Pharmacokinetics and efficacy of low-dose all-trans retinoic acid in the treatment of acute promyelocytic leukemia

Leukemia

Volumn 10, Issue 5, 1996, Pages 825-828

  Chen, G Q ^a   Shen, Z X ^a   Wu, F ^a   Han, J Y ^b   Miao, J M ^b   Zhong, H J ^c   Li, X S ^a   Zhao, J Q ^b   Zhu, J ^a   Fang, Z W ^b   Chen, S J ^a   Chen, Z ^a   Wang, Z Y ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

APL; ATRA; Low dose; Pharmacokinetics

Indexed keywords

CYTARABINE; DAUNORUBICIN; HARRINGTONINE; METHOTREXATE; RETINOIC ACID;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ARTHRALGIA; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG EFFICACY; DRY SKIN; FEMALE; HEADACHE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INFECTION; INTRAMUSCULAR DRUG ADMINISTRATION; LEUKOCYTOSIS; LIVER TOXICITY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RETINOIC ACID SYNDROME;

EID: 9344234374     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Warrell RP Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. New Engl J Med 1993; 329: 177-189.
2. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Nonti E, Biondi A, LoCoco F, Grignani F, Pelieci PC. Acute promyelocytic leukemia: from genetics to treatment. Blood 1994; 83: 10-25.
3. Chen SJ, Wang ZY, Chen Z. Acute promyelocytic leukemia: from clinic to molecular biology. Stem Cells 1995; 13: 1-5.
4. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhao L, Cu LJ, Wang ZY. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72: 567-572.
5. Castaigne S, Chomienne C, Daniel M, Ballerini P, Berger R, Fenaux P, Degos L. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. Blood 1990; 76: 1704-1709.
6. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreff A, Tafudi A, Jakubowski A, Gabrilove J, Gordon M, Dmitrovsky E. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid). New Engl J Med 1991; 324: 1385-1393.
7. Degos L, Dombret H, Chomienne C, Daniel NT, Miclea JM, Chastang C, Castaigne S, Fenaux P. ATRA as a differentiation agent in the treatment of acute promyelocytic leukemia. Blood 1995; 85: 2643-2653.
8. Frankel SR, Eardley A, Lauwers C, Weiss M, Warrell RP Jr. The retinoic acid syndrome in acute promyelocytic leukemia. Ann Intern Med 1992; 117: 292-296.
9. Warrell RP Jr. Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies and implications. Blood 1993; 82: 1949-1953.
10. Wang ZY, Chen Z, Huang ME, Li XS, Lu XS, Huang LA. Problems existing in differentiation therapy of acute promyelocytic leukemia with all-trans retinoic acid. Blood Cells 1993; 19: 633-639.
11. Muindi JRF, Frankel S, Huselton C, DeGrazia F, Garland W, Young CW, Warrell RP Jr. Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia. Cancer Res 1992; 52: 2138-2142.
12. Delva L, Cornic M, Balitrand N, Guidez F, Miclea JM, Delmer A, Teillet F, Fenaux P, Castaigne S, Degos L, Chomienne C. Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: study of in vitro all-trans retinoic acid sensitivity and cellular retinoic acid-binding protein levels in leukemic cell. Blood 1993; 82, 2175-2181.
13. Chomienne C, Ballerni P, Balitrand N, Daniel MT, Fenaux P, Castaigne S, Degos L. All-trans retinoic acid in acute promyelocytic leukemia. II. in vitro result: structure-function relationship. Blood 1990; 76: 1710-1717.
14. de The H, Lavau C, Marehio A, Chomienne C, Degos L, Dejean A. The PML-RARa fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991; 66: 675-684.
15. 2) in acute promyelocytic leukemia. Blood 1993; 82: 3560-3563.
16. Huang W, Sun GL, Li XS, Cao Q, Lu Y, Jang GS, Zhang FQ, Chai JR, Wang ZY, Waxman S, Chen Z, Chen SJ. Acute promyelocytic leukemia: clinical relevance of two major PML-RARa isoforms and detection of minimal residual disease by RT-PCR to predict relapse. Blood 1993; 82: 1264-1269.
17. Vane FM, Stoltenborg JK, Bugge JL. Determination of 13-cis retinoic acid and its major metabolite, 4-oxo-13-cis retinoic acid in human blood by reverse-phase HPLC. J Chromatgr 1982; 227: 471-479.
18. Lefebvre P, Thomas G, Gourmei B, Agadir A, Castaigne S, Dreux C, Degos L, Chomienne C. Pharmacokinetics of oral all-trans retinoic acid in patients with acute promyelocytic leukemia. Leukemia 1991; 5: 1054-1058.
19. Sun GL, OuYang RR, Chen SJ, Gu LJ, Xie WY, Zhang FQ, Li XS, Zhong DH, Cai JR, Chen Z, Wang ZY, Lu JX, Huang LA, Qian ZC, Yu HQ, Wang YL. Treatment of APL with all-trans retinoic acid: a report of five-year experience. Chin J Cancer 1993; 11: 125-128.
20. Li YP, Said F, Gallagher RE. Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-α. Blood 1994; 83: 3298-3302.
21. Robertson KA, Emami B, Collins SJ. Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood 1992; 80: 1885-1889.
22. Dermime S, Grignani F, Clerici M, Nervi C, Sozzi G, Talamo GP, Marchesi E, Formelli F, Parmiani G, Pelici PG, Gambacorti-Passerini C. Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RARa protein. Blood 1993; 82: 1573-1577.
23. Muindi JRF, Frankel SR, Miller WH, Jakubowski A, Scheinberg DA, Young CW, Dmitrosky E, Warrell RP Jr. Continuous treatment with all-trans retinoic acid results in a progressive decrease in plasma concentrations: implications for relapse and retinoid 'resistance' in acute promyelocytic leukemia. Blood 1992; 79: 299-303.
24. Qie XQ, Miao JM, Fang ZW, Shou NX, Zhao JQ, Man JY, OuYang RR. Clinical pharmacokinetics of all-trans retinoic acid. Chin J Hematol 1994; 15: 70-72.