Genomic structure and cloning of two transcript isoforms of human Sp8

BMC Genomics

Volumn 5, Issue , 2004, Pages

  Milona, Maria Athina ^a   Gough, Julie E ^b   Edgar, Alasdair J ^c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN; BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COMPLEMENTARY DNA; DNA BINDING PROTEIN; SP8 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CHONDROGENESIS; CHROMOSOME 7P; CONTROLLED STUDY; FORELIMB; GENE CONTROL; GENE MAPPING; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOMICS; HINDLIMB; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHOBICITY; MOLECULAR CLONING; NERVE FIBER; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOSARCOMA CELL; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; ZEBRA FISH; ANIMAL; ANTIBODY SPECIFICITY; C3H MOUSE; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; CHROMOSOME 7; CHROMOSOME MAP; COMPARATIVE STUDY; EXON; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MOUSE; OSTEOSARCOMA; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

DANIO RERIO; MURINAE; PRIMATES; RODENTIA;

AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEINS; CELL LINE; CELL LINE, TUMOR; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 7; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EXONS; GENE EXPRESSION REGULATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; OSTEOBLASTS; OSTEOSARCOMA; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH PROTEINS; ZINC FINGERS;

EID: 9144234302     PISSN: 14712164     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2164-5-86     Document Type: Article

References (36)

1. WS Dynan, R Tjian: Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II Cell 1983, 32: 669-80.
2. J Yoo, MJ Jeong, BM Kwon, MW Hur, YM Park, MY Han: Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells. J Biol Chem 2002, 277: 11904-9.
3. KJ Kolell, DL Crawford: Evolution of Sp transcription factors. Mol Biol Evol 2002, 19: 216-22.
4. B Yu, PK Datta, S Bagchi: Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res 2003, 31: 5368-76.
5. C Chadjichristos, C Ghayor, M Kypriotou, G Martin, E Renard, L Ala-Kokko, G Suske, B de Crombrugghe, JP Pujol, P Galera: Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem 2003, 278: 39762-72.
6. H Gollner, C Dani, B Phillips, S Philipsen, G Suske: Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev 2001, 106: 77-83.
7. K Nakashima, X Zhou, G Kunkel, Z Zhang, JM Deng, RR Behringer, B de Crombrugghe: The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108: 17-29.
8. MA Milona, JE Gough, AJ Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. BMC Genomics 2003, 4: 43.
9. SM Bell, CM Schreiner, RR Waclaw, K Campbell, SS Potter, WJ Scott: Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A 2003, 100: 12195-200.
10. D Treichel, F Schock, H Jackle, P Gruss, A Mansouri: mBtd is required to maintain signaling during murine limb development. Genes Dev 2003, 17: 2630-5.
11. SM Cohen, G Jurgens: Mediation of Drosophila head development by gap-like segmentation genes. Nature 1990, 346: 482-5.
12. EA Wimmer, H Jackle, C Pfeifle, SM Cohen: A Drosophila homologue of human Sp1 is a head-specific segmentation gene. Nature 1993, 366: 690-4.
13. M Kozak: An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 1987, 15: 8125-48.
14. S Philipsen, G Suske: A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 1999, 27: 2991-3000.
15. Y Okazaki, M Furuno, T Kasukawa, J Adachi, H Bono, S Kondo, I Nikaido, N Osato, R Saito, H Suzuki, et al: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs Nature 2002, 420: 563-73.
16. EA Wimmer, G Frommer, BA Purnell, H Jackle: buttonhead and D-Sp1: a novel Drosophila gene pair. Mech Dev 1996, 59: 53-62.
17. A Beermann, M Aranda, R Schroder: The Sp8 zinc-finger transcription factor is involved in allometric growth of the limbs in the beetle Tribolium castaneum. Development 2004, 131: 733-42.
18. VA Narayan, RW Kriwacki, JP Caradonna: Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. J Biol Chem 1997, 272: 7801-9.
19. CM Shea, CM Edgar, TA Einhorn, LC Gerstenfeld: BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem 2003, 90: 1112-27.
20. T Katagiri, A Yamaguchi, T Ikeda, S Yoshiki, JM Wozney, V Rosen, EA Wang, H Tanaka, S Omura, T Suda: The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 1990, 172: 295-9.
21. EA Wang, DI Israel, S Kelly, DP Luxenberg: Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 1993, 9: 57-71.
22. F Schock, BA Purnell, EA Wimmer, H Jackle: Common and diverged functions of the Drosophila gene pair D-Sp1 and buttonhead. Mech Dev 1999, 89: 125-32.
23. M Subramaniam, SA Harris, MJ Oursler, K Rasmussen, BL Riggs, TC Spelsberg: Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 1995, 23: 4907-12.
24. LJ Blok, MV Kumar, DJ Tindall: Isolation of cDNAs that are differentially expressed between androgen-dependent and androgen-independent prostate carcinoma cells using differential display PCR. Prostate 1995, 26: 213-24.
25. KR Tau, TE Hefferan, KM Waters, JA Robinson, M Subramaniam, BL Riggs, TC Spelsberg: Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblasts. Endocrinology 1998, 139: 1346-53.
26. KY Choi, SW Lee, MH Park, YC Bae, HI Shin, S Nam, YJ Kim, HJ Kim, HM Ryoo: Spatiotemporal expression patterns of Runx2 isoforms in early skeletogenesis. Exp Mol Med 2002, 34: 426-33.
27. C Banerjee, A Javed, JY Choi, J Green, V Rosen, AJ van Wijnen, JL Stein, JB Lian, GS Stein: Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype Endocrinology 2001, 142: 4026-39.
28. P Ducy, R Zhang, V Geoffroy, AL Ridall, G Karsenty: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997, 89: 747-54.
29. A Hollnagel, V Oehlmann, J Heymer, U Ruther, A Nordheim: Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 1999, 274: 19838-45.
30. AJ Edgar, SL Dover, MN Lodrick, IJ McKay, FJ Hughes, W Turner: Bone Morphogenetic Protein-2 Induces Expression Of Murine Zinc Finger Transcription Factor ZNF450. J. Cell. Biochem. In press.
31. V Prince: The Hox Paradox: More complex(es) than imagined Dev Biol 2002, 249: 1-15.
32. ID Xynos, AJ Edgar, LD Buttery, LL Hench, JM Polak: Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem Biophys Res Commun 2000, 276: 461-5.
33. JE Gough, P Christian, CA Scotchford, CD Rudd, IA Jones: Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair. J Biomed Mater Res 2002, 59: 481-9.
34. SA Harris, RJ Enger, BL Riggs, TC Spelsberg: Development and characterization of a conditionally immortalized human fetal osteoblastic cell line. J Bone Miner Res 1995, 10: 178-86.
35. CL Murphy, A Sambanis: Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. Tissue Eng 2001, 7: 791-803.
36. AJ Edgar, JM Polak: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Biochem Biophys Res Commun 2002, 292: 617-25.