hnRNP L enhances sensitivity of the cells to KW-2189

International Journal of Cancer

Volumn 108, Issue 5, 2004, Pages 679-685

  Taguchi, Fumiko ^a,c   Kusaba, Hitoshi ^a   Asai, Akira ^d   Iwamoto, Yasuo ^a   Yano, Keiichi ^d   Nakano, Hirofumi ^d   Mizukami, Tamio ^d   Saijo, Nagahiro ^b   Kato, Harubumi ^c   Nishio, Kazuto ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Duocarmycin; HnRNP L; KW 2189; Minor groove binder; Nuclear localization signal

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L; PIBROZELESIN;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DELETION MUTANT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG CARCINOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN L; HUMANS; LUNG NEOPLASMS; MICE; MUTATION; NUCLEAR PROTEINS; PYRROLIDINONES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 9144252074     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11616     Document Type: Article

References (21)

1. Dreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 1993;62:289-321.
2. Jin W, McCutcheon IE, Fuller GN, Huang ES, Cote GJ. Fibroblast growth factor receptor-1 α-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. Cancer Res 2000;60:1221-4.
3. Sueoka E, Goto Y, Sueoka N, Kai Y, Kozu T, Fujiki H. Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers. Cancer Res 1999;59:1404-7.
4. Shih SC, Claffey KP. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem 1999;274:1359-65.
5. Liu X, Mertz JE. HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev 1995;9:1766-80.
6. Ogasawara H, Nishio K, Takeda Y, Ohmori T, Kubota N, Funayama Y, Ohira T, Kuraishi Y, Isogai Y, Saijo N. A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res 1994;85:418-25.
7. Ogasawara H, Nishio K, Kanzawa F, Lee YS, Funayama Y, Ohira T, Kuraishi Y, Isogai Y, Saijo N. Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11. Jpn J Cancer Res 1995;86:124-9.
8. Ogasawara H, Nishio K, Ishida T, Arioka H, Fukuoka K, Saijo N. In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells. Jpn J Cancer Res 1997;88:1033-7.
9. Asai A, Yano K, Mizukami T, Nakano H. Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells. Cancer Res 1999;59:5417-20.
10. Kasahara K, Fujiwara Y, Nishio K, Ohmori T, Sugimoto Y, Komiya K, Matsuda T, Saijo N. Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. Cancer Res 1991;51:3237-42.
11. Ohmori T, Morikage T, Sugimoto Y, Fujiwara Y, Kasahara K, Nishio K, Ohta S, Sasaki Y, Takahashi T, Saijo N. The mechanism of the difference in cellular uptake of platinum derivatives in non-small cell lung cancer cell line (PC-14) and its cisplatin-resistant subline (PC-14/CDDP). Jpn J Cancer Res 1993;84:83-92.
12. Hahm B, Cho OH, Kim JE, Kim YK, Kim JH, Oh YL, Jang SK. Polypyrimidine tract-binding protein interacts with HnRNP L. FEBS Lett 1998;425:401-6.
13. Kalderon D, Richardson WD, Markham AF, Smith AE. Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 1984;311:33-8.
14. Lanford RE, Butel JS. Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell 1984;37:801-13.
15. Wen W, Meinkoth JL, Tsien RY, Taylor SS. Identification of a signal for rapid export of proteins from the nucleus. Cell 1995;82:463-73.
16. Fischer U, Huber J, Boelens WC, Mattaj IW, Luhrmann R. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 1995;82:475-83.
17. Mandal M, Vadlamudi R, Nguyen D, Wang RA, Costa L, Bagheri-Yarmand R, Mendelsohn J, Kumar R. Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function. J Biol Chem 2001;276:9699-704.
18. Asai A, Nagamura S, Saito H, Takahashi I, Nakano H. The reversible DNA-alkylating activity of duocarmycin and its analogues. Nucleic Acids Res 1994;22:88-93.
19. Okamoto A, Asai A, Saito H, Okabe M, Gomi K. Differential effect of duocarmycin A and its novel derivative DU-86 on DNA strand breaks in HeLa S3 cells. Jpn J Cancer Res 1994;85:1304-11.
20. Kim JH, Hahm B, Kim YK, Choi M, Jang SK. Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. J Mol Biol 2000;298:395-405.
21. Kamma H, Satoh H, Matusi M, Wu WW, Fujiwara M, Horiguchi H. Characterization of hnRNP A2 and B1 using monoclonal antibodies: intracellular distribution and metabolism through cell cycle. Immunol Lett 2001;76:49-54.