Finding the maximum safe dose level for heteroscedastic data

Journal of Biopharmaceutical Statistics

Volumn 14, Issue 4, 2004, Pages 843-856

  Tamhane, Ajit C ^a   Logan, Brent R ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Dose response; Multiple comparisons; Toxicology; Unequal variances

Indexed keywords

ANALYTICAL ERROR; CALCULATION; COMPARATIVE TOXICOLOGY; DATA ANALYSIS; DOSE RESPONSE; FAMILY; MAXIMUM PERMISSIBLE DOSE; MONTE CARLO METHOD; PRIORITY JOURNAL; REVIEW; SAFETY; SIMULATION; TOXICOLOGY; VARIANCE;

ALGORITHMS; ANIMALS; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MONTE CARLO METHOD; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 9244227065     PISSN: 10543406     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIP-200035413     Document Type: Review

References (5)

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3. Genz, A., Bretz, F. (1999). Numerical computation of multivariate t-probabilities with application to power calculation of multiple contrasts. J. Statist. Comput. Simul. 63:361-378.
4. Hochberg, Y., Tamhane, A. C. (1987). Multiple Comparison Procedures. New York: Wiley.
5. Tamhane, A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96: 835-843.