli FA. Superficial angiomyxoma (cutaneous myxoma): a clinicopathologic study of 17 cases arising in the genital region. Int J Gynecol Pathol. 1997;16:325-334.
9. Fletcher CDM, ed. Diagnostic Histopathology of Tumors: Peripheral Neuroectodermal Tumors, 2nd ed. London: Churchill Livingstone, 2000:1686-1689.
10. Fletcher CDM, Tsang WYW, Fisher C, et al. Angiomyofibroblastoma of the vulva: a benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol. 1992;16:373-382.
11. Granter SR, Nucci MR, Fletcher CDM. Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology. 1997;30:3-10.
12. Hartmann C-A, Sperling M, Stein H. So-called fibroepithelial polyps of the vagina exhibiting an unusual but uniform antigen profile characterized by expression of desmin and steroid hormone receptors but no muscle-specific actin or macrophage markers. Am J Clin Pathol. 1990;93:604-608.
13. Iezzoni JC, Fechner RE, Wong LS, et al. Aggressive angiomyxoma in males: a report of four cases. Am J Clin Pathol. 1995;104:391-396.
14. Imai A, Furui T, Tamaya T. Gynecologic tumors and symptoms in childhood and adolescence: 10-years' experience. Int J Gynecol Obstet. 1994;45:227-234.
15. Iwasa Y, Fletcher CDM. Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. Am J Surg Pathol. 2004;28:1426-1435.
16. Kazmierczak B, Wanschura S, Meyer-Bolte K, et al. Cytogenetic and molecular analysis of an aggressive angiomyxoma. Am J Pathol. 1995;147:580-585.
17. Kurman RJ. eds. Blaustein's Pathology of the Female Genital Tract, 5th ed. New York: Springer, 2002:38-39.
18. Kurman RJ, Norris HJ, Wilkinson E. Atlas of Tumor Pathology: Tumors of the Cervix, Vagina, and Vulva, 3rd ed. Washington, DC: Armed Forces Institute of Pathology, 1990:1-17.
19. Laskin WB, Fetsch JF, Mostofi FK. Angiomyofibroblastoma like tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1998;22:6-16.
20. Laskin WB, Fetsch JF, Tavassoli FA. Angiomyofibroblastoma of the female genital tract: analysis of 17 cases including a lipomatous variant. Hum Pathol. 1997;28:1046-1055.
21. Mucitelli DR, Charles EZ, Kraus FT. Vulvovaginal polyps: histologic appearance, ultrastructure, immunocytochemical characteristics, and clinicopathologic correlations. Int J Gynecol Pathol. 1990;9:20-40.
22. Nasu K, Fujisawa K, Takai N, et al. Angiomyofibroblastoma of the vulva. Int J Gynecol Cancer. 2002;12:228-231.
23. Newton WA Jr, Gehan EA, Webber BL, et al. Classification of rhabdomyosarcomas and related sarcomas: pathologic aspects and proposal for a new classification. An intergroup rhabdomyosarcoma study. Cancer. 1995;76:1073-1085.
24. Newton WA Jr, Soule EH, Hamoudi AB, et al. Histopathology of childhood sarcomas, intergroup rhabdomyosarcoma studies I and II: clinicopathologic correlation. J Clin Oncol. 1988;6:67-75.
25. Norris HJ, Taylor HB. Polyps of the vagina: a benign lesion resembling sarcoma botryoides. Cancer. 1966;19:227-232.
26. Nucci MR, Fletcher CDM. Vulvovaginal soft tissue tumours: update and review. Histopathology. 2000;36:97-108.
27. Nucci MR, Granter SR, Fletcher CDM. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1997;21:636-644.
28. Nucci MR, Young RH, Fletcher CDM. Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma. Am J Surg Pathol. 2000;24:231-240.
29. Ramani O, Bradley NJ, Fletcher CDM. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology. 1990;17:237-242.
30. Schmitt-Graff A, Desmoaliere A, Gabbiani G. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch. 1994;425:3-24.
31. Skalova A, Michal M, Husek K, et al. Aggressive angiomyxoma of the pelvioperineal region: immunohistological and ultrastructural study of seven cases. Am J Dermatopathol. 1993;15:446-451.
32. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum: report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol. 1983;7:463-475.
33. Tsang WYW, Chan JKC, Lee KC, et al. Aggressive angiomyxoma: a report of four cases occurring in men. Am J Surg Pathol. 1992;16:1059-1065.
34. Van Der Griend MD, Burda P, Ferrier AJ. Angiomyofibroblastoma of the vulva. Gynecol Oncol. 1994;54:389-392.
35. White J, Chan Y-F. Aggressive angiomyxoma of the vulva in an 11-year-old girl. Pediatr Pathol. 1994;14:27-37.