Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3- pyridyl)alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase

Journal of Medicinal Chemistry

Volumn 39, Issue 16, 1996, Pages 3148-3157

  Hibi, Shigeki ^a   Okamoto, Yasushi ^a   Tagami, Katsuya ^a   Numata, Hirotoshi ^a   Kobayashi, Naoki ^a   Shinoda, Masanobu ^a   Kawahara, Tetsuya ^a   Harada, Koukichi ^a   Miyamoto, Kaname ^a   Yamatsu, Isao ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID DERIVATIVE; ARACHIDONATE 5 LIPOXYGENASE; THROMBOXANE SYNTHASE;

ARACHIDONIC ACID METABOLISM; ARTICLE; DRUG ABSORPTION; ENZYME INHIBITION; INFLAMMATORY CELL; MEDIATOR RELEASE; MINIMUM INHIBITORY CONCENTRATION; NEPHROSIS; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOQUINONES; BLOOD PLATELETS; CELLS, CULTURED; HUMANS; HYDROXYUREA; LEUKOTRIENE B4; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; METHACRYLATES; MOLECULAR STRUCTURE; NEUTROPHILS; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE B2; THROMBOXANE-A SYNTHASE;

EID: 9344254370     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950725r     Document Type: Article

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