Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-I and Tropomodulin 4

BMC Genomics

Volumn 2, Issue , 2001, Pages

  Cox, Patrick R ^a   Siddique, Teepu ^a,b   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; PROTEIN YL 1; TROPOMODULIN; TROPOMODULIN 2; TROPOMODULIN 4; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CASE REPORT; CONTROLLED STUDY; DNA DETERMINATION; EXON; GENE AMPLIFICATION; GENE CONTROL; GENE MUTATION; GENE STRUCTURE; GENETIC ORGANIZATION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SEQUENCE ANALYSIS; SUPPRESSOR GENE;

EID: 9144248619     PISSN: 14712164     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2164-2-7     Document Type: Article

References (42)

1. Weber A, Pennise CR, Babcock GG, Fowler VM: Tropomodulin caps the pointed ends of actin filaments. J Cell Biol 1994, 127:1627-1635
2. Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S: Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. J Biol Chem 1992, 267:2616-2621
3. Sussman MA, Sakhi S, Barrientos P, Ito M, Kedes L: Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development. Circ Res 1994, 75:221-232
4. Ito M, Swanson B, Sussman MA, Kedes L, Lyons G: Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev Biol 1995, 167:317-328
5. Watakabe A, Kobayashi R, Helfman DM: N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. J Cell Sci 1996, 109:2299-2310
6. Sussman MA, Ito M, Daniels MP, Flucher B, Buranen S, Kedes L: Chicken skeletal muscle tropomodulin: novel localization and characterization. Cell Tissue Res 1996, 285:287-296
7. Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM: Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. J Biol Chem 1999, 274:28466-28475
8. Cox PR, Zoghbi HY: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics 2000, 63:97-107
9. Sun HQ, Yamamoto M, Mejillano M, Yin HL: Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 1999, 274:33179-33182
10. Caldwell JE, Heiss SG, Mermall V, Cooper JA: Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin. Biochemistry 1989, 28:8506-8514
11. Kuhlman PA, Hughes CA, Bennett V, Fowler VM: A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. J Biol Chem 1996, 271:7986-7991
12. Littlefield R, Fowler VM: Defining actin filament length in striated muscle: rulers and caps or dynamic stability? Annu Rev Cell Dev Biol 1998, 14:487-525
13. Gregorio CC, Weber A, Bondad M, Pennise CR, Fowler VM: Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes. Nature 1995, 377:83-86
14. Sussman MA, Baque S, Uhm CS, Daniels MP, Price RL, Simpson D, Terracio L, Kedes L: Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ Res 1998, 82:94-105
15. Sussman MA, Welch S, Cambon N, Klevitsky R, Hewett TE, Price R, Witt SA, Kimball TR: Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J Clin Invest 1998, 101:51-61
16. Thierfelder L, Watkins H, MacRae C, Lamas R, McKenna W, Vosberg HP, Seidman JG, Seidman CE: Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 1994, 77:701-712
17. Tanigawa G, Jarcho JA, Kass S, Solomon SD, Vosberg HP, Seidman JG, Seidman CE: A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell 1990, 62:991-998
18. Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG: A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell 1990, 62:999-1006
19. Poetter K, Jiang H, Hassanzadeh S, Master SR, Chang A, Dalakas MC, Rayment I, Sellers JR, Fananapazir L, Epstein ND: Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. Nat Genet 1996, 13:63-69
20. Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, Boivin GP, Wolska B, Evans C, Solaro RJ, Wieczorek DF: Mouse model of a familial hypertrophic cardiomyopathy mutation in alphatropomyosin manifests cardiac dysfunction. Circ Res 1999, 85:47-56
21. McKenna WJ: Hypertrophic cardiomyopathy: an update. Cardiologia 1993, 38:277-281
22. Hentati A, Ouahchi K, Pericak-Vance MA, Nijhawan D, Ahmad A, Yang Y, Rimmler J, Hung W, Schlotter B, Ahmed A, Ben Hamida M, Hentati F, Siddique T: Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15ql5-q22 markers. Neurogenetics 1998, 2:55-60
23. van der Kooi AJ, van Meegen M, Ledderhof TM, McNally EM, de Visser M, Bolhuis PA: Genetic localization of a newly recognized autosomal dominant limb-girdle muscular dystrophy with cardiac involvement (LGMD1B) to chromosome 1q11-21. Am J Hum Genet 1997, 60:891-895
24. Muchir A, Bonne G, van der Kooi AJ, van Meegen M, Baas F, Bolhuis PA, de Visser M, Schwartz K: Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum Mol Genet 2000, 9:1453-1459
25. Horikawa I, Tanaka H, Yuasa Y, Suzuki M, Oshimura M: Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNAbinding ability. Biochem Biophys Res Commun 1995, 208:999-1007
26. Horikawa I, Tanaka H, Yuasa Y, Suzuki M, Shimizu M, Oshimura M: Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. Exp Cell Res 1995, 220:11-17
27. Chu X, Thompson D, Yee LJ, Sung LA: Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. Gene 2000, 256 271-281
28. Mount SM: Genomic sequence, splicing, and gene annotation. Am J Hum Genet 2000, 67:788-792
29. Burset M, Seledtsov LA, Solovyev VV: Analysis of canonical and non-canonical splice sites in mammalian genomes. Nucleic Acids Res 2000, 28:4364-4375
30. Fears S, Mathieu C, ZeIeznik-Le N, Huang S, Rowley JD, Nucifora G: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. Proc Natl Acad Sci USA 1996, 93: 642-1647
31. Soderholm J, Kobayashi H, Mathieu C, Rowley JD, Nucifora G: The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivator. Leukemia 1997, 11:352-358
32. Magrangeas F, Pitiot G, Dubois S, Bragado-Nilsson E, Cherel M, Jobert S, Lebeau B, Boisteau O, Lethe B, Mallet J, Jacques Y, Minvielle S: Cotranscription and intergenic splicing of human galactose- 1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution. J Biol Chem 1998, 273:16005-16010
33. Kowalski PE, Freeman JD, Mager DL: Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. Genomics 1999, 57:371-379
34. Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D: Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol 1999, 292:797-817
35. Gray IC, Nobile C, Muresu R, Ford S, Spurr NK: A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 1995, 28:328-332
36. Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily [published erratum appears in Biochemistry 1993 Feb 9;32(5):1390]. Biochemistry 1991, 30: 247-3255
37. Zaphiropoulos PG: RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver. Nucleic Acids Res 1999, 27:2585-2590
38. Finta C, Zaphiropoulos PG: The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. Genomics 2000, 63:433-438
39. Millar JK, Christie S, Semple CA, Porteous DJ: Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISCI, a gene disrupted by a translocation segregating with schizophrenia [In Process Citation]. Genomics 2000, 67:69-77
40. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, dark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Francesco VD, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang ZY, Wang A, Wang X, Wang J, Wei MH, Wides R, et al: The Sequence of the Human Genome. Science 2001, 291:1304-1351
41. Conley CA, Fritz-Six KL, Almenar-Queralt A, Fowler VM: Leiomodins: larger members of the tropomodulin (Tmod) gene family. Genomics 2001, 73:127-39
42. Littlefield R, Almenar Queralt A, Fowler VM: Actin dynamics at pointed ends regulates thin filament length in striated muscle. Nat Cell Biol 2001, 6:544-51