Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-β1

British Journal of Haematology

Volumn 124, Issue 2, 2004, Pages 211-220

  Kuroda, Hiroyuki ^a   Matsunaga, Takuya ^a   Terui, Takeshi ^a   Tanaka, Ikuta ^a   Takimoto, Rishu ^a   Fujikawa, Koshi ^a   Takayama, Tetsuji ^a   Kato, Junji ^a   Hirayama, Yasuo ^b   Sakamaki, Sumio ^b   Kohda, Kyuhei ^c   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Internal Medicine   (Japan)

^c ASAHIKAWA RED CROSS HOSPITAL   (Japan)

Author keywords

Essential thrombocythaemia; Megakaryocytes; Smad4; Thrombopoietin; Transforming growth factor

Indexed keywords

SMAD4 PROTEIN; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTHEMIA;

ADULT; AGED; AGED, 80 AND OVER; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; MALE; MEGAKARYOCYTES; MIDDLE AGED; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; THROMBOCYTHEMIA, HEMORRHAGIC; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 9144235402     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04755.x     Document Type: Article

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