Behavioral and neurochemical effects of the intrahippocampal co-injection of β-amyloid protein1-40 and ibotenic acid in rats

International Journal of Neuroscience

Volumn 114, Issue 12, 2004, Pages 1521-1531

  Li, Ya ^a   Qin, Hai Qiang ^b   Chen, Qi Sheng ^b   Wang, Jian Jun ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

amyloid protein1 40; Ibotenic acid; Learning and memory; Malondialdehyde; Membrane fluidity; Superoxide dismutase

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; AMYLOID BETA PROTEIN[1-42]; IBOTENIC ACID; SUPEROXIDE DISMUTASE;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; MEMBRANE FLUIDITY; MEMORY; MEMORY DISORDER; MENTAL TASK; MITOCHONDRION; NEUROCHEMISTRY; NONHUMAN; OPEN FIELD BEHAVIOR; PASSIVE AVOIDANCE; PEROXIDATION; RAT; STATISTICAL SIGNIFICANCE; TASK PERFORMANCE;

AMYLOID BETA-PROTEIN; ANIMALS; AVOIDANCE LEARNING; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; IBOTENIC ACID; LEARNING DISORDERS; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMBRANE FLUIDITY; MEMORY DISORDERS; MITOCHONDRIA; PEPTIDE FRAGMENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 9244234423     PISSN: 00207454     EISSN: None     Source Type: Journal    
DOI: 10.1080/00207450490509159     Document Type: Article

References (22)

1. Cleary, J., Hittner, J. M., Semotuk, M., Mantyh, P., & O'Hare, E. (1995). Beta-amyloid (1-40) effects on behavior and memory. Brain Research, 682, 69-74.
2. Eckert, G. P., Wood, W. G., & Muller, W. E. (2001). Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranes. Journal of Neural Transmission, 108, 1051-1064.
3. Games, D., Khan, K. M., Soriano, F. G., Keim, P. S., Davis, D. L., Bryant, T. K., & Lieberburg, I. (1992). Lack of Alzheimer pathology after β-amyloid protein injections in rat brain. Neurobiology of Aging, 13, 569-576.
4. Hyman, B. T., Marzloff, K., & Arriagada, P. V. (1993). The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. Journal of Neuropathology and Experimental Neurology, 52, 594-600.
5. Kowall, N. W., Beal, M. F., Busciglio, J., Duffy, L. K., & Yankner, B. A. (1991). An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P. Proceedings of the National Academy of Sciences of USA, 88, 7247-7251.
6. Kowall, N. W., McKee, A. C., Yankner, B. A., & Beal, M. F. (1992). In vivo neurotoxicity of beta-amyloid β (1-40)] and the β (25-35) fragment. Neurobiology of Aging, 13, 537-542.
7. Levin, E. D., Christopher, N. C., Weaver, T., Moore, J., & Brucato, F. (1999). Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. Cognitive Brain Research, 7, 405-410.
8. Liu, P., & Bilkey, D. K. (2001). The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks. Behavioral Neuroscience, 115, 94-111.
9. Lowry, O., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein determination with the phenol reagent. The Journal of Biological Chemistry, 193, 265-275.
10. Markesbery, W. R. (1997). Oxidative stress hypothesis in Alzheimer's disease. Free Radical Biology & Medicine, 23, 134-147.
11. May, P. C., Gitter, B. D., Waters, D. C., Simmons, L. K., Becker, G. W., Small, J. S., & Robison, P. M. (1992). Beta-amyloid peptide in vitro toxicity: Lot to lot variability. Neurobiology of Aging, 13, 605-607.
12. McDonal, M. P., Dahl, E. E., Overmier, J. B., Mantyh, P., & Cleary, J. (1994). Effects of an exogenous beta-amyloid peptide on retention for spatial learning. Behavioral and Neural Biology, 62, 60-67.
13. Mecocci, P., Cherubini, A., Beal, M. F., Cecchetti, R., Chionne, F., Polidori, M. C., & Romano, G. (1996). Altered mitochondrial membrane fluidity in AD brain. Neuroscience Letters, 207, 129-132.
14. Morimoto, K., Yoshimi, K., Tonohiro, T., Yamada, N., Oda, T., & Kaneko, I. (1998). Co-injection of β-Amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons. Neuroscience, 84, 479-487.
15. Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissue bythiobarbituric acid reaction. Analytical Biochemistry, 95, 351-358.
16. Omar, R. A., Chyan, Y. J., Andorn, A. C., Poeggeler B., Robakis, N. K., & Pappolla, M. A. (1999). Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease. Journal of Alzheimer's Disease, 1, 139-145.
17. Paxinos, G., & Watson, C. (1986). The rat brain in stereotaxic coordinates (2nd ed.). Sydney, Australia: Academic Press, pp. 31-32.
18. Pike, C. J., Walencewicz, A. J., Glabe, C. G., & Cotman, C. W. (1991). Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures. European Journal of Pharmacology, 207, 367-368.
19. Sciamanna, M. A., Zinkel, J., Fabi, A. Y., & Lee, C. P. (1992). Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis. Biochimica et Biophysica Acta, 1134, 223-232.
20. Shinitzy, M., & Barenholz, Y. (1978). Fluidity parameters of lipids regions determined by fluorescence polarization. Biochimica et Biophysica Acta, 515, 367-394.
21. Waschuk, S. A., Elton, E. A., Darabie, A. A., Fraser, P. E., & McLaurin, J. A. (2001). Cellular membrane composition defines A beta-lipid interactions. The Journal of Biological Chemistry, 276, 33561-33568.
22. Zhou, G. L., Gui, X. F., Zhong, X. L., & Zhu, X. F. (1986). A method of measuring SOD activity: A modification of the pyrogallicacid auto-oxidation method. Progress Biochemistry and Biophysics, 13, 71-73.