메뉴 건너뛰기




Volumn 7, Issue 2, 1996, Pages 94-100

Cellular and molecular biology of vascular remodeling

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; RECEPTOR; VASCULOTROPIN;

EID: 9344252212     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199604000-00008     Document Type: Review
Times cited : (66)

References (54)
  • 1
    • 0029015923 scopus 로고
    • Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
    • Dumont DJ, Fong G-H, Puri MC, Gradwohl G, Alitalo K, Breitman ML: Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev Dyn 1995, 203:80-92.
    • (1995) Dev Dyn , vol.203 , pp. 80-92
    • Dumont, D.J.1    Fong, G.-H.2    Puri, M.C.3    Gradwohl, G.4    Alitalo, K.5    Breitman, M.L.6
  • 2
    • 0026593331 scopus 로고
    • Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
    • Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992, 114:521-532.
    • (1992) Development , vol.114 , pp. 521-532
    • Breier, G.1    Albrecht, U.2    Sterrer, S.3    Risau, W.4
  • 3
    • 0029317445 scopus 로고
    • Vascular endothelial growth factor: The trigger for neovascularization in the eye
    • Ferrara N: Vascular endothelial growth factor: the trigger for neovascularization in the eye. Lab Invest 1995, 72:615-618.
    • (1995) Lab Invest , vol.72 , pp. 615-618
    • Ferrara, N.1
  • 4
  • 5
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • ••] demonstrate critical but distinct roles for two VEGF receptors in early vascular development. The authors developed flk-1 null mutant mice by disrupting the gene using homologous recombination in embryonic stem cells. Endothelial cells of homozygous mice did not fully differentiate; they expressed the early endothelial cell marker, tek, but failed to display markers of later differentiation and functional blood vessels did not develop. Thus flk-1 appears to be important in differentiation of the endothelial cell lineage.
    • (1995) Nature (Lond) , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3    Gertsenstein, M.4    Wu, X.-F.5    Breitman, M.L.6    Schuh, A.C.7
  • 6
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G-H, Rossant J, Gertsenstein M, Breitman ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70. Endothelial cells differentiated in mice homozygous for flt-1 null mutation, but formed abnormally large vascular channels. Also, endothelial cells were observed in the lumen of the blood islands and vessels, as well as lining these structures. Thus flt-1 appears important in assembly of endothelial cells into organized blood vessels.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.-H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 7
    • 0028122465 scopus 로고
    • Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    • •] targeted two related, endothelial cell-specific RTKs whose ligands are unknown. In this study, null mutations and dominant negative mutations of tek did not appear to impair normal vascular patterning but suppressed numbers of endothelial cells, suggesting that tek is important in endothelial cell proliferation and survival.
    • (1994) Genes Dev , vol.8 , pp. 1897-1909
    • Dumont, D.J.1    Gradwohl, G.2    Fong, G.-H.3    Puri, M.C.4    Gertsenstein, M.5    Auerbach, A.6    Breitman, M.L.7
  • 8
    • 0029001244 scopus 로고
    • Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
    • Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y: Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995, 376:70-74. When mutations of tie (tie-1) and tek (tie-2) were compared, tie mutation was found to lead to severe edema that led to neonatal death, apparently caused by pulmonary dysfunction, a finding that suggests a role for Tie in endothelial permeability barrier function. By contrast, these investigators report that tek led to failure of large vessels to develop from capillary plexuses. Impaired angiogenesis was also reported, although this appeared to be based partly on misinterpretation of cells lining ventricular trabeculae as coronary endothelium.
    • (1995) Nature , vol.376 , pp. 70-74
    • Sato, T.N.1    Tozawa, Y.2    Deutsch, U.3    Wolburg-Buchholz, K.4    Fujiwara, Y.5    Gendron-Maguire, M.6    Gridley, T.7    Wolburg, H.8    Risau, W.9    Qin, Y.10
  • 11
    • 0011412533 scopus 로고
    • Chronic effects of blood flow on the artery wall
    • Edited by Frangos JA. San Diego: Academic Press
    • Langille BL: Chronic effects of blood flow on the artery wall. In Physical forces and the mammalian cell. Edited by Frangos JA. San Diego: Academic Press; 1993:249-274.
    • (1993) Physical Forces and the Mammalian Cell , pp. 249-274
    • Langille, B.L.1
  • 12
    • 0029087961 scopus 로고
    • Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor
    • Kanai AJ, Strauss HC, Truskey GA, Crews AL, Grunfeld S, Malinski T: Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res 1995, 77:284-293.
    • (1995) Circ Res , vol.77 , pp. 284-293
    • Kanai, A.J.1    Strauss, H.C.2    Truskey, G.A.3    Crews, A.L.4    Grunfeld, S.5    Malinski, T.6
  • 13
    • 0028878919 scopus 로고
    • Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress
    • Ranjan V, Xiao Z, Diamond SL: Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol 1995, 269:H550-H555.
    • (1995) Am J Physiol , vol.269
    • Ranjan, V.1    Xiao, Z.2    Diamond, S.L.3
  • 14
    • 0027410814 scopus 로고
    • Remodelling of developing and mature arteries: Endothelium, smooth muscle and matrix
    • Langille BL: Remodelling of developing and mature arteries: endothelium, smooth muscle and matrix. J Cardiovasc Pharmacol 1993, 21: S11-S17.
    • (1993) J Cardiovasc Pharmacol , vol.21
    • Langille, B.L.1
  • 15
    • 0025912717 scopus 로고
    • Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells
    • Sharefkin JB, Diamond SL, Eskin SG, McIntire LV: Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells. J Vasc Surg 1991, 14:1-9.
    • (1991) J Vasc Surg , vol.14 , pp. 1-9
    • Sharefkin, J.B.1    Diamond, S.L.2    Eskin, S.G.3    McIntire, L.V.4
  • 16
    • 0024558347 scopus 로고
    • Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow
    • Langille BL, Bendeck MP, Keeley FW: Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am J Physiol 1989, 256:H931-H939.
    • (1989) Am J Physiol , vol.256
    • Langille, B.L.1    Bendeck, M.P.2    Keeley, F.W.3
  • 17
    • 0028954468 scopus 로고
    • Apoptosis (programmed cell death) in arteries of the neonatal lamb
    • Cho A, Courtman DW, Langille BL: Apoptosis (programmed cell death) in arteries of the neonatal lamb. Circ Res 1995, 76:168-175. Degradation of DNA into oligonucleosomes, in-situ end-labelling of fragmented DNA, in-vivo uptake of propidium iodide and condensation of nuclear chromatin were used to show that the extensive remodeling of arteries in the perinatal period involves cell death, and specificially apoptosis. This finding implicated apoptosis in arterial remodeling late in development, and demonstrated that assessments of cell replication rates alone can give a misleading picture of arterial growth control.
    • (1995) Circ Res , vol.76 , pp. 168-175
    • Cho, A.1    Courtman, D.W.2    Langille, B.L.3
  • 18
    • 0028566360 scopus 로고
    • Perinatal accumulation of arterial wall constituents: Relation to hemodynamic changes at birth
    • Bendeck MP, Keeley FW, Langille BL: Perinatal accumulation of arterial wall constituents: relation to hemodynamic changes at birth. Am J Physiol 1994, 267:H2268-H2279.
    • (1994) Am J Physiol , vol.267
    • Bendeck, M.P.1    Keeley, F.W.2    Langille, B.L.3
  • 19
    • 0028262484 scopus 로고
    • Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta
    • Davis EC: Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta. J Cell Sci 1994, 107:727-736.
    • (1994) J Cell Sci , vol.107 , pp. 727-736
    • Davis, E.C.1
  • 20
    • 0028825416 scopus 로고
    • Elastic lamina growth in the developing mouse aorta
    • Davis EC: Elastic lamina growth in the developing mouse aorta. J Histochem Cytochem 1995, 43: 1115-1123.
    • (1995) J Histochem Cytochem , vol.43 , pp. 1115-1123
    • Davis, E.C.1
  • 21
    • 0028040868 scopus 로고
    • The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin
    • Zhu L, Wigle D, Hinek A, Kobayashi J, Ye C, Zuker M, Dodo H, Keeley FW, Rabinovitch M: The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin. J Clin Invest 1994, 94:1163-1171. Degenerate sequences common to serine elastases were used to amplify by polymerase chain reaction an endogenous vascular elastase from rat pulmonary artery cDNA. The enzyme is present in developing arteries, suggesting a role in developmental arterial remodeling, and transcript levels were tripled when elastolytic activity was increased during experimental hypertension, which implicated the elastase in pathologic remodeling processes.
    • (1994) J Clin Invest , vol.94 , pp. 1163-1171
    • Zhu, L.1    Wigle, D.2    Hinek, A.3    Kobayashi, J.4    Ye, C.5    Zuker, M.6    Dodo, H.7    Keeley, F.W.8    Rabinovitch, M.9
  • 22
    • 0029072762 scopus 로고
    • Flow-mediated endothelial mechanotransduction
    • Davies PF: Flow-mediated endothelial mechanotransduction. Physiol Rev 1995, 75:519-560. An exhaustive and thoughtful review of potential mechanisms by which endothelial cells sense changes in the rates of blood flow they deliver to peripheral tissues, and the way in which downstream intracellular events may be controlled.
    • (1995) Physiol Rev , vol.75 , pp. 519-560
    • Davies, P.F.1
  • 23
    • 0028823506 scopus 로고
    • Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells
    • Tseng H, Peterson TE, Berk BC: Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ Res 1995, 77:869-878.
    • (1995) Circ Res , vol.77 , pp. 869-878
    • Tseng, H.1    Peterson, T.E.2    Berk, B.C.3
  • 24
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG: The MAPK signaling cascade. FASEB J 1995, 9:726-735
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 26
    • 0028982830 scopus 로고
    • Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress
    • •] provide the first data on specific transcriptional regulators of shear-induced gene expression. In both cases, the transcription factors (NF-κB and an AP-1 site) are known to regulate expression of many genes under diverse conditions. The pathways by which they are activated by shear stress, and the means by which shear-induced genes are selectively targeted when blood flow changes, are critical questions for future work.
    • (1995) J Clin Invest , vol.96 , pp. 1169-1175
    • Khachigian, L.M.1    Resnick, N.2    Gimbrone Jr., M.A.3    Collins, T.4
  • 28
    • 0028957211 scopus 로고
    • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade
    • Ohno M, Cooke JP, Dzau VJ, Gibbons GH: Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. J Clin Invest 1995, 95:1363-1369.
    • (1995) J Clin Invest , vol.95 , pp. 1363-1369
    • Ohno, M.1    Cooke, J.P.2    Dzau, V.J.3    Gibbons, G.H.4
  • 29
    • 0029005508 scopus 로고
    • Nitric oxide and cGMP analogs activate transcription from AP-1 responsive promoters in mammalian cells
    • Piłz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR: Nitric oxide and cGMP analogs activate transcription from AP-1 responsive promoters in mammalian cells. FASEB J 1995, 9:552-558.
    • (1995) FASEB J , vol.9 , pp. 552-558
    • Piłz, R.B.1    Suhasini, M.2    Idriss, S.3    Meinkoth, J.L.4    Boss, G.R.5
  • 30
    • 0024793652 scopus 로고
    • Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells
    • Owens GK: Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells. Am J Physiol 1989, 257:H1755-H1765.
    • (1989) Am J Physiol , vol.257
    • Owens, G.K.1
  • 31
    • 0009477295 scopus 로고
    • Dynamic responses of collagen and elastin to vessel wall perturbation
    • Edited by Gotlieb AI, Langille BL and Fedoroff S. New York: Plenum Press
    • Keeley FW: Dynamic responses of collagen and elastin to vessel wall perturbation. In Atherosclerosis: cellular and molecular interactions in the artery wall. Edited by Gotlieb AI, Langille BL and Fedoroff S. New York: Plenum Press; 1991:101-114.
    • (1991) Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall , pp. 101-114
    • Keeley, F.W.1
  • 32
    • 0020117867 scopus 로고
    • Physiological aspects of primary hypertension
    • Folkow B: Physiological aspects of primary hypertension. Physiol Rev 1982, 62:347-497.
    • (1982) Physiol Rev , vol.62 , pp. 347-497
    • Folkow, B.1
  • 33
  • 34
    • 0028941383 scopus 로고
    • Loss of flow-dependent coronary artery dilatation in patients with hypertension
    • Antony I, Lerebours G, Nitenberg A: Loss of flow-dependent coronary artery dilatation in patients with hypertension. Circulation 1995, 91:1624-1628.
    • (1995) Circulation , vol.91 , pp. 1624-1628
    • Antony, I.1    Lerebours, G.2    Nitenberg, A.3
  • 35
    • 0026589784 scopus 로고
    • Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells
    • Davis MJ, Donovitz JA, Hood JD: Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells. Am J Physiol Cell Physiol 1992, 262:C1083-C1088.
    • (1992) Am J Physiol Cell Physiol , vol.262
    • Davis, M.J.1    Donovitz, J.A.2    Hood, J.D.3
  • 37
    • 0028104326 scopus 로고
    • Mechanical stretch increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells
    • Lyall F, Deehan MR, Greer IA, Boswell F, Brown WC, McInnes GT: Mechanical stretch increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells. J Hypertens 1994, 12:1139-1145.
    • (1994) J Hypertens , vol.12 , pp. 1139-1145
    • Lyall, F.1    Deehan, M.R.2    Greer, I.A.3    Boswell, F.4    Brown, W.C.5    McInnes, G.T.6
  • 38
    • 0028906470 scopus 로고
    • Activation of mitogen-activated protein kinase in porcine carotid arteries
    • Adam LP, Franklin MT, Raff GJ, Hathaway DR: Activation of mitogen-activated protein kinase in porcine carotid arteries. Circ Res 1995, 76:183-190.
    • (1995) Circ Res , vol.76 , pp. 183-190
    • Adam, L.P.1    Franklin, M.T.2    Raff, G.J.3    Hathaway, D.R.4
  • 39
    • 0025301697 scopus 로고
    • Effect of static stretching on elastin production by porcine aortic smooth muscle cells
    • Sutcliffe MC, Davidson JM: Effect of static stretching on elastin production by porcine aortic smooth muscle cells. Matrix 1990, 10: 148-153.
    • (1990) Matrix , vol.10 , pp. 148-153
    • Sutcliffe, M.C.1    Davidson, J.M.2
  • 40
    • 0028940929 scopus 로고
    • Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy
    • Negoro N, Kanayama Y, Haraguchi M, Umetani N, Nishimura M, Konishi Y, Iwai J, Okamura M, Inoue T, Takeda T: Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy. J Clin Invest 1995, 95:1140-1150. Stimulated by evidence that mitogenic effects of a number of agents may be mediated by the PDGF-A-chain, these investigators assessed the role of this growth factor in the arterial wall hypertrophy of hypertension, a process that is poorly understood at the molecular level. They showed upregulation of A-chain mRNA levels in arteries of spontaneously hypertensive rats and demonstrated that levels of the transcriptional activator, Sp1, and its interaction with the A-chain promoter, were sensitive to manipulations of blood pressure. The data thus suggest a role for PDGF-A-chain, and its regulation via Sp1, in the wall thickening of hypertension.
    • (1995) J Clin Invest , vol.95 , pp. 1140-1150
    • Negoro, N.1    Kanayama, Y.2    Haraguchi, M.3    Umetani, N.4    Nishimura, M.5    Konishi, Y.6    Iwai, J.7    Okamura, M.8    Inoue, T.9    Takeda, T.10
  • 41
    • 0029115152 scopus 로고
    • Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1b-converting enzyme
    • Geng Y-J, Libby P: Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1b-converting enzyme. Am J Pathol 1995, 147:251-266.
    • (1995) Am J Pathol , vol.147 , pp. 251-266
    • Geng, Y.-J.1    Libby, P.2
  • 42
    • 0028023501 scopus 로고
    • Cell proliferation and collagen synthesis are two independent events in human atherosclerotic plaques
    • Rekhter MD, Gordon D: Cell proliferation and collagen synthesis are two independent events in human atherosclerotic plaques. J Vasc Res 1994, 31:280-286.
    • (1994) J Vasc Res , vol.31 , pp. 280-286
    • Rekhter, M.D.1    Gordon, D.2
  • 43
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994, 94: 2493-2503. This study demonstrated the focal presence of the matrix metalloproteinases, interstitial collagenase, 92 kD gelatinase and stromelysin of human atherosclerotic lesions. The findings are strongly suggestive of ongoing remodeling of lesion tissues, and of a possible source of plaque rupture. A particular strength of this study was the use of immunocytochemistry to identify the enzymes, combined with convincing in-situ zymography, to demonstrate active enzyme rather than precursor or enzyme that is inhibited by endogenous tissue inhibitors of metalloproteinases.
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 45
    • 0022627158 scopus 로고
    • Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates
    • Freiman PC, Mitchell GG, Heistad DD, Armstrong ML, Harrison DG: Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ Res 1986, 58:783-789.
    • (1986) Circ Res , vol.58 , pp. 783-789
    • Freiman, P.C.1    Mitchell, G.G.2    Heistad, D.D.3    Armstrong, M.L.4    Harrison, D.G.5
  • 46
    • 0028919777 scopus 로고
    • Paradoxical arterial wall shrinkage may contribute to luminal narrowing of human atherosclerotic femoral arteries
    • Pasterkamp G, Wensing PJW, Post MJ, Hillen B, Mali WPTM, Borst C: Paradoxical arterial wall shrinkage may contribute to luminal narrowing of human atherosclerotic femoral arteries. Circulation 1995, 91:1444-1449.
    • (1995) Circulation , vol.91 , pp. 1444-1449
    • Pasterkamp, G.1    Wensing, P.J.W.2    Post, M.J.3    Hillen, B.4    Mali, W.P.T.M.5    Borst, C.6
  • 47
    • 0028855191 scopus 로고
    • Restenosis after percutaneous transluminal coronary angioplasty: Have we been aiming at the wrong target?
    • Currier JW, Faxon DP: Restenosis after percutaneous transluminal coronary angioplasty: have we been aiming at the wrong target? J Am Coll Cardiol 1995, 25:516-520.
    • (1995) J Am Coll Cardiol , vol.25 , pp. 516-520
    • Currier, J.W.1    Faxon, D.P.2
  • 49
    • 0028240851 scopus 로고
    • Vascular remodeling: Honey, I think I shrunk the artery
    • Isner JM: Vascular remodeling: honey, I think I shrunk the artery, Circulation 1994, 89:2937-2941.
    • (1994) Circulation , vol.89 , pp. 2937-2941
    • Isner, J.M.1
  • 51
    • 0029051673 scopus 로고
    • Restenosis after experimental angioplasty. Intimal, medial, and adventilial changes associated with constrictive remodeling
    • Lafont A, Guzman LA, Whitlow PL, Goormastic M, Cornhill JF, Chisolm GM: Restenosis after experimental angioplasty. Intimal, medial, and adventilial changes associated with constrictive remodeling. Circe Res 1995, 76:996-1002.
    • (1995) Circe Res , vol.76 , pp. 996-1002
    • Lafont, A.1    Guzman, L.A.2    Whitlow, P.L.3    Goormastic, M.4    Cornhill, J.F.5    Chisolm, G.M.6
  • 52
    • 0024594861 scopus 로고
    • Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation
    • Booth RFG, Martin JF, Honey AC, Hassall DG, Beesley JE, Moncada S: Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis 1989, 76:257-268.
    • (1989) Atherosclerosis , vol.76 , pp. 257-268
    • Booth, R.F.G.1    Martin, J.F.2    Honey, A.C.3    Hassall, D.G.4    Beesley, J.E.5    Moncada, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.