Human erythrocytes bearing electroinserted CD4 neutralize infection in vitro by primary isolates of human immunodeficiency virus type 1

Blood

Volumn 87, Issue 11, 1996, Pages 4839-4844

  Tosi, Pierre Francois ^c   Schwartz, David ^b   Sharma, Usha ^c   Mouneimne, Youssef ^c   Hannig, Jurgen ^c   Li, Gongrong ^c   McKinley, George ^c   Grieco, Michael ^c   Flexner, Charles W ^c   Lazarte, Jaime ^c   Norse, David ^c   Nicolau, Claude ^c   Volsky, David J ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ARTICLE; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; MEMBRANE VESICLE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS CELL INTERACTION; VIRUS ISOLATION; VIRUS NEUTRALIZATION; VIRUS TRANSMISSION;

EID: 9344269939     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.11.4839.bloodjournal87114839     Document Type: Article

References (30)

1. Klatzmann D, Barre-Sinoussi F, Nugeyre M, Dauguet C, Vilmer E, Griselli C, Brun-Vezinet F, Rouzioux C, Gluckman J-C, Chermann J-C, Montagnier L: Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science 225:59, 1984
2. McDougal JS, Mawle A, Cort S, Nicholson J, Cross A, Schlepper-Campbell J, Hicks D, Sligh J: Cellular tropism of the human retrovirus HTLV-III/LAV. J Immunol 135:3151, 1985
3. Smith D, Byrn R, Marsters S, Gregory T, Groopman J, Capon D: Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen. Science 328:1704, 1987
4. Berger E, Fuerst T, Moss B: A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus. Proc Natl Acad Sci USA 85:2357, 1988
5. Deen K, McDougal JS, Inacker R, Folena-Wasserman G, Arthos J, Rosenberg J, Maddon P, Axel R, Sweet R: A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature 331:82, 1988
6. Fisher R, Bertonis J, Meier W, Johnson V, Costopoulos D, Liu T, Tizard R, Walker B, Hirsch M, Schooley R, Flavell R: HIV infection is blocked in vitro by recombinant soluble CD4. Nature 331:76, 1988
7. Hussey R, Rchardson N, Kowalski M, Brown N, Chang H-C, Siliciano R, Dorfman T, Walker B, Sodroski J, Reinherz E: Designing immunoadhesions for AIDS therapy. Nature 331:78, 1988
8. Traunecker A, Luke W, Karalainen K: Soluble CD4 molecules neutralize human immunodeficiency virus type 1. Nature 331:84, 1988
9. Till M, Ghetie V, Gregory T, Patzer E, Porter J, Uhr J, Capon D, Vitetta E: HIV-infected cells are killed by CD4-ricin A chain. Science 242:267, 1988
10. Watanabe M, Reimann K, DeLong P, Liu T, Fisher R, Letvin N: Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques. Nature 337:267, 1989
11. Capon D, Chamow S, Mordenti J, Marsters S, Gregory T, Mitsuya H, Byrn R, Lucas C, Wurm F, Groopman J, Broder S, Smith D: Designing immunoadhesins for AIDS therapy. Nature 337:525, 1989
12. Daar E, Li X, Mougdil T, Ho D: High concentrations of recombinant soluble CD4 are required to neutralize primary HIV-1 isolates. Proc Natl Acad Sci USA 87:6574, 1990
13. Orloff S, Kennedy MS, Belperron A, Maddon P, McDougal JS: Two mechanisms of soluble CD4 mediated inhibition of human immunodeficiency virus type 1 infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4. J Virol 67:1461, 1993
14. Schooley R, Merigan T, Gaut P, Hirsch M, Holodhiy M, Flynn T, Liu S, Byington B, Henochowicz S, Gubish E, Spiggs D, Kufe D, Schindler J, Dawson A, Thomas D, Hanson D, Letwin B, Liu T, Gulinello J, Kennedy S, Fisher R, Ho D: Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Ann Intern Med 112:247, 1990
15. Kahn J, Allan J, Hodges T, Kaplan L, Am C, Fitch H, Izu A, Mordenti Serwin S, Groopman J, Volberding P: The safety and pharmacokinetics of recombinant soluble CD4 (rCD4) in subjects with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex A: Phase I study. Ann Intern Med 112:254, 1990
16. Mouneimne Y, Tosi P-F, Barhoumi R, Nicolau C: Electroinsertion of full length recombinant CD4 into red blood cell membrane. Biochim Biophys Acta 1027:53, 1990
17. Webb N, Madoulet C, Tosi P-F, Broussard D, Sneed L, Nicolau C, Summers M: Cell-surface expression and purification of human CD4 produced in baculovirus-infected insect cells. Proc Natl Acad Sci USA 86:7731, 1989
18. Hannig J, Dawkins C, Tosi P-F, Nicolau C: Stability and immunological reactivity of recombinant membrane CD4 electroinserted into the plasma membrane of erythrocytes. FEBS Lett 359:9, 1995
19. Zeira M, Tosi P-F, Mouneimne Y, Lazarte J, Sneed L, Volsky DJ, Nicolau C: Full-length CD4 electroinserted in the erythrocyte membranes as a long-lived inhibitor of infection by human immunodeficiency virus. Proc Natl Acad Sci USA 88:4409, 1991
20. Hollinger, B F, Mouneimne Y, Lahart C, Tosi P-F, Dimitrov D, Nicolau C: Life span of circulating membrane CD4 inserted into the plasma membrane of autologous Red Blood Cells of HIV-infected subjects. J Acquir Immune Defic Syndr 9:126, 1995
21. + plasma membrane vesicles with HIV-1 and HIV-1 envelope glycoprotein-expressing cells. J Acquir Immune Defic Syndr 5:915 1992
22. Casareale D, Stevenson M, Sakai K, Volsky DJ: A human T-cell line resistant to cytopathic effect of the human immunodeficiency virus. Virology 156:40, 1987
23. Potash, MJ, Huang X-B, Tosi P-F, Mouneimne Y, Nicolau C, Volsky DJ: HIV-1 reverse transcription is triggered by virus-cell membrane fusion. IXth International Conference on AIDS, Berlin, Germany, Abstract WS A03-2, 1993
24. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R: The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333, 1986
25. Chesebro B, Buller R, Portis J, Wehrly K: Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells. J Virol 64:215, 1990
26. Clapham PR, Blanc D, Weiss RA: Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus type 1 and 2 and by simian immunodeficiency virus. Virology 181:703, 1991
27. Volsky B, Sakai K, Reddy MM, Volsky DJ: A system for the high efficiency replication of HIV-1 inneural cells and its application to anti-viral evaluation. Virology 186:303, 1992
28. Dragic T, Picard L, Alizon M: Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 envelope glycoproteins. J Virol 69:10131, 1995
29. Pantaleo G, Graziosi C, Demarest J, Butini L, Montroni M, Fox C, Orenstein J, Kotler D, Fauci A: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355, 1993
30. Embretson J, Zupancic M, Ribas J, Burke A, Racz P, Tenner-Racz K, Haase A: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359, 1993