Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas [8]

Haematologica

Volumn 89, Issue 11, 2004, Pages 1401-1403

  Gallardo, Fernando ^a,b   Esteller, Manel ^c   Pujol, Ramon M ^a,b   Costa, Carlota ^a,b   Estrach, Teresa ^b,d   Servitje, Octavio ^b,e  

^a HOSPITAL DEL MAR   (Spain)

^b Cutaneous Lymphoma Netwk Catalonia ^*  (Spain)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Methylation status; MGMT; Primary cutaneous T cell lymphama

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P15; PROTEIN P16; UNCLASSIFIED DRUG;

ADULT; AGED; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DNA METHYLATION; FEMALE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; LETTER; MALE; MYCOSIS FUNGOIDES; PROMOTER REGION; SEZARY SYNDROME;

ADULT; AGED; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA METHYLATION; FEMALE; GENES, P16; HUMANS; LYMPHOMA, T-CELL, CUTANEOUS; MALE; MIDDLE AGED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER REGIONS (GENETICS);

EID: 9144229469     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (9)

1. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
2. Drexler HG. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 1998;12:845-59.
3. Pinyol M, Cobo F, Bea S, Jares P, Nayach I, Fernandez PL, et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. Blood 1998;91:2977-84.
4. Villuendas R, Sanchez-Beato M, Martinez JC, Saez AI, Martinez-Delgado B, Garcia JF, et al. Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression. Am J Pathol 1998;153:887-97.
5. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999;59:793-7.
6. Dolan ME, McRae BL, Ferries-Rowe E, Belanich M, van Seventer GA, Guitart J, et al. O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents. Clin Cancer Res 1999;5:2059-64.
7. Navas IC, Ortiz-Romero PL, Villuendas R, Martinez P, Garcia C, Gomez E, et al. P16 gene alterations are frequent in lesions of mycosis fungoides. Am J Pathol 2000;156:1565-72.
8. Navas IC, Algara P, Mateo M, Martinez P, Garcia C, Rodriguez JL, et al. p16 (INK4a) is selectively silenced in the tumoral progression of mycosis fungoides. Lab Invest 2002;82:123-32.
9. Scarisbrick JJ, Woolford AJ, Calonje E, Photiou A, Ferreira S, Orchard G, et al. Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and Sézary syndrome. J Invest Dermatol 2002;118:493-9.