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Volumn 49, Issue 5, 1996, Pages 874-881

Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; BETA NAPHTHOFLAVONE; CYTOCHROME P450; PHOSPHORUS 32;

EID: 9244259054     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (40)
  • 1
    • 0028764656 scopus 로고
    • Heterocyclic amines in cooked foods: Candidates for causation of common cancers
    • Sugimura, T., M. Nagao, and K. Wakabayashi. Heterocyclic amines in cooked foods: candidates for causation of common cancers. J. Natl. Cancer Inst. 86:2-4 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 2-4
    • Sugimura, T.1    Nagao, M.2    Wakabayashi, K.3
  • 2
    • 0024492347 scopus 로고
    • Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in food
    • Snyderwine, E. G., and Battula, N. Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in food. J. Natl. Cancer Inst. 81:223-227 (1989).
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 223-227
    • Snyderwine, E.G.1    Battula, N.2
  • 3
    • 0022566931 scopus 로고
    • Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates
    • Kato, R. Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates. CRC Crit. Rev. Toxicol. 16:307-348 (1986).
    • (1986) CRC Crit. Rev. Toxicol. , vol.16 , pp. 307-348
    • Kato, R.1
  • 4
    • 0023883437 scopus 로고
    • Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA: Synthesis and identification of N-(deoxyguanosine-8-yl)-IQ
    • Snyderwine, E. G., P. P. Roller, R. H. Adamson, S. Sato, and S. S. Thorgeirsson. Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA: synthesis and identification of N-(deoxyguanosine-8-yl)-IQ. Carcinogenesis 9:1061-1065 (1988).
    • (1988) Carcinogenesis , vol.9 , pp. 1061-1065
    • Snyderwine, E.G.1    Roller, P.P.2    Adamson, R.H.3    Sato, S.4    Thorgeirsson, S.S.5
  • 5
    • 0027369714 scopus 로고
    • Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats
    • Davis, C. D., H. A. J. Schut, and E. G. Snyderwine. Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats. Carcinogenesis 14:2091-2096 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 2091-2096
    • Davis, C.D.1    Schut, H.A.J.2    Snyderwine, E.G.3
  • 6
    • 0024320001 scopus 로고
    • Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats
    • Luks, H. J., T. E. Spratt, M. T. Vavrek, S. F. Roland, and J. H. Weisburger. Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Cancer Res. 49:4407-4411 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4407-4411
    • Luks, H.J.1    Spratt, T.E.2    Vavrek, M.T.3    Roland, S.F.4    Weisburger, J.H.5
  • 7
    • 0027078564 scopus 로고
    • Metabolism of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in non-human primates undergoing carcinogen bioassay
    • Snyderwine, E. G, D. H. Welti, L. B. Fay, H. P. Wurzner, and R. J. Turesky. Metabolism of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in non-human primates undergoing carcinogen bioassay. Chem. Res. Toxicol. 5:843-351 (1992).
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 843-1351
    • Snyderwine, E.G.1    Welti, D.H.2    Fay, L.B.3    Wurzner, H.P.4    Turesky, R.J.5
  • 8
    • 0027944549 scopus 로고
    • Analysis of the four alleles of the murine aryl hydrocarbon receptor
    • Poland, A., D. Palen, and E. Glover. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 46:915-921 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 915-921
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 10
    • 0027429540 scopus 로고
    • Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease
    • Gonzalez, F. J., and H. V. Gelboin. Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease. J. Toxicol. Environ. Health 40:289-308 (1993).
    • (1993) J. Toxicol. Environ. Health , vol.40 , pp. 289-308
    • Gonzalez, F.J.1    Gelboin, H.V.2
  • 12
    • 0027477877 scopus 로고
    • Metabolic activation of N-hydroxy-2-aminofluoreoe and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus
    • Hein, D. W., M. A. Doll, K. Gray, T. D. Rustan, and R. J. Ferguson. Metabolic activation of N-hydroxy-2-aminofluoreoe and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus. Cancer Res. 53:509-514 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 509-514
    • Hein, D.W.1    Doll, M.A.2    Gray, K.3    Rustan, T.D.4    Ferguson, R.J.5
  • 13
    • 0025952469 scopus 로고
    • Molecular genetic basis of rapid and slow acetylation in mice
    • Martell, K. J., K. P. Vatsis, and W. W. Weber. Molecular genetic basis of rapid and slow acetylation in mice. Mol. Pharmacol. 40:218-237 (1991).
    • (1991) Mol. Pharmacol. , vol.40 , pp. 218-237
    • Martell, K.J.1    Vatsis, K.P.2    Weber, W.W.3
  • 15
    • 0027369267 scopus 로고
    • Role of acetylation in colorectal cancer
    • Minchin, R. F., F. F. Kadlubar, and K F. Ilett. Role of acetylation in colorectal cancer. Mutat. Res. 290:35-42 (1993).
    • (1993) Mutat. Res. , vol.290 , pp. 35-42
    • Minchin, R.F.1    Kadlubar, F.F.2    Ilett, K.F.3
  • 16
    • 0027999623 scopus 로고
    • Rapid metabolic phenotypes for acetyltransferases and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps
    • Lang, N. P., M. A. Butler, J. Massengill, M. Lawson, R. C. Stotts, M. Hauer-Jensen, and F. F. Kadlubar. Rapid metabolic phenotypes for acetyltransferases and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol. Biomarkers Prevent. 3:675-682 (1994).
    • (1994) Cancer Epidemiol. Biomarkers Prevent. , vol.3 , pp. 675-682
    • Lang, N.P.1    Butler, M.A.2    Massengill, J.3    Lawson, M.4    Stotts, R.C.5    Hauer-Jensen, M.6    Kadlubar, F.F.7
  • 17
    • 0026701773 scopus 로고
    • The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
    • Probst, M. R., M. Blum, I. Fasshauer, D. D'Orazio, U. A. Meyer, and D. Wild. The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Carcinogenesis 13:1713-1717 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1713-1717
    • Probst, M.R.1    Blum, M.2    Fasshauer, I.3    D'Orazio, D.4    Meyer, U.A.5    Wild, D.6
  • 18
    • 0028306041 scopus 로고
    • Relation between the occurrence of K-nzs gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas
    • Oda, Y., M. Tanaka, and I. Nakanishi. Relation between the occurrence of K-nzs gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas. Carcinogenesis 15:1366-1369 (1994).
    • (1994) Carcinogenesis , vol.15 , pp. 1366-1369
    • Oda, Y.1    Tanaka, M.2    Nakanishi, I.3
  • 19
    • 0029013510 scopus 로고
    • DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder and kidney of congenic mice differing in Ah-responsiveness and N-acetyltransferase genotype
    • Nerurkar, P. V., H. A. J. Schut, L. M. Anderson, C. W. Riggs, E. G. Snyderwine, S. S. Thorgeirsson, W. W. Weber, J. M. Rice, and G. N. Levy. DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder and kidney of congenic mice differing in Ah-responsiveness and N-acetyltransferase genotype. Cancer Res. 55:3043-3049 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 3043-3049
    • Nerurkar, P.V.1    Schut, H.A.J.2    Anderson, L.M.3    Riggs, C.W.4    Snyderwine, E.G.5    Thorgeirsson, S.S.6    Weber, W.W.7    Rice, J.M.8    Levy, G.N.9
  • 21
    • 0024119530 scopus 로고
    • Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase
    • Mattano, S. S., R. P. Erickson, M. N. Nesbitt, and W. W. Weber. Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase. J. Hered. 79:430-433 (1988)
    • (1988) J. Hered. , vol.79 , pp. 430-433
    • Mattano, S.S.1    Erickson, R.P.2    Nesbitt, M.N.3    Weber, W.W.4
  • 22
    • 0025347724 scopus 로고
    • 2-Aminofluorene-hepatic DNA adducts in congenic mouse lines differing in the Ah responsiveness
    • Levy, G. N., and W. W. Weber. 2-Aminofluorene-hepatic DNA adducts in congenic mouse lines differing in the Ah responsiveness. Carcinogenesis 11:1233-1235 (1990).
    • (1990) Carcinogenesis , vol.11 , pp. 1233-1235
    • Levy, G.N.1    Weber, W.W.2
  • 23
    • 0022357068 scopus 로고
    • Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
    • Burke, M. D., S. Thompson, C. R. Eicombe, J. Halpert, T. Haaparanta, and R. T. Mayer. Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34:3337-3345 (1985)
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Eicombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Mayer, R.T.6
  • 24
    • 0027179679 scopus 로고
    • Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse
    • Nerurkar, P. V., S. S. Park, P. E. Thomas, R. W. Nims, and R. A. Lubet. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmaeol. 46:933-943 (1993).
    • (1993) Biochem. Pharmaeol. , vol.46 , pp. 933-943
    • Nerurkar, P.V.1    Park, S.S.2    Thomas, P.E.3    Nims, R.W.4    Lubet, R.A.5
  • 26
    • 0020071879 scopus 로고
    • Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450
    • Park, S. S., T. Fujino, D. West, F. P. Guengerich, and H. V. Gelboin. Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450. Cancer Res. 42:1798-1808 (1982).
    • (1982) Cancer Res. , vol.42 , pp. 1798-1808
    • Park, S.S.1    Fujino, T.2    West, D.3    Guengerich, F.P.4    Gelboin, H.V.5
  • 27
    • 0027163025 scopus 로고
    • Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: Low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo
    • Davis, C. D., H. A. J. Schut, R. H. Adamson, U. P. Thorgeirsson, S. S. Thorgeirsson, and E. G. Snyderwine. Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo. Carcinogenesis 14:61-65 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 61-65
    • Davis, C.D.1    Schut, H.A.J.2    Adamson, R.H.3    Thorgeirsson, U.P.4    Thorgeirsson, S.S.5    Snyderwine, E.G.6
  • 28
    • 0023749970 scopus 로고
    • DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in target tissues of the F-344 rat
    • Schut, H. A. J., K. L. Putman, and K. Randerath. DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in target tissues of the F-344 rat. Cancer Lett. 41:345-352 (1988).
    • (1988) Cancer Lett. , vol.41 , pp. 345-352
    • Schut, H.A.J.1    Putman, K.L.2    Randerath, K.3
  • 29
    • 0028785833 scopus 로고
    • Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in male CDF1 mice
    • Cummings, D. A., and H. A. J. Schut. Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in male CDF1 mice. Carcinogenesis 16: 2523-2529 (1995).
    • (1995) Carcinogenesis , vol.16 , pp. 2523-2529
    • Cummings, D.A.1    Schut, H.A.J.2
  • 30
    • 0024847231 scopus 로고
    • Effect of enzyme inducers on the metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) in the rat
    • Vavrek, M. T., P. Sodoti, J. Reinhardt, and J. H. Weisburger. Effect of enzyme inducers on the metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) in the rat. Cancer Lett. 48:183-188 (1989).
    • (1989) Cancer Lett. , vol.48 , pp. 183-188
    • Vavrek, M.T.1    Sodoti, P.2    Reinhardt, J.3    Weisburger, J.H.4
  • 31
    • 0027213292 scopus 로고
    • Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in F344 rats
    • Snyderwine E. G., K. Nouso, and H. A. J. Schut. Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in F344 rats. Food Chem. Toxicol. 31: 415-423 (1993).
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 415-423
    • Snyderwine, E.G.1    Nouso, K.2    Schut, H.A.J.3
  • 32
    • 0024440761 scopus 로고
    • Characterization of metabolites of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline formed after incubation with isolated rat liver cells
    • Alexander, J., J. A. Holme, H. Wallin, and G. Becher. Characterization of metabolites of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline formed after incubation with isolated rat liver cells. Chem. Biol. Interact. 72:125-142 (1989).
    • (1989) Chem. Biol. Interact. , vol.72 , pp. 125-142
    • Alexander, J.1    Holme, J.A.2    Wallin, H.3    Becher, G.4
  • 33
    • 0025044195 scopus 로고
    • Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines
    • Neumann, H.-G., R. Hammerl, W. Hillesheim, and M. Wildschutte. Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines Environ. Health Perspect. 88:207-211 (1990).
    • (1990) Environ. Health Perspect. , vol.88 , pp. 207-211
    • Neumann, H.-G.1    Hammerl, R.2    Hillesheim, W.3    Wildschutte, M.4
  • 34
    • 0026693657 scopus 로고
    • In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines
    • Kleman, M. I., E. Overvik, G. G. F. Mason, and J. Gustafsson. In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines. Carcinogenesis 13:1619-1624 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1619-1624
    • Kleman, M.I.1    Overvik, E.2    Mason, G.G.F.3    Gustafsson, J.4
  • 36
    • 0027422214 scopus 로고
    • Cytoehrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines
    • Hellmold, H., E. Overvik, M. Stromstedt, and J.-A. Gustafsson. Cytoehrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines. Carcinogenesis 14:1751-1757 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 1751-1757
    • Hellmold, H.1    Overvik, E.2    Stromstedt, M.3    Gustafsson, J.-A.4
  • 37
    • 0028179794 scopus 로고
    • 32P-post-labeling analysis of DNA adducts formed by food-derived heterocyclic amines: Evidence for incomplete hydrolysis and a procedure for adduct pattern simplification
    • 32P-post-labeling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct pattern simplification. Carcinogenesis 15:877-882 (1994).
    • (1994) Carcinogenesis , vol.15 , pp. 877-882
    • Pfau, W.1    Brockstedt, U.2    Sohren, K.3    Marquardt, H.4
  • 38
    • 0026003132 scopus 로고
    • Sex differences in the formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice
    • Zu, H.-X., and H. A. J. Schut. Sex differences in the formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice. Carcinogenesis 12:2163-2168 (1991).
    • (1991) Carcinogenesis , vol.12 , pp. 2163-2168
    • Zu, H.-X.1    Schut, H.A.J.2
  • 39
    • 0025279658 scopus 로고
    • Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ)
    • Hall, M., M. N. She, D. Wild, I. Fasshauer, A. Hewer, and D. H. Phillips. Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). Carcinogenesis 11:1005-1011 (1990).
    • (1990) Carcinogenesis , vol.11 , pp. 1005-1011
    • Hall, M.1    She, M.N.2    Wild, D.3    Fasshauer, I.4    Hewer, A.5    Phillips, D.H.6


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