Efficacy of antiviral agents in feline herpetic keratitis: Results of an in vitro study

Current Eye Research

Volumn 29, Issue 2-3, 2004, Pages 215-218

  Williams, D L ^a   Fitzmaurice, T ^a   Lay, L ^a   Forster, K ^a   Hefford, J ^a   Budge, C ^a   Blackmore, K ^a   Robinson, J C ^a   Field, H F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Acyclovir; Antiviral; Cat; Cornea; Feline; Herpes virus; Treatment

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; ACICLOVIR; ANTIVIRUS AGENT; PENCICLOVIR; TRIFLURIDINE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; CAT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DOSE; DRUG EFFICACY; EMBRYO; FELINE HERPES SIMPLEX VIRUS 1; FELINE HERPETIC KERATITIS; HERPES SIMPLEX KERATITIS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS PLAQUE; VIRUS STRAIN;

ACYCLOVIR; ADENINE; ANIMALS; ANTIVIRAL AGENTS; BROMODEOXYURIDINE; CAT DISEASES; CATS; CELLS, CULTURED; KERATITIS, HERPETIC; PHOSPHONIC ACIDS; PLAQUE ASSAY; TRIFLURIDINE;

EID: 9344230408     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680490504849     Document Type: Conference Paper

References (14)

1. Williams D, Robinson JC, Lay E, Field HJ. Efficacy of topical acyclovir in feline herpetic keratitis: Results of a prospective clinical trial together with data from in vitro investigations. Vet Rec. 2003 (in press).
2. Andrew SE. Ocular manifestations of feline herpesvirus. J Feline Med Surg. 2001;3:9-16.
3. Nasisse MP, Guy JS, Davidson MG, Sussman W, De Clercq E. In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyl-deoxyuridine. Am J Vet Res. 1989 50:158-160.
4. Collins P. The spectrum of antiviral activities of acyclovir in vitro and in vivo. J Antimicrob Chemother. 1983;12 (Suppl B):19-27.
5. Rollinson EA. Prospects for the development of antiviral agents for veterinary use. In: Field HJ, editor. Antiviral agents: The Development and Assessment of Antiviral Chemotherapy. Boca Raton, FL: CRC Press, 1983;11: 85-117.
6. Hirschberger J. Use of acyclovir (antiviral agent) in cats. Tierarztliche Praxis 1983;16:427-430.
7. Nasisse MP, Guy JS. Feline ocular disease and rhinotracheitis virus. Vet Med Rep. 1989;1:155-165.
8. De Clercq E. In search of a selective antiviral chemotherapy. Clin Microbiol Rev. 1997;10:674-693.
9. Chibo D, Druce J, Sasadeusz J, Birch C. Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus. Antiviral Res. 2004;61:83-91.
10. Yokoyama N, Maeda K, Tohya Y, Kawaguchi Y, Shin YS, Ono M, Ishiguro S, Fujikawa Y, Mikami T. Pathogenicity and vaccine efficacy of a thymidine kinase-deficient mutant of feline herpesvirus type 1 in cats. Arch Virol. 1996;141:481-494.
11. Nunberg JH, Wright DK, Cole GE, Petrovskis EA, Post LE, Compton T, Gilbert JH. Identification of the thymidine kinase gene of feline herpesvirus: Use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs. J Virol. 1989;63:3240-3249.
12. De Clercq E. The antiviral spectrum of (E)-5-(2-bromovinyl)-2′- deoxyuridine. J Antimicrob Chemother. 1984;14(Suppl A):85-95.
13. De Clercq E, Descamps J, De Somer P, Holy A. (S)-9-(2,3-Dihydroxypropyl) adenine: An aliphatic nucleoside analog with broad-spectrum antiviral activity. Science. 1978;200:563-565.
14. Oberg B. Antiviral effects of phosphonoformate (PFA, fos-carnet sodium). Pharmacol Ther. 1989;40(2):213-285.