Gene therapy-mediated CD40L and CD28 co-stimulatory signaling blockade plus transient anti-xenograft antibody suppression induces long-term acceptance of cardiac xenografts

Transplantation

Volumn 78, Issue 10, 2004, Pages 1463-1470

  Hua, Nan ^a   Yamashita, Kenichiro ^a   Hashimoto, Taku ^a   Masunaga, Taro ^b   Fujita, Miri ^c   Furukawa, Hiroyouki ^a   Uede, Toshimitsu ^b   Todo, Satoru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c Shinnittetsu Muroran General Hospital   (Japan)

Author keywords

Adenovirus; Blockade; Co stimulation; Concordant; FK779; Gene therapy; Xenotransplantation

Indexed keywords

2 CYANO N (4 CYANOPHENYL) 3 CYCLOPROPYL 3 HYDROXYPROPENOIC ACID AMIDE; ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FK 779; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT; ISOXAZOLE DERIVATIVE; T LYMPHOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; GENE THERAPY; GRAFT PRESERVATION; GRAFT REJECTION; GRAFT SURVIVAL; HAMSTER; HEART GRAFT; HEART TRANSPLANTATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; LONG TERM CARE; MACROPHAGE; MALE; MICROSCOPY; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; XENOGRAFT;

ANIMALS; ANTIBODIES, HETEROPHILE; ANTIGENS, CD28; BETA-GALACTOSIDASE; CD40 LIGAND; CRICETINAE; GENE THERAPY; GENETIC VECTORS; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOCONJUGATES; LIVER; MALE; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 9244242016     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000144324.83846.A9     Document Type: Article

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