Protein Z: "Light and shade" of a new thrombotic factor

Clinical Laboratory

Volumn 50, Issue 11-12, 2004, Pages 647-652

  Sofi, Francesco ^a,b   Cesari, Francesca ^a,b   Fedi, Sandra ^a,b   Abbate, Rosanna ^a,b   Gensini, Gian Franco ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

Coagulation factors; Protein Z; Protein Z dependent protease inhibitor; Thrombosis; Vascular diseases

Indexed keywords

ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING INHIBITOR; FATTY ACID BINDING PROTEIN; PLASMA PROTEIN; PROTEIN C; PROTEINASE INHIBITOR; SERINE PROTEINASE; VITAMIN K GROUP;

AMINO ACID SEQUENCE; ANTIPHOSPHOLIPID SYNDROME; BEHCET DISEASE; BLEEDING TENDENCY; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; COMPLEX FORMATION; DEEP VEIN THROMBOSIS; HEART ATRIUM FIBRILLATION; HEART MUSCLE ISCHEMIA; HEMODIALYSIS PATIENT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY DISEASE; ISCHEMIC COLITIS; NEPHROTIC SYNDROME; PREGNANCY COMPLICATION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REVIEW; SEQUENCE HOMOLOGY; SPONTANEOUS ABORTION; THROMBOEMBOLISM; THROMBOSIS; VASCULAR DISEASE;

ANTIPHOSPHOLIPID SYNDROME; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BLOOD PROTEINS; CEREBROVASCULAR ACCIDENT; CORONARY DISEASE; FACTOR XA; FEMALE; HEMORRHAGE; HUMANS; MODELS, BIOLOGICAL; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS; SERPINS; THROMBOSIS;

EID: 9244226461     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Prowse CV, Esnouf MP. The isolation of a new warfarin-sensitive protein from bovine plasma. Biochem Soc Trans 1977; 5: 255-6.
2. Broze GJ Jr, Miletich JP. Human protein Z. J Clin Invest 1984; 73: 933-8.
3. Hojrup P, Jensen MS, Petersen TE. Amino acid sequence of bovine protein Z: a vitamin K-dependent serine protease homolog. FEBS Lett.1985; 184: 333-8.
4. Ichinose A, Takeya H, Espling E, Iwanaga, S, Kisiel W, Davie EW. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. Biochem Biophys Res Commun 1990; 172: 1139-44.
5. Miletich JP, Broze GJ Jr. Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy. Blood 1987; 69: 1580-6.
6. Fujimaki K, Yamazaki T, Taniwaki M, Ichinose A. The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon. Biochemistry 1998; 37: 6838-46.
7. Hogg PJ, Stenflo J. Interaction of vitamin K-dependent protein Z with thrombin. Consequences for the amidolytic activity of thrombin and the interaction of thrombin with phospholipids vesicles. J Biol Chem 1991; 266: 10953-8.
8. Hogg PJ, Stenflo J. Interaction of human protein Z with thrombin: evaluation of the species difference in the interaction between bovine and human protein Z and thrombin. Biochem Biophys Res Commun 1991; 178: 801-7.
9. Han X, Fiehler R, Broze GJ Jr. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci USA 1998; 95: 9250-5.
10. Han X, Fiehler R, Broze GJ Jr. Characterization of the protein Z-dependent protease inhibitor. Blood 2000; 96: 3049-55.
11. Yin ZF, Huang ZF, Cui J, et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci USA 2000; 97: 6734-8.
12. Undar L, Karadogan I, Ozturk F. Plasma protein Z levels inversely correlate with plasma interleukin-6 levels in patients with acute leukaemia and non-Hodgkin's lymphoma. Thromb Res 1999; 94: 131-4.
13. Vasse M, Denoyelle C, Legrand E, Vannier JP, Soria C. Weak regulation of protein Z biosynthesis by inflammatory cytokines. Thromb Haemost 2002; 87: 350-1.
14. Rice GI, Futers ST, Grant PJ. Identification of novel polymorphisms within the protein Z gene, haplotype distribution and linkage analysis. Thromb Haemost 2001; 85: 1023-4.
15. Lichy C, Kropp S, Dong-Si T, et al. A commom polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke 2004; 35: 40-45.
16. Kemkes-Matthes B, Matthes KJ. Protein Z deficiency: a new cause of bleeding tendency. Thromb Res 1995; 79: 49-55.
17. Gamba G, Bertolino G, Montani N, Spedini P, Balduini CL. Bleeding tendency of unknown origin and protein Z levels. Thromb Res 1998; 90: 291-5.
18. Ravi S, Mauron T, Lammle B, Wuillemin WA. Protein Z in healthy human individuals and in patients with a bleeding tendency. Br J Haematol 1998; 102: 1219-23.
19. Kobelt K, Biasiutti FD, Mattle, HP, Lammie B, Wuillemin WA. Protein Z in ischaemic stroke. Br J Haematol 2001; 114: 169-73.
20. Vasse M, Guegan-Massardier E, Borg JY, Woimant F, Soria C. Frequency of protein Z deficiency in patients with ischaemic stroke. Lancet 2001; 357: 933-4.
21. Lopaciuk S, Bykowska K, Kwiecinski H, Czlonkowska A, Kuczynska-Zardzewialy A. Protein Z in young survivors of ischemic stroke. Thromb Haemost 2002; 88: 536.
22. Heeb MJ, Paganini-Hill A, Griffin JH, Fisher M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis 2002; 29: 139-44.
23. McQuillan A, Eikelboom J, Hankey G, et al. Protein Z in ischemic stroke and its etiologic subtypes. Stroke 2003; 34: 2415-9.
24. Ayoub N, Esposito G, Barete S, Soria C, Piette JC, Francès C. Protein Z deficiency in antiphospholipid-negative Sneddon's syndrome. Stroke 2004; 35: 1329-32.
25. Gris JC, Quere I, Dechaud E, et al. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood 2002; 99: 2606-8.
26. Gris JC, Amadio C, Mercier E, et al. Anti-protein Z antibodies in women with pathological pregnancies. Blood 2003; 101: 4850-2.
27. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103: 3695-9.
28. Steffano B, Forastiero R, Martinuzzo M, Kordich L. Low plasma protein Z in patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis 2001; 12: 411-2.
29. McColl MD, Deans A, Maclean P, Tait RC, Greer IA, Walker ID. Plasma protein Z deficiency is common in women with antiphospholipid antibodies. Br J Haematol 2003; 120: 913-4.
30. Forastiero RR, Martinuzzo ME, Lu L, Broze GJ Jr. Autoimmune antiphospholipid antibodies impair the inhibition of activated factor X by protein Z/protein Z-dependent protease inhibitor. J Thromb Haemost 2003; 1: 1764-70.
31. Usalan C, Erdem Y, Altun B, et al. Protein Z levels in haemodialysis patients. Int Urol Nephrol 1999; 31: 541-5.
32. Malyszko J, Skrzydlewska E, Malyszko S, Mysliwiec M. Protein Z, a vitamin K-dependent protein in patients with renal failure. J Thromb Haemost 2003; 1: 195-6.
33. Kemkes-Matthes B, Nees M, Kuhnel G, Matzdorff A, Matthes KJ. Protein Z influences the prothrombotic phenotype in Factor V Leiden patients. Thromb Res 2002; 106: 183-5.
34. Marco P, Marin F, Garcia A, Roldan V, Lip GY. Do protein Z levels influence the prothrombotic state in atrial fibrillation? Thromb Res 2002; 106: 269-70.
35. Ozturk MA, Ozbalkan Z, Onat AM, et al. Decreased protein Z concentrations complicating the hypercoagulable state of Behcet's disease. Clin Appl Thromb Haemost 2003; 9: 259-63.
36. Koutroubakis I, Theodoropoulou A, Sfiridaki A, Kouroumalis E. Low plasma protein Z levels in patients with ischemic colitis. Dig Dis Sci 2003; 48: 1673-6.
37. Fedi S, Sofi F, Brogi D, et al. Low protein Z plasma levels are independently associated with acute coronary syndromes. Thromb Haemost 2003; 90:1173-8.
38. Broze GJ Jr. Protein-Z and thrombosis. Lancet 2001;357:900-1.