Newer insights into the aetiology and pathogenesis of myeloperoxidase associated autoimmunity

Japanese Journal of Infectious Diseases

Volumn 57, Issue 5, 2004, Pages

  Schmitt, Wilhelm H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; ANTITHYROID AGENT; AUTOANTIBODY; CARBIMAZOLE; CD18 ANTIGEN; HYDRALAZINE; MYELOBLASTIN; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROPYLTHIOURACIL; SILICON DIOXIDE; THIAMAZOLE;

AUTOIMMUNITY; B LYMPHOCYTE; CHURG STRAUSS SYNDROME; CONFERENCE PAPER; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENETIC POLYMORPHISM; HEREDITY; HUMAN; LEUKOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RAT; RISK ASSESSMENT; SYSTEMIC VASCULITIS; T LYMPHOCYTE; WEGENER GRANULOMATOSIS;

ANIMALS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; B-LYMPHOCYTES; HUMANS; PEROXIDASE; T-LYMPHOCYTES; VASCULITIS;

EID: 9144256691     PISSN: 13446304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Rutgers, A., Heeringa, P. and Tervaert, J. W. (2003): The role of myeloperoxidase in the pathogenesis of systemic vasculitis. Clin. Exp. Rheumatol., 21, S55-63.
2. Gencik, M., Meller, S., Borgmann, S., Sitter, T., Menezed Saecker, A. M. Fricke, H. and Epplen, J. T. (2000): The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides. Clin. Immunol., 94, 9-12.
3. Day, C. J.,Hewins, P. and Savage, C. O. (2003): New developments in the pathogenesis of ANCA-associated vasculitis. Clin. Exp. Rheumatol., 21, S35-48.
4. Yang, J. J., Pendergraft, W. F., Alcorta, D. A., Nachman, P. H., Hogan, S. L., Thomas, R. P., Sullivan, P., Jennette, J.C., Falk, R. J. and Preston, G. A. (2004): Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. J. Am. Soc. Nephrol., 15, 2103-2114.
5. Xiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R. J. and Jennette, J. C. (2002): Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest., 110, 995-963.
6. Schmitt, W. H., Hagen, E. C., Neumann, I., Nowack, R., Flores-Suarez, L. F. and van der Woude, F. J. (2004): Treatment of refractory Wegener's granulomatosis with antithymocyte globulin (ATG): An open study in 15 patients. Kidney Int., 65, 1440-1448.
7. Clayton, A. R. and Savage, C. O. (2003): Production of antineutrophil cytoplasm antibodies derived from circulating B cells in patients with systemic vasculitis. Clin. Exp. Immunol., 132, 174-179.
8. Pendergraft, W. F. 3rd., Preston, G. A., Shah, R. R., Tropsha, A., Carter, C. W. Jr., Jennette, J. C. and Falk, R. J. (2004): Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat. Med., 10, 72-79.