Sequence-independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate oligodeoxynucleotides

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 443-450

  Wang, Weizheng ^a   Chen, Hong Jun ^a   Schwartz, Allan ^a   Cannon, Paul J ^a   Stein, C A ^a   Rabbani, LeRoy E ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

basic fibroblast growth factor; epidermal growth factor; heparin binding growth factors; phosphorothioate oligodeoxynucleotides; platelet derived growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; LACTATE DEHYDROGENASE; MITOGENIC AGENT; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PLATELET DERIVED GROWTH FACTOR; TETRAZOLIUM;

ANIMAL MODEL; AORTA; ARTERY INJURY; ARTICLE; CAROTID ARTERY; CELL MIGRATION; CELL PROLIFERATION; HUMAN; HUMAN CELL; INTIMA; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RAT; RESTENOSIS; VASCULAR SMOOTH MUSCLE;

EID: 9344269909     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118810     Document Type: Article

References (43)

1. Nobuyoshi, M., T. Kimura, H.S. Nosaka, S. Moika, K. Ueno, H. Yokui, N. Hamasaki, H. Horiuchi, and H. Ohishi. 1988. Restenosis after successful percutaneous transluminal coronary angioplasty: serial angiographic follow-up of 299 patients. J. Am. Coll. Cardiol. 12:616-623.
2. Popma, J.J., R.M. Califf, and E.J. Topol. 1991. Clinical trials of restenosis after coronary angioplasty. Circulation. 84:1426-1436.
3. Liu, M.W., G.S. Roubin, and S.B. King III. 1989. Restenosis after coronary angioplasty: potential biologic determinants and role of intimal hyperplasia. Circulation. 79:1374-1387.
4. Shi, Y., H.G. Hutchinson, D.J. Hall, and A. Zalewski. 1993. Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells. Circulation. 88:1190-1195.
5. Villa, A.E., L.A. Guzman, E.J. Poptic, V. Labhasetwar, S. D'Souza, C.L. Farrell, E.F. Plow, R.J. Levy, P.E. DiCorleto, and E.J. Topol. 1995. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ. Res. 76:505-513.
6. Stein, C.A., and Y.-C. Cheng. 1993. Antisense oligonucleotides as therapeutic agents - Is the bullet really magical? Science (Wash. DC). 261:1004-1012.
7. Bennett, M.R., S. Anglin, J.R. McEwan, R. Jagoe, A.C. Newby, and G.I. Evan. 1993. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligonucleotides. J. Clin. Invest. 93:820-828.
8. Shi, Y., A. Fard, A. Galeo, H.G. Hutchinson, P. Vernani, G.R. Dodge, D.J. Hall, F. Shaheen, and A. Zalewski. 1994. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation. 90:944-951.
9. Brown, K.E., M.S. Kindy, and G.E. Sonenshein. 1992. Expression of the c-myc protooncogene in bovine vascular smooth muscle cells. J. Biol. Chem. 267:4625-4630.
10. Simons, M., and R.D. Rosenberg. 1992. Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro. Circ. Res. 70:835-843.
11. Ebbecke, M., C. Unterberg, A. Buchwald, S. Stohr, and V. Wiegand. 1992. Antiproliferative effects of a c-myc antisense oligonucleotide on human arterial smooth muscle cells. Basic Res. Cardiol. 87:585-591.
12. Biro, S., Y.M. Fu, Z.X. Yu, and S.E. Epstein. 1993. Inhibitory effects of antisense oligonucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc. Natl. Acad. Sci. USA. 90:654-658.
13. Simons, M., E.R. Edelman, J.-L. DeKeyser, R. Langer, and R.D. Rosenberg. 1992. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature (Lond.). 359:67-70.
14. Burgess, T.L., E.F. Fisher, S.L. Ross, J.V. Bready, Y.-X. Qian, L.A. Bayewitch, A.M. Cohen, C.J. Herrera, S.S.-F. Hu, T.B. Kramer, et al. 1995. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc. Natl. Acad. Sci. USA. 92:4051-4055.
15. Guvakova, M.A., L.A. Yakubov, I. Vlodavsky, J.L. Tonkinson, and C.A. Stein. 1995. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J. Biol. Chem. 270:2620-2627.
16. Stein, C.A., C. Subasinghe, K. Shinozuka, and J. Cohen. 1988. Physiochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res. 16:3209-3221.
17. Yang, Z., G. Noll, and T.F. Luscher. 1993. Calcium antagonists differently inhibit proliferation of human coronary smooth muscle cells in response to pulsatile stretch and platelet-derived growth factor. Circulation. 88:832-836.
18. Franke, L., and T. Portmann. 1994. A highly sensitive non-radioactive cytotoxicity assay for human target cells. J. Immunol. Methods. 171:259-262.
19. Tada, H., O. Shiho, K. Kuroshima, M. Koyamam, and K. Tsukamotok. 1986. An improved colorimetric assay for interleukin-2. J. Immunol. Methods. 93:157-165.
20. Ferns, G.A.A., E.W. Raines, K.H. Sprugel, A.S. Montani, M.A. Reidy, and R. Ross. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science (Wash. DC). 253:1129-1132.
21. Jackson, C.L., and M.A. Reidy. 1992. The role of plasminogen activation in smooth muscle cell migration after arterial injury. Ann. NY Acad. Sci. 667:141-150.
22. Edelman, E.R., M.A. Nugent, L.T. Smith, and M.T. Karnovsky. 1992. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum injured arteries. J. Clin. Invest. 89:465-473.
23. Clowes, A.W., M.A. Reidy, and M.M. Clowes. 1983. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab. Invest. 49:327-333.
24. Edelman, E.R., D.H. Adams, and M.S. Karnovsky. 1990. Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc. Natl. Acad. Sci. USA. 87:3773-3777.
25. Ross, R., J. Glomset, B. Kariya, and L. Harker. 1974. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. USA. 71:1207-1210.
26. Raines, E.W., and R. Ross. 1982. Platelet-derived growth factor. I. High yield purification and evidence for multiple forms. J. Biol. Chem. 257:5154-5160.
27. Bachinsky, W.B., E.S. Barnathan, H. Liu, S.S. Okada, A. Kuo, P.N. Raghunath, M. Muttreja, R.J. Caron, J.E. Tomaszewski, P.B. Weisz, and M.A. Golden. 1995. Sustained inhibition of intimal thickening: In vitro and in vivo effects of polymeric β-cyclodextrin sulfate. J. Clin. Invest. 96:2583-2592.
28. Gao, W.-Y., C. Storm, W. Egan, and Y.-C. Cheng. 1992. Cellular pharmacology of phosphorothioate homooligodeoxynucleotides in human cells. Mol. Pharmacol. 43:45-50.
29. Jackson, C.L., E.W. Raines, R. Ross, and M.A. Reidy. 1993. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscler. Thromb. 13:1218-1226.
30. Lindner, V., D.A. Lappi, A. Baird, R.A. Majack, and M.A. Reidy. 1991. Role of basic fibroblast growth factor in vascular lesion formation. Circ. Res. 68: 106-113.
31. Soto, Y., R. Hamanaka, J. Ono, M. Kuwano, D.B. Rifkin, and R. Takaki. 1991. The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF. Biochem. Biophys. Res. Commun. 174:1260-1266.
32. Lindner, V., and M.A. Reidy. 1991. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA. 88:3739-3743.
33. Khaled, Z., L. Benimetskaya, R. Zeltser, T. Khan, H.W. Sharma, R. Narayanan, and C.A. Stein. 1996. Multiple mechanisms may contribute to the cellular antiadhesive effects of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res. 24:737-745.
34. Bennett, M.R., and S.M. Schwartz. 1995. Antisense therapy for angioplasty restenosis: some critical considerations. Circulation. 92:1981-1993.
35. Lengyel, P. 1982. Biochemistry of interferons and their actions. Annu. Rev. Biochem. 51:251-282.
36. Hansson, G.K., L. Jonasson, J. Holm, M.M. Clowes, and A.W. Clowes. 1988. γ-Interferon regulates vascular smooth muscle cell proliferation and Ia expression in vivo and in vitro. Circ. Res. 63:712-719.
37. Hansson, G.K., M. Hellstrand, L. Rymo, L. Rubbia, and G. Gabbiani. 1989. Interferon-γ inhibits both proliferation and expression of differentiation-specific α-smooth muscle actin in arterial smooth muscle cells. J. Exp. Med. 170: 1595-1608.
38. Hansson, G.K., and J. Holm. 1991. IFN-γ inhibits arterial stenosis after injury. Circulation. 84:1266-1272.
39. Wang, W.Z., H.J. Chen, K.N. Giedd, A. Schwartz, P.J. Cannon, and L.E. Rabbani. 1995. T cell lymphokines, interleukin-4 and gamma interferon, modulate the induction of vascular smooth muscle cell tissue plasminogen activator and migration by serum and platelet-derived growth factor. Circ. Res. 77: 1095-1106.
40. Morishita, R., G.H. Gibbons, K.E. Ellison, M. Nakajima, L. Zhang, Y. Kareda, T. Ogihara, and V.J. Dzau. 1993. Single intraluminal delivery of antisense cdc 2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad. Sci. USA. 90:8474-8478.
41. Morishita, R., G.H. Gibbons, K.E. Ellison, M. Nakajima, H. von der Leyen, L. Zhang, Y. Kareda, T. Ogihara, and V.J. Dzau. 1994. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J. Clin. Invest. 93:1458-1464.
42. Abe, J., W. Zhou, J. Taguchi, N. Takuwa, K. Miki, H. Okazaki, K. Kurokawa, M. Kumada, and Y. Takuwa. 1994. Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc 2 and cdk 2 oligonucleotides in rat carotid artery. Biochem. Biophys. Res. Commun. 198:16-24.
43. Simons, M., E.R. Edelman, and R.D. Rosenberg. 1994. Antisense proliferating-cell nuclear antigen oligonucleotides inhibit neointimal hyperplasia in a rat carotid artery injury model. J. Clin. Invest. 93:2351-2356.