Overexpression of Her2/neu is observed in one third of adult acute lymphoblastic leukemia patients and is associated with chemoresistance in these patients [7]

Haematologica

Volumn 89, Issue 11, 2004, Pages 1399-1401

  Chevallier, Patrice ^a   Rabillard, Nelly ^a   Wuilleme Taumi, Saraya ^a   Méchinaud, Françoise ^a   Harousseau, Jean Luc ^a   Avet Loiseau, Hervé ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

Acute lymphoblastic leukemia; FACS analysis; HER2 neu expression

Indexed keywords

TRASTUZUMAB;

CANCER PATIENT; CLINICAL TRIAL; COMPARATIVE STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG TOLERANCE; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; LETTER; LYMPHATIC LEUKEMIA; ONCOGENE NEU; PROGNOSIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, ERBB-2; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L2; MALE; MIDDLE AGED;

EID: 9144247729     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (4)

1. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the Her-2/neu oncogene. Science 1987;235:177-82.
2. Berchuck A, Kamel A, Whitaker R, Kerns B, Olt G, Kinney R, et al. Overexpression of Her-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990;50:4087-91.
3. Bühring HJ, Sures I, Jallal B, Weiss U, Busch FW, Ludwig WD, et al. The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia. Blood 1995; 86:1916-23.
4. Müller MR, Grünebach F, Kayser K, Vogel W, Nencioni A. Brugger W, et al. Expression of Her-2/neu on acute lymphoblastic leukemias: implications for the development of immunotherapeutic approaches. Clin Cancer Res 2003;9:3448-53.