Structural bases of the redox-dependent conformational switch in the serpin PAI-2

Journal of Molecular Biology

Volumn 344, Issue 5, 2004, Pages 1359-1368

  Lobov, Sergei ^a   Wilczynska, Malgorzata ^a   Bergström, Fredrik ^a   Johansson, Lennart B Å ^a   Ny, Tor ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

homo transfer; PAI 2; redox; serpin; vitronectin

Indexed keywords

MATRIX PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 2; SERINE PROTEINASE INHIBITOR; VITRONECTIN;

ARTICLE; CONFORMATIONAL TRANSITION; DISULFIDE BOND; MUTATION; OXIDATION REDUCTION REACTION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

HOMO;

EID: 9344241444     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.10.010     Document Type: Article

References (46)

1. P.E. Stein, A.G. Leslie, T. Finch, W.G. Turnell, P.J. McLaughlin, and R.W. Carrell Crystal structure of ovalbumin as a model for the reactive centre of serpins Nature 347 1990 99 102
2. G.A. Silverman, P.I. Bird, R.W. Carrell, F.C. Church, P.B. Coughlin, and P.G. Gettins The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature J. Biol. Chem. 276 2001 33293 33296
3. M. Wilczynska, M. Fa, P-I. Ohlsson, and T. Ny Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex J. Biol. Chem. 270 1995 29652 29655
4. M. Fa, F. Bergstrom, P. Hagglof, M. Wilczynska, L.B-Å. Johansson, and T. Ny The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites Struct. Fold. Des. 8 2000 397 405
5. J.A. Huntington, R.J. Read, and R.W. Carrell Structure of a serpin-protease complex shows inhibition by deformation Nature 407 2000 923 926
6. P.E. Stein, and R.W. Carrell What do dysfunctional serpins tell us about molecular mobility and disease? Nature Struct. Biol. 2 1995 96 113
7. D.A. Lomas, D.L. Evans, J.T. Finch, and R.W. Carrell The mechanism of Z alpha 1-antitrypsin accumulation in the liver Nature 357 1992 605 607
8. A. Wohlwend, D. Belin, and J.D. Vassalli Plasminogen activator-specific inhibitors produced by human monocytes/macrophages J. Expt. Med. 165 1987 320 339
9. P.J. Jensen, Q. Wu, P. Janowitz, Y. Ando, and N.M. Schechter Plasminogen activator inhibitor type 2: an intracellular keratinocyte differentiation product that is incorporated into the cornified envelope Expt. Cell. Res. 217 1995 65 71
10. T.C. Wun, and E. Reich An inhibitor of plasminogen activation from human placenta. Purification and characterization J. Biol. Chem. 262 1987 3646 3653
11. K.P. Radtke, K.H. Wenz, and N. Heimburger Isolation of plasminogen activator inhibitor-2 (PAI-2) from human placenta. Evidence for vitronectin/PAI-2 complexes in human placenta extract Biol. Chem. 371 1990 1119 1127
12. D. Belin, A. Wohlwend, W.D. Schleuning, E.K. Kruithof, and J.D. Vassalli Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activator inhibitor 2 EMBO J. 8 1989 3287 3294
13. G. von Heijne, P. Liljestrom, P. Mikus, H. Andersson, and T.J. Ny The efficiency of the uncleaved secretion signal in the plasminogen activator inhibitor type 2 protein can be enhanced by point mutations that increase its hydrophobicity J. Biol. Chem. 266 1991 15240 15243
14. B.C. Risse, H. Brown, R.M. Lavker, J.M. Pearson, M.S. Baker, D. Ginsburg, and P.J. Jensen Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2) Histochem. Cell. Biol. 110 1998 559 569
15. M.A. Liew, V. McPhun, and M.S. Baker Topological localization of plasminogen activator inhibitor type 2 Cytometry 40 2000 32 41
16. P.H. Jensen Structure and function of plasminogen activator inhibitor-2: An intracellular serine proteinase inhibitor modulating apoptosis Int. J. Oncol. 11 1997 557 570
17. S. Kumar, and C. Baglioni Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2 J. Biol. Chem. 266 1991 20960 20964
18. J.L. Dickinson, E.J. Bates, A. Ferrante, and T.M. Antalis Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function J. Biol. Chem. 270 1995 27894 278904
19. B.C. Risse, N.M. Chung, M.S. Baker, and P.J. Jensen Evidence for intracellular cleavage of plasminogen activator inhibitor type 2 (PAI-2) in normal epidermal keratinocytes J. Cell. Physiol. 182 2000 281 289
20. F.L. Scott, H.J. Eyre, M. Lioumi, J. Ragoussis, J.A. Irving, G.A. Sutherland, and P.I. Bird Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25 Genomics 62 1999 490 499
21. S.J. Harrop, L. Jankova, M. Coles, D. Jardine, J.S. Whittaker, and A.R. Gould The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function Struct. Fold. Des. 7 1999 43 54
22. P.H. Jensen, L. Lorand, P. Ebbesen, and J. Gliemann Type-2 plasminogen-activator inhibitor is a substrate for trophoblast transglutaminase and factor XIIIa. Transglutaminase-catalyzed cross-linking to cellular and extracellular structures Eur. J. Biochem. 214 1993 141 146
23. P.H. Jensen, E. Schuler, G. Woodrow, M. Richardson, N. Goss, and P. Hojrup A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking J. Biol. Chem. 269 1994 15394 15398
24. H. Ritchie, L.C. Lawrie, P.W. Crombie, M.W. Mosesson, and N.A. Booth Cross-linking of plasminogen activator inhibitor 2 and alpha 2-antiplasmin to fibrin(ogen) J. Biol. Chem. 275 2000 24915 24920
25. P.H. Jensen, T.G. Jensen, W.E. Laug, H. Hager, J. Gliemann, and B. Pepinsky The exon 3 encoded sequence of the intracellular serine proteinase inhibitor plasminogen activator inhibitor 2 is a protein binding domain J. Biol. Chem. 271 1996 26892 26899
26. G.A. Darnell, T.M. Antalis, R.W. Johnstone, B.W. Stringer, S.M. Ogbourne, D. Harrich, and A. Suhrbier Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif Mol. Cell. Biol 23 2003 6520 6532
27. J.L. Dickinson, B.J. Norris, P.H. Jensen, and T.M. Antalis The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis Cell Death Differ. 5 1998 163 171
28. A. Zhou, J.A. Huntington, N.S. Pannu, R.W. Carrell, and R.J. Read How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration Nature Struct. Biol. 10 2003 541 544
29. S. Stefansson, S. Muhammad, X.F. Cheng, F.D. Battey, D.K. Strickland, and D.A. Lawrence Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein J. Biol. Chem. 273 1998 6358 6366
30. T.L. Chuang, and R. Schleef Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10 J. Biol. Chem. 274 1999 11194 11198
31. S.A. Grigoryev, J. Bednar, and L. Voodcock MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member J. Biol. Chem. 274 1999 5626 5636
32. E.M. Springhetti, N.E. Istomina, J.C. Whisstock, T. Nikitina, C.L. Woodcock, and S.A. Grigoryev Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT J. Biol. Chem. 278 2003 43384 43393
33. P. Mikus, and T. Ny Intracellular polymerization of the serpin plasminogen activator inhibitor type 2 J. Biol. Chem. 271 1996 10048 10053
34. M. Wilczynska, S. Lobov, P-I. Ohlsson, and T. Ny A redox-sensitive loop regulates plasminogen activator inhibitor type-2 (PAI-2) polymerization EMBO J. 22 2003 1753 1761
35. M. Wilczynska, S. Lobov, and T. Ny The spontaneous polymerization of plasminogen activator inhibitor type-2 and Z-antitrypsin are due to different molecular aberrations FEBS Letters 537 2003 11 16
36. F. Bergström, P. Hägglöf, J. Karolin, T. Ny, and L.B.-Å. Johansson The use of site-directed fluorophore labeling and donor-donor energy migration to investigate solution structure and dynamics in proteins Proc. Natl Acad. Sci. USA 92 1999 12477 12481
37. N. Guex, A. Diemand, and M.C. Peitsch Protein modelling for all TiBS 24 1999 364 367
38. M. Isaksson, S. Kalinin, S. Lobov, S. Wang, T. Ny, and L.B.-Å. Johansson Partial donor-donor energy migration (PDDEM): A novel fluorescrnce method for internal protein distance measurements Phys. Chem. Chem. Phys. 6 2004 3001 3008
39. V.I. Abkevich, A.M. Gutin, and E.I. Shakhnovich Theory of kinetic partitioning in protein folding with possible applications to prions Proteins: Struct. Funct. Genet. 31 1998 335 344
40. B. Dahlback, and E.R. Podack Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group Biochemistry 24 1985 2368 2374
41. Y. Milev, and D.W. Essex Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of thrombospondin-1 with thrombin-antithrombin III Arch. Biochem. Biophys. 361 1999 120 126
42. D.W. Essex, A. Miller, M. Swiatkowska, and R.D. Feinman Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of vitronectin with thrombin-antithrombin Biochemistry 38 1999 10398 10405
43. M. Zheng, F. Aslund, and G. Storz Activation of the OxyR transcription factor by reversible disulfide bond formation Science 279 1998 1718 1721
44. U. Jakob, W. Muse, M. Eser, and J.C. Bardwell Chaperone activity with a redox switch Cell 96 1999 341 352
45. C. Nathan Points of control in inflammation Nature 420 2002 846 852
46. Y.S. Nkabyo, T.R. Ziegler, L.H. Gu, H. Watson, and D.P. Jones Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells Am. J. Physiol. Gastrointest. Liver Physiol. 283 2002 G1352 G1359