Synthesis of the 3H-labelled 5-HT3 antagonist (RS-25259-197) at high specific activity

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 38, Issue 5, 1996, Pages 425-433

  Gong, Leyi ^a   Pames, Howard ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

5 HT3 antagonist; anti emetic agent; RS 25259 3H

Indexed keywords

AMIDES;

% REDUCTIONS; 5-HT3 ANTAGONIST; ANTI-EMETIC AGENT; CYCLIZATIONS; HIGH SPECIFIC ACTIVITIES; LABELINGS; PROPERTY; RS-25259-3H; SYNTHESISED; TITLE COMPOUNDS;

CYCLIZATION;

RS 25259197; SEROTONIN ANTAGONIST; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ISOTOPE LABELING;

EID: 9344240450     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199605)38:5<425::AID-JLCR860>3.0.CO;2-B     Document Type: Article

References (6)

1. Kilpatrick, G.J., Bunce, K.T., Tyers, M.B. -Med. Res.Rev. 10: 441 (1990).
2. Tyers, M.B. - Therapie (Paris) 46: 431 (1991).
3. Eglen, R.M., Lee, C.-H., Smith, W.L. et al. -British J. Pharmacology 114:860 (1995).
4. King, F.D., Jones, B.J., Sanger, G.J. 5-Hydroxytryptamine-3 Receptor Antagonists; CRC press: Ann Arbor, p255 (1994).
5. Berger, J., Clark, R.D., Eglen, R.M., Smith, W.L., Weihardt, K.K. US patent, Patent No. 5,202,333, April 13, 1993.
6. Wong, E.H.F., Clark, R., Leung, E., et al -British J. Pharmacology 114: 851 (1995).