Genetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida

Human Molecular Genetics

Volumn 5, Issue 5, 1996, Pages 669-674

  Morrison, Katie ^a   Papapetrou, Charalambos ^a   Attwood, John ^a   Hol, Frans ^b   Lynch, Sally A ^c   Sampath, Anu ^a   Hamel, Ben ^b   Burn, John ^c   Sowden, Jane ^a   Stott, David ^d   Mariman, Edwin ^b   Edwards, Yvonne H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Dept Hum Genet Newcastle upon T ^*  (United Kingdom)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; TRANSCRIPTION FACTOR;

ALLELE; ARTICLE; CHROMOSOME 6; CONGENITAL MALFORMATION; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; FEMALE; GENE FREQUENCY; GENE LOCATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; INHERITANCE; MAJOR CLINICAL STUDY; MALE; MALE STERILITY; MESODERM; NEURAL TUBE DEFECT; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SPINA BIFIDA;

ALLELES; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; DNA-BINDING PROTEINS; FEMALE; FETAL PROTEINS; HOMOZYGOTE; HUMANS; INTRONS; LINKAGE (GENETICS); MALE; MICE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SPINAL DYSRAPHISM; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS;

EID: 9244225669     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/5.5.669     Document Type: Article

References (37)

1. Dobrovolskaïa-Zavadskaïa, N. (1927) Sur la mortification spontanée de la queue chez la souris nouveau-née et sure l'existence d'un caractère heriditaire 'non-viable'. C. R. Soc. Biol., 97, 114-116.
2. Beddington, R.S.P., Rashbass, R and Wilson, V. (1992) Brachyury - a gene affecting mouse gastrulation and early organogenesis. Development, Supplement, 157-165.
3. Wilson, V., Rashbass, P. and Beddington, R.S.P. (1993) Chimeric analysis of T (Brachyury) gene function Development, 117, 1321-1331.
4. Wilkinson, D.G., Bhatt, S. and Herrmann, B.G. (1990) Expression pattern of the mouse T gene and its role in mesoderm formation. Nature, 343, 657-659.
5. Schulte-Merker, S., Ho, R.K., Herrmann, B.G and Nüsslein-Volhard, C. (1992) The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development, 116, 1021-1032.
6. Kispert, A. and Herrmann, B.G. (1993) The Brachyury gene encodes a novel DNA binding protein. EMBO J., 12, 3211-3220.
7. Kispert, A., Koschorz, B. and Herrmann, B.G. (1995) The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J., 14, 4763-4772.
8. Smith, J.C., Price, B.M.J., Green, J.B.A , Weigel, D. and Herrmann, B.G. (1991) Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell, 67, 79-87.
9. Schulte-Merker, S and Smith, J.C. (1995) Mesoderm formation in response to Brachvury requires FGF signalling. Curr. Biol., 5, 62-67.
10. Kispert, A., Ortner, H., Cooke, J. and Herrmann, B.G. (1995) The chick brachyury gene: developmental expression pattern and response to axial induction by localized activin. Devel. Biol., 168, 406-415.
11. Yasuo, H. and Satoh, N. (1993) Function of venebrate T gene. Nature, 364, 582-583.
12. Edwards, Y.H , Putt, W., Lekoape, K., Stott, D., Fox, M. and Sowden, J. (1995) The human homologue (Hu-T) of the mouse T (Brachyury) gene; gene structure, cDNA sequence and assignment to chromosome 6q27. Genome Res., in press
13. Schulte-Merker, S., van Eeden, F J.M., Halpern, M.E., Kimmel, C.B. and Nüsslein-Volhard, C. (1994) no tail (ntl) is the zebrafish homologue of the mouse T(Brachyury) gene. Development, 120, 1009-1015.
14. Silver, L.M (1993) The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive. Trends Genet., 9, 250-254.
15. Forejt, J., Artzt, K., Barlow, D , Hamvas, R.M.J., Fischer-Lindahl, K., Lyon, M F., Klein, J. and Silver, L. (1994) Report of the committee for mouse chromosome 17. Mammalian Genome, 5, 238-250
16. Islam, S.D., Pilder, S.H., Decker, CL , Cebra-Thomas, J.A. and Silver, L.M. (1993) The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. Hum. Mol. Genet., 2, 2075-2079.
17. Blanché, H , Wright, L.G., Vergnaud, G., de Gouyon, B , Lauthier, V., Silver, L.M , Dausset, J. Cann, H M. and Spielman, R S. (1992) Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG. Genomics, 12, 826-828.
18. Amos, D.B., Ruderman, N., Mendell, N. and Johnson, A.H. (1975) Linkage between HLA and spinal development. Transplant. Proc., 7, 93-95.
19. Bobrow, M., Bodmer, J.G., Bodmer, W.F., McDevitt, H.O., Lorber, J and Swift, P.N. (1975) The search for a human equivalent of the mouse T-locus. Negative results from a study of HLA types in spina bifida. Tissue Antigens, 5, 234-237.
20. Fellous, M., Hors, J., Bone, J., Dausset, J. and Jacob, F. (1979) Are there human analogs of the mouse T-locus in central nervous system malformations? Birth Defects Orig. Art. Ser., XV, 93-104.
21. Emery, A.E.H. (1986) Methodology in Medical Genetics: An Introduction to Statistical Methods. Churchill Livingstone,
22. Spielman, R.S., McGinnis, R.E. and Ewens, W.J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516.
23. Ott, J. (1991) Analysis of Human Genetic Linkage. The Johns Hopkins University Press.
24. Terranato, L., Jodice, C., Blasi, P., Loizedda, A., Contu, L., Buard, J., Vergnaud, G., Humphries, P., Kumar-Singh, R., Massart, C. and Cann, H. (1994) The EUROGEM map of human chromosome 6. Eur. J. Hum. Genet., 2, 214-215.
25. Gyapay, G., Morissette, J., Vignal, A., Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M. and Weissenbach, J. (1994) The 1993-94 Genethon Human Genetic Linkage Map. Nature Genet., 7, 246-279.
26. Murray, J.C. (1994) Updated integrated maps. Cooperative Human Linkage Center (CHCL) Report, Special Edition V2.5 Maps,
27. Holmes, L.B. (1994) Ciba Foundation Symposium 181 Neural Tube Defects. John Wiley & Sons.
28. Neumann, P.E., Frankel, W.N., Letts, V.A., Coffin, J.M., Copp, A.J. and Bernfield, M. (1994) Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice. Nature Genet , 6, 357-362.
29. Letts, A., Schork, N., Copp, A., Bernfield, M. and Frankel, W. (1995) A curly-tail modifier locus, MCT1, on mouse chromosome 17. Genomics, 29, 719-724.
30. Chatkupt, S , Hol, F.A., Shugart, YY., Geurds, M.P.A., Stenroos, E.S., Koenigsberger, M.R., Hamel, B.C.J., Johnson, W.G. and Mariman, E.C.M. (1995) Absence of linkage between familial neural tube defects and PAX3 gene. J. Med. Genet., 32, 200-204.
31. Hol, F.A., Geurds, M.P.A., Hamel, B.C.J. and Mariman, E.C.M. (1995) An ammo acid substitution in PAX1 in a child with spina bifida and indications for allelic association of the PAX3 gene with human neural tube defects. Am. J. Hum. Genet., 4, A215.
32. Group, M.V.S.R. (1991) Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet. 338, 131-137.
33. Van der Put, N., Steegers-Theunissen, R., Frosst, P., Trijbels, F., Esjes, T., van den Heuvel, L., Mariman, E., den Heyer, M , Rozen, R. and Blom, H. (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet, 346, 1070-1071.
34. Wilson, V., Manson, L , Skarnes, W.C. and Beddington, R S.P. (1995) The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation Development, 121, 877-886.
35. Gruneberg, H. (1958) Genetical studies on the skeleton of the mouse, XXIII. The development of Brachyury and Anury. J. Embryol. Exp. Morphol., 6, 424-443.
36. Rao, Y. (1994) Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor. Genes Dev., 8, 939-947.
37. Dausset, J , Cann, H , Cohen, D., Lathrop, M., J-M., L. and White, R. (1990) CEPH: collaborative genetic mapping of the human genome. Genomics, 6, 575-577