Difference in mGluR5 Interaction between Positive Allosteric Modulators from Two Structural Classes

Annals of the New York Academy of Sciences

Volumn 1003, Issue , 2003, Pages 481-484

  Williams Jr , David L ^a   O'Brien, Julie A ^a   Lemaire, Wei ^a   Chen, Tsing Bau ^a   Chang, Raymond S L ^a   Jacobson, Marlene A ^a   Ha, Sookhee ^a   Wisnoski, David D ^a   Lindsley, Craig W ^a   Sur, Cyrille ^a   Duggan, Mark E ^a   Pettibone, Douglas J ^a   Conn, P Jeffrey ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric modulators; mGluR

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,3' DIFLUOROBENZALDAZINE; 3,5 DIHYDROXYPHENYLGLYCINE; BENZAMIDE DERIVATIVE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; N [4 CHLORO 2 [(1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL)METHYL]PHENYL] 2 HYDROXYBENZAMIDE; QUISQUALIC ACID; UNCLASSIFIED DRUG;

AGONIST; ALLOSTERISM; ANIMAL CELL; CALCIUM TRANSPORT; CHO CELL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING SITE; DRUG COMPETITION; DRUG POTENTIATION; NONHUMAN;

ANIMALIA;

EID: 9144269998     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.059     Document Type: Conference Paper

References (3)

1. SCHOEPP, D.D., D.E. JANE & J.A. MONN. 1999. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacol. 38: 1431-1476
2. CHRISTOPOULOS, A. 2002. Allosteric binding sites on cell surface receptors: novel targets for drug discovery. Nature Rev. Drug Disc. 1: 198-210.
3. 3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg. Med. Chem. Lett. 13: 345-348.