A prospective randomized study to evaluate the effect of leukodepletion on the rate of alveolar production of exhaled nitric oxide during cardiopulmonary bypass

Annals of Thoracic Surgery

Volumn 78, Issue 6, 2004, Pages 2139-2145

  Alexiou, Christos ^a,d   Tang, Augustine T M ^a   Sheppard, Stuart V ^a   Haw, Marcus P ^a   Gibbs, Roz ^c   Smith, David C ^b  

^a Cardiac Surgery   (United States)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^d GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

25

Indexed keywords

NITRIC OXIDE; POLITEF;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ENDOTRACHEAL TUBE; FEMALE; HUMAN; LEUKOPENIA; LUNG ALVEOLUS; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FUNCTION; STATISTICAL SIGNIFICANCE; STERNOTOMY;

AGED; BREATH TESTS; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; FEMALE; FILTRATION; HUMANS; LEUKOCYTES; LEUKOPENIA; MALE; MIDDLE AGED; NITRIC OXIDE; PROSPECTIVE STUDIES; PULMONARY ALVEOLI;

EID: 9344257873     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2004.05.087     Document Type: Article

References (36)

1. L.H. Edmunds Jr Inflammatory response to cardiopulmonary bypass Ann Thorac Surg 66 5 Suppl 1998 S12 6 Discussion S258
2. L.H. Edmunds Jr The evolution of cardiopulmonary bypass: lessons to be learned Perfusion 17 2002 243 251
3. S.K. Ohri Systemic inflammatory response and the splachnic bed in cardiopulmonary bypass Perfusion 11 1996 200 212
4. G. Asimakopoulos The inflammatory response to cardiopulmonary bypass: the role of leucocyte filtration Perfusion 17 2002 7 10
5. S. Moncada, A. Higgs The L-arginine-nitric oxide pathway N Engl J Med 329 1993 2002 2012
6. P.J. Barnes, F.Y. Liew Nitric oxide and asthmatic inflammation Immunol Today 16 1995 128 130
7. C. Sartori, M. Lepori, T. Busch Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans Am J Respir Crit Care Med 160 1999 879 882
8. Schedin U, Frostell C, Persson MG, Jakobsson J, Andersson G, Gustafsson LE. Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans. 1995;39:327-32.
9. L.E. Gustafsson, A.M. Leone, M. Persson Endogenous nitric oxide is present in the exhaled air of rabbits, guinea-pigs, and humans Biochem Biophys Res Commun 181 1991 852 857
10. A.M. Leone, L.E. Gustafsson, P.L. Francis, M.G. Persson, P.G. Wijlund, S. Moncada Nitric oxide is present in exhaled air in humans: direct GS-MS confirmation Biochem Biophys Res Commun 201 1994 883 887
11. S.A. Kharitonov, D. Yates, R.A. Robbins Increased nitric oxide in exhaled air of asthmatic patients Lancet 343 1994 133 135
12. S. Kharitonov, P.J. Barnes Nitric oxide in exhaled air is a new marker of airway inflammation Arch Chest Dis 51 1996 533 537
13. G.E. Hill, S. Snider, T.A. Galbraith, S. Forst, R.A. Robbins Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass Am J Respir Crit Care Med 152 1995 1791 1795
14. S.J. Brett, G.J. Quinlan, J. Mitchell, J.R. Pepper, T.W. Evans Production of nitric oxide during surgery involving cardiopulmonary bypass Crit Care Med 26 1998 272 278
15. B.H. Guthbertson, S.A. Stott, N.R. Webster Exhaled nitric oxide as a marker of lung injury on coronary artery bypass surgery Br J Anaesth 89 2002 247 250
16. T. Kovesi, D. Royston, M. Yacoub, N. Marczin Basal and nitroglycerin-induced exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass Br J Anaesth 90 2003 608 616
17. N. Marczin, T. Kovesis, D. Royston, B.H. Cuthbertson, S.A. Stott, N.R. Webster Exhaled nitric oxide as a marker of lung injury in coronary artery bypass surgery Br J Anaesth 90 2003 101 105
18. Y. Ishibe, R. Liu, J. Hirosawa Exhaled nitric oxide level decreases after cardiopulmonary bypass in adult patients Crit Care Med 28 2000 3823 3827
19. T. Humpl, R. Campbell, D. Stephens Levels of exhaled nitric oxide before and after surgical and transcatheter device closure of atrial septal defects in children J Thorac Cardiovasc Surg 124 2002 806 810
20. W. Tworetzky, P. Moore, J.M. Bekker Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects J Am Coll Cardiol 35 2000 463 467
21. G.E. Hill, A. Ruggeroli, R. Pohorecki, A. Alonso, R.A. Robbins Cigarette smoking reduces endogenous airway nitric oxide production during cardiopulmonary bypass in humans Anesth Analg 81 1995 170 172
22. Alexiou C, Tang ATM, Sheppard SV, et al. The effect of leucodepletion on leucocyte activation, pulmonary inflammation and respiratory index in CABG: a prospective randomised clinical study. Eur J Cardiothorac Surg 2004;26:294@0017300.
23. J.C. Cendan, L.L. Moldawer, W.W. Souba, E.M. Copeland, D.C. Lind Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines Arch Surg 129 1994 1296 1300
24. T.E. Stewart, F. Valenza, S.P. Ribeiro Increased NO in exhaled gas as an early marker of lung inflammation in a model of sepsis Am J Respir Crit Care Med 151 1995 931 938
25. B.N. Mora, G.H. Boasquevisque, G. Uh Exhaled nitric oxide correlates with experimental lung transplant rejection Ann Thorac Surg 69 2000 210 215
26. E. Gabbay, E.H. Walters, B. Orsida In stable lung transplant recipients, exhaled nitric oxide levels positively correlate with airway neutrophilia and bronchial epithelial i-NOS Am J Respir Crit Care Med 160 1999 2093 2099
27. E. Gabbay, E.H. Walters, B. Orsida Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase Am J Respir Crit Care Med 162 2000 2182 2187
28. A.J. Fisher, E. Gabbay, T. Small Cross sectional study of exhaled nitric oxide levels following lung transplantation Thorax 53 1998 454 458
29. D.P. Taggart, M. El-Fiky, R. Carter, A. Bowman, D.J. Wheatley Respiratory dysfunction after uncomplicated cardiopulmonary bypass Ann Thorac Surg 56 1993 1123 1128
30. D.P. Taggart Respiratory dysfunction after cardiac surgery: effects of avoiding cardiopulmonary bypass and the use of bilateral internal mammary arteries Eur J Cardiothorac Surg 18 2000 31 37
31. G. Asimakopoulos, P.L.C. Smith, C.P. Ratnatunga, K.M. Taylor Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass Ann Thorac Surg 68 1999 1107 1115
32. Y.J. Gu, A.J. deVries, P.W. Boonstra, W. van Oeveren Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery J Thorac Cardiovasc Surg 112 1996 494 500
33. T. Mihaljevic, M. Tonz, L.K. Von-Segesser The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function: a clinical study J Thorac Cardiovasc Surg 109 1995 1138 1145
34. N. Marczin Exhaled nitric oxide and cardiac surgery with extracorporeal circulation J Thorac Cardiovasc Surg 126 2003 1673 1674
35. S.J. Brett, T.W. Evans Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome Am J Respir Crit Care Med 157 1998 993 997
36. R.W. Hyde, E.J. Geigel, J.A. Olszowka Determination of production of nitric oxide by lower airways of humans: theory J Appl Physiol 82 1997 1290 1296