Feasibility of an antiviral clinical trial requiring cross-country shipment of conjunctival adenovirus cultures and recovery of infectious virus

Current Eye Research

Volumn 29, Issue 2-3, 2004, Pages 195-199

  Romanowski, Eric G ^a,e   Bartels, Stephen P ^b   Vogel, Roger ^c   Wetherall, Neal T ^d   Hodges Savola, Cheryl ^d   Kowalski, Regis P ^a   Yates, Kathleen A ^a   Kinchington, Paul R ^a   Gordon, Y Jerold ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BAUSCH AND LOMB   (United States)

^c Clinicor Inc   (United States)

^d ViroMed Laboratories Inc Minnesota   (United States)

^e University of Pittsburgh School of Medicine   (United States)

Author keywords

Adenovirus; Cultures; Feasibility study

Indexed keywords

VIRUS ANTIGEN;

ADENOVIRUS; CLINICAL TRIAL; CONFERENCE PAPER; CONJUNCTIVA; CONJUNCTIVAL CULTURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENVIRONMENTAL TEMPERATURE; FEASIBILITY STUDY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HUMAN TISSUE; LABORATORY DIAGNOSIS; MULTICENTER STUDY; PRIORITY JOURNAL; STORAGE TEMPERATURE; STORAGE TIME; TISSUE CULTURE; TRANSPORT MEDIUM; VIRUS CULTURE; VIRUS DIAGNOSIS; VIRUS ISOLATION; VIRUS TRANSPORT MEDIUM; VIRUS TYPING;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; AIRCRAFT; ANTIVIRAL AGENTS; CLINICAL TRIALS; CONJUNCTIVA; CONJUNCTIVITIS; FEASIBILITY STUDIES; HUMANS; MINNESOTA; MULTICENTER STUDIES; PENNSYLVANIA; SEROTYPING; SPECIMEN HANDLING; TEMPERATURE; TIME FACTORS;

EID: 9344240487     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680490504830     Document Type: Conference Paper

References (27)

1. Gordon JS, Aoki K, Kinchington PR. Adenovirus keratoconjunctivitis. In: Pepose J, Wilhelmus K, Holland G, editors. Ocular Infection and Immunity. St Louis: Mosby; 1996:877-894.
2. Nagl M, Teuchner B, Pottinger E, Ulmer H, Gottardi W. Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis - a phase II pilot study. Ophthalmologica. 2000;214:111-114.
3. Epstein SP, Pashinsky YY, Winicov I, Asbell PA. Topical cobalt chelate CTC-96 for the treatment of adenovirus conjunctivitis in a rabbit model. IOVS 2003;44:ARVO E-Abstract 4650.
4. Kaneko H, Kato K, Mori S, Shigeta S. Antiviral activity of NMSO3 against adenovirus in vitro. Antiviral Res. 2001;52:281-288.
5. Kaneko H, Mori S, Shigeta S, Ohno S, Aoki K. [Antiviral effect of sulfated sialyl lipid against a clinical strain of adenovirus]. Nippon Ganka Gakkai Zasshi. 2003;107:196-201.
6. Romanowski EG, Yates KA, Heiry M, Gordon YJ. Beyond cidofovir the in vitro evaluation of newer potential antiviral agents against ocular isolates of adenovirus. Invest Ophthalmol Vis Sci. 2001;42:S579.
7. Rietveld RP, van Weert HC, ter Riet G, Bindels PJ. Diagnostic impact of signs and symptoms in acute infectious conjunctivitis: systematic literature search. BMJ. 2003;327:789.
8. Hillenkamp J, Reinhard T, Ross RS, Bohringer D, Cartsburg O, Roggendorf M, De Clercq E, Godehardt E, Sundmacher R. Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study. Arch Ophthalmol. 2001;119:1487-1491.
9. Hillenkamp J, Reinhard T, Ross RS, Bohringer D, Cartsburg O, Roggendorf M, De Clercq E, Godehardt E, Sundmacher R, The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis; A controlled clinical pilot study. Ophthalmology. 2002;109:845-850.
10. Abad FX, Pinto RM, Bosch A, Survival of enteric viruses on environmental fomites. Appl Environ Microbiol. 1994;60:3704-3710.
11. Gordon YJ, Gordon RY, Romanowski E, Araullo-Cruz TP. Prolonged recovery of desiccated adenoviral serotypes 5, 8, and 19 from plastic and metal surfaces in vitro. Ophthalmology. 1993;100:1835-1839; discussion 1839-1840.
12. Mahl MC, Sadler C. Virus survival on inanimate surfaces. Can J Microbiol. 1975;21:819-823.
13. Nauheim RC, Romanowski EG, Araullo-Cruz T, Kowalski RP, Turgeon PW, Stopak SS, Gordon YJ. Prolonged recoverability of desiccated adenovirus type 19 from various surfaces. Ophthalmology. 1990;97:1450-1453.
14. Huntoon CJ, House RF, Jr., Smith TF. Recovery of viruses from three transport media incorporated into culturelles. Arch Pathol Lab Med. 1981;105:436-437.
15. Johnson FB. Transport of viral specimens. Clin Microbiol Rev. 1990;3:120-131.
16. Leibovitz A. A transport medium for diagnostic virology. Proc Soc Exp Biol Med. 1969;131:127-130.
17. Rutala WA, Shelton DF, Arbiter D. Comparative sensitivities of viruses to cell cultures and transport media. Am J Clin Pathol. 1977;67:397-400.
18. Kowalski RP, Karenchak LM, Romanowski EG, Gordon YJ, Community Ophthalmologists of Pittsburgh, Pennsylvania. Evaluation of the shell vial technique for detection of ocular adenovirus. Ophthalmology. 1999;106:1324-1327.
19. Wilhelmus KR. Interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2003: CD002898.
20. Hoh HB, Hurley C, Claoue C et al. Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study. Br J Ophthalmol. 1996;80:140-143.
21. Kowalski RP, Romanowski EG, Waikhom B, Gordon YJ, The survival of adenovirus in multidose bottles of topical fluorescein. Am J Ophthalmol. 1998;126:835-836.
22. Roba LA, Kowalski RP, Gordon AT, Romanowski EG, Gordon YJ. Adenoviral ocular isolates demonstrate serotype-dependent differences in in vitro infectivity titers and clinical course. Cornea. 1995;14:388-393.
23. Aoki K, Tagawa Y. A twenty-one year surveillance of adenoviral conjunctivitis in Sapporo, Japan. Int Ophthalmol Clin. 2002;42:49-54.
24. Erdman DD, Xu W, Gerber SI, Gray GC, Schnurr D, Kajon AE, Anderson LJ. Molecular epidemiology of adenovirus type 7 in the United States, 1966-2000. Emerg Infect Dis. 2002;8:269-277.
25. Guo DF, Shinagawa M, Aoki K, Sawada H, Itakura S, Sato G. Genome typing of adenovirus strains isolated from conjunctivitis in Japan, Australia, and the Philippines. Microbiol Immunol. 1988;32:1107-1118.
26. Imperiale MJ, Kochanek S. Adenovirus vectors: Biology, design, and production. Curr Top Microbiol Immunol. 2004;273:335-357.
27. Palmer DH, Mautner V, Kerr DJ. Clinical experience with adenovirus in cancer therapy. Curr Opin Mol Ther. 2002;4:423-434.