Extremely low frequency-modulated static magnetic fields to treat cancer: A pilot study on patients with advanced neoplasm to assess safety and acute toxicity

Bioelectromagnetics

Volumn 25, Issue 8, 2004, Pages 563-571

  Ronchetto, Flavio ^a,e   Barone, Domenico ^b   Cintorino, Marcella ^c   Berardelli, Michele ^d   Lissolo, Silvana ^a   Orlassino, Renzo ^d   Ossola, Piero ^d   Tofani, Santi ^d  

^a Div of Med and Geriatric Oncology   (Italy)

^b Biomed Research Institute A Marxer   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d Service of Oncology ASL 9 Ivrea   (Italy)

^e Ivrea Cuorgnè ASL9 Hospital   (Italy)

Author keywords

Cancer; ELF field; Pilot study; Safety; Static field; Toxicity

Indexed keywords

AMINO ACIDS; BLOOD; DISEASES; FREQUENCY MODULATION; MAGNETIC FIELDS; PATIENT TREATMENT;

ACUTE TOXICITY; CANCER; ELF FIELD; EXTREMELY LOW FREQUENCIES; FREQUENCY MODULATED; HUMAN STUDY; MAGNETIC-FIELD; PILOT STUDIES; STATIC FIELDS; STATIC MAGNETIC FIELDS;

TOXICITY;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE;

ABDOMEN; ADULT; ADVANCED CANCER; AGED; ARTICLE; CLINICAL ARTICLE; DIARRHEA; DYSPNEA; ECOG PERFORMANCE STATUS; ELECTROCARDIOGRAPHY; EXPOSURE; EXTREMELY LOW FREQUENCY MODULATED STATIC MAGNETIC FIELD; FEMALE; FREQUENCY MODULATION; FUNCTIONAL ASSESSMENT; HEART ATRIUM ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEMATURIA; HUMAN; INFECTION; LIVER TOXICITY; LUNG EDEMA; MAGNETIC FIELD; MALE; MOTOR DYSFUNCTION; NAUSEA AND VOMITING; NECK; PARESTHESIA; PHYSICAL EXAMINATION; PILOT STUDY; PRIORITY JOURNAL; PROFESSIONAL STANDARD; PROTEINURIA; SAFETY; THORAX; THORAX RADIOGRAPHY; TOXICITY;

EID: 9244247652     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/bem.20029     Document Type: Article

References (19)

1. Basset CA, Mitchell SN, Gaston SR. 1982. Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses. JAMA 247(5):623-628.
2. De Seze R, Tuffet S, Moreau JM, Veyret B. 2000. Effects of 100 mT time varying magnetic fields on the growth of tumors in mice. Bioelectromagnetics 21:107-111.
3. Dibirdik I, Kristupaitis D, Kurosaki T, et al. 1998. Stimulation of Src family Protein-tirosine Kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields. J Biol Chem 273:4035-4039.
4. Gray JR, Frith CH, Parker JD. 2000. In vivo enhancement of chemotherapy with static electronic or magnetic fields. Bioelectromagnetics 21:575-583.
5. Heende WR, Boteler JC. 1994. The question of health effects from exposure to electromagnetic fields. Health Phys 66:127-136.
6. Hisamitsu T, Narita K, Kasahara T, et al. 1997. Induction of apoptosis in human leukemic cells by magnetics fields. Jpn J Physiol 47:307-310.
7. Koifman S. 1993. Electromagnetic fields: A cancer promoter? Med Hypothesis 41:23-27.
8. Kristupaitis D, Dibirdik I, Vassilev A, et al. 1998. Electromagnetic field-induced stimulation of Bruton's tyrosine kinase. J Biol Chem 273:12397-12401.
9. NIEHS, National Institute of Environmental Health Sciences. 1999. NIEHS report on health effects from exposure to power-line frequency electric and magnetic fields. NIH Publication No 99-4493.
10. NRC, National Research Council. 1996. Committee on the possible effects of electromagnetic fields on biologic systems. Possible health effects of exposure to residential electric and magnetic fields. Washington: National Academy Press.
11. Salvatore JR, Harrington J, Kummet T. 2003. Phase I clinical study of a static magnetic field combined with anti-neoplastic chemotherapy in the treatment of human malignancy: Initial safety and toxicity data. Bioelectromagnetics 24:524-527.
12. Simko M, Kriehuber R, Weiss DG, Luben RA. 1998. Effects of 50 Hz EMF exposure on micronucleous formation and apoptosis in trasformed and nontrasformed human cell lines. Bioelectromagnetics 19:85-91.
13. Tofani S. 1999a. Physics may help chemistry to improve medicine: A possible mechanisms for anticancer activity of static and ELF magnetic fields. Physica Medica 15:291-294.
14. Tofani S, Barone D, Cintorino M, et al. 1999b. Tumor growth inhibition, apoptosis and loss of p53 expression induced in vitro and in vivo by magnetic fields [Abstract 3225]. Proc Am Assoc Cancer Res 40:488.
15. Tofani S, Barone D, Cintorino M, et al. 2001a. Static and ELF magnetic fields induce tumor growth inhibition and apoptosis. Bioelectromagnetis 22(6):419-428.
16. Tofani S, Cintorino M, Barone D, et al. 2001b. Evidences for anticancer activity on primary or metastatic cancer by nonthermal magnetic fields. Int J Mol Med 8(Suppl 1):S90.
17. Tofani S, Cintorino M, Barone D, et al. 2002a. Increased mouse survival, tumor growth inhibition and decreased immunorective p53 after exposure to magnetic fields. Bioelectromagnetics 23(3):234-242.
18. Tofani S, Barone D, Peano S, Ossola P, Ronchetto F, Cintorino M. 2002b. Anticancer activity by non-thermal magnetic fields: inhibition of metastatic spread and growth in a breast cancer model. IEEE Plasma Science 30(4):1552-1557.
19. Tofani S, Barone D, Berardelli M, Berno E, Cintorino M, Foglia L, Ossola P, Ronchetto F, Toso E, Eandi M. 2003. Static and ELF magnetic fields enhance the in vivo anti-tumor efficacy of cisplatin against Lewis lung carcinoma, but not of Cyclophosphamide against B16 melanotic melanoma. Pharmacol Res 48(1):83-90.