Induction of microvariant-specific CTL lines reactive to a single amino acid mismatch in bulk cultures using a transfectant expressing a single HLA class I molecule

Journal of Immunology

Volumn 156, Issue 1, 1996, Pages 18-26

  Cereb, Nezih ^a   Yang, Soo Young ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HLA ANTIGEN CLASS 1;

ARTICLE; CHRONIC MYELOID LEUKEMIA; CYTOTOXIC T LYMPHOCYTE; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOLECULAR CLONING; PHENOTYPE; PREDICTION; PRIORITY JOURNAL;

ALLELES; EPITOPES; GENES, MHC CLASS I; HLA-B ANTIGENS; HUMANS; ISOANTIGENS; LEUKEMIA, MYELOID; LYMPHOCYTE CULTURE TEST, MIXED; MULTIGENE FAMILY; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 9044251205     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (79)

1. Anasetti, C., and J. Hansen. 1994. Bone Marrow Transplantation from HLA-Partially Matched Related Donors and Unrelated Volunteer Donors. Blackwell Scientific Publications, Boston, pp. 665-679.
2. Zinkernagel, R. M., and P. C. Doherty. 1979. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction-specificity, function, and responsiveness Adv. Immunol 27.51.
3. Bjorkman, P. J., and P. Parham. 1990. Structure, function, and diversity of class I major histocompatibility complex molecules. Annu. Rev Biochem. 59:253.
4. Bevan, M. J., K. A. Hogquist, and S. C Jameson. 1994. Selecting the T cell receptor repertoire. Science 264:796.
5. von Boehmer, H., H. Hengartner, M. Nabholz, W. Lernhardt, M H. Schreier, and W Haas 1979 Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J. Immunol. 9.592.
6. Nossal, G. J. V 1994 Negative selection. Cell 76:229.
7. Sherman, L. A., and S. Chattopadhyay. 1993. The molecular basis of allorecognition. Annu Rev. Immunol. 11:385.
8. Bluestone, J. A., S. Jameson, S. Miller, and R. Dick H. 1992. Peptide-induced conformational changes in class I heavy chains alter major histocompatibilty complex recognition. J. Exp. Med 176:1757.
9. Heath, W. R., K P. Kane, M. F. Mescher, and L. A. Sherman. 1991. Alloreactive T cells discriminate among a diverse set of endogenous peptides. Proc Natl Acad. Sci. USA 88:5101.
10. Chen, W , J McClusky, S. Rodda, and F. R. Carbone. 1993. Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J. Exp. Med. 177:869
11. Rohren, E. M., J. M. McCormack, and L. R. Pease. 1994. Peptide-induced conformational changes in class I molecules: direct detection by flow cytometry J. Immunol 152:5337.
12. Catipovic, B., J. D. Porto, M. Mage, T. E. Johansen, and J. P. Schneck 1992. Major histocompatibility complex conformational epitopes are peptide specific J Exp. Med. 176:1611.
13. d molecules J. Immunol. 149:3990
14. Pullen, J. K., M. D. Tallquist, R. W Melvold, and L R. Pease. 1994. Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self-peptide J. Immunol. 152:3445.
15. Tussey, L. G., M. Matsui, S. Rowland-Jones, R. Warburton, J. A. Frelinger, and A. McMichael. 1994. Analysis of mutant HLA-A2 molecules: differential effects on peptide binding and CTL recognition J. Immunol. 152.1213.
16. Akolkar, P. N., B Gulwani-Akolkar, R. Pergolizzi, R. D. Bigler, and J Silver. 1993. Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes. J. Immunol. 150:2761.
17. Kisielow, P., H. S. Teh, H Bluthmann, and H. von Boehmer 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730.
18. + T cells. Science 244:214
19. Bhayani, H. R , and S. M. Hedrick. 1991. The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire. J. Immunol. 146: 1093.
20. Arnett, K. L , and P. Parham. 1995. HLA class I nucleotide sequences, 1995, Tissue Antigens 46:217.
21. Parham, P., D. A. Lawlor, C. Lomen, and P. D. Ennis. 1989. Diversity and diversification of HLA-A, -B, and -C alleles. J. Immunol. 142:3937.
22. Bjorkman, P. J., M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley. 1987 Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506
23. Bjorkman, P J , M. A Saper, B Samraoui, W S. Bennett, J. L. Strominger, and D. C. Wiley. 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329.512.
24. Bodmer, J. G., S. G. E Marsh, E. Albert, W F. Bodmer, R E Bontrop, D. Charron, B. Dupont, H. A Erlich, B. Mach, W. R. Mayr, P. Parham, T. Sasasuki, G. M. T. Schreuder, J L, Strominger, A Svejgaard, and P. I. Terasaki. 1995 Nomenclature for factors of the HLA system, 1995. Tissue Antigens 46, 1
25. Fleischhauer, K , N. A. Kernan, R J. O'Reilly, B, Dupont, and S. Y Yang. 1990. Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N Engl. J. Med 323:1818.
26. Beatty, P G., R A Clift, E. Mickelson, B. B. Nisperos, N. Flourney, P. J. Martin, I. E Sanders, P. Stewart, C. D. Buckner, R. Storb, E. D. Thomas, and J. A. Hansen 1985. Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med. 313.765.
27. Anasetti, C , D. Amos, P. G. Beatty, F. R. Appelbaum, W. Bensinger, C. D. Buckner, R. Clift, K Doney, P. J Martin, E Mickelson, B. Nisperos, J O'Quigley, et al 1989. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma N. Engl. J. Med. 320:197.
28. Anasetti, C , P. G. Beatty, R. Storb, P. J Martin, M. Mori, J E. Sanders, E. D. Thomas, and J. A. Hansen. 1990. Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma Hum Immunol. 29:79.
29. McLaughlin-Taylor, E., C. G. Miyada, M. McMillan, and R B. Wallace 1988. Direct demonstration of critical ammo acid residues required for cytotoxic T lymphocyte allorecognition of H-2 class I antigens. Proc. Natl. Acad. Sci. USA 85:3085.
30. Nathenson, S. G , J Geliebter, G. M. Pfaffenbach, and R. A. Zeff 1986. Murine major histocompatibility complex class I mutants: molecular analysis and structure-function implications. Annu Rev. Immunol 4:471.
31. Altman, D. M., D. Wilkinson, H. Ikeda, and J. Trowsdale. 1990. Analysis of antigen presentation using HLA transfectants Immunol Res. 9.57.
32. Mentzer, S. J , J A Barbosa, J L Strominger, P. A. Biro, and S. A. Burakoff. 1986. Species-restricted recognition of transfected HLA-A2 and HLA-B7 by human CTL clones J. Immunol. 137:408.
33. Galocha, B., D Lopez, and J. A. Lopez de Castro 1993 Clonal heterogeneity in LFA-3 and ICAM-1 requirement for lysis by alloreactive T lymphocytes. J Immunol. 150.1653.
34. Koller, T. D., C. Clayberger, J. L. Maryansky, and A M, Krensky. 1987. Human cytolytic T lymphocyte lysis of a murine cell transfected with HLA-A2. J Immunol 138:2044.
35. Demars, R., C. Chang, S. Shaw, P. Reithauer, and P Sondel. 1984. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV transformed lymphoblastoid cells. Hum. Immunol. 11:77.
36. Shimizu, Y., and R. Demars. 1989. Production of human cells expressing individual transferred HLA-A, -B, -C genes using an HLA-A, -B, -C null human cell line. J Immunol 142:3320.
37. Salter, R., and P. Cresswell. 1986. Impaired assembly and transport of HLA-A and -B antigens in a TxB cell hybrid EMBO J. 5:943.
38. Zemmour, J., A. M. Little, D J. Schendel, and P. Parham 1992. The HLA-A,B "negative" mutant cell line ClR expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon. J. Immunol. 148:1941
39. Hammerling, G J., J. W. Chamberlin, O. Dill, S Y. Yang, B. Dupont, S. Weissman, and U Hammerling. 1990. Self-tolerance to HLA in HLA-transgenic mice, focuses antibody responses to allelic differences and evokes antibodies of marrow specificity. Proc. Natl. Acad. Sci. USA 87:235.
40. Yang, S. Y., Y. Morishima, N. H. Collins, T. Alton, M. S. Pollack, E. J Yunis, and B. Dupont. 1984. Comparison of one dimensional IEF patterns for serologically detectable HLA-A and -B allotypes. Immunogenetics 19:217.
41. Long, E. O., S. Rosen-Bronson, D R. Karp, M. Malnati, R. P. Sekaly, and D Jaraquemada. 1991. Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells. Hum. Immunol. 31 229
42. Yang, S. Y. 1989 A standardized method for detection of HLA-A and HLA-B alleles by one-dimensional isoelectric focusing (IEF) gel electrophoresis. In Immunobiology of HLA, vol I. B. Dupont, ed. Springer Verlag, New York, p. 332-335.
43. Cereb, N., J. W. Choi, K. Z Riu, and S Y Yang 1994. HLA-B*5105, a newly identified B51 IEF variant. Tissue Antigens 44.271.
44. Yssel, H., J. E De Vries, M. Koken, W. V. Blitterswijk, and H. Spits. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol. Methods 72:219
45. Ausubel, F. M., R. Brent, R E. Kingston, D D. Moore, J G. Seidman, J. A. Smith, and S Kevin. 1994. Current Protocols in Molecular Biology, vol. I K. Janssen, ed. John Wiley & Sons, Inc., New York, p. 2.9.1.9.6.
46. Maziarz, R. T , S. J. Burakoff, and D. V. Faller. 1990. The regulation of exogenous and endogenous class I MHC genes in a human tumor cell line, K562 Mol. Immunol. 27-135.
47. June, C. H., J. A. Bluestone, L. M. Nadler, and C B. Thompson 1994. The B7 and CD28 recepror families. Immunol Today 15:321.
48. Yang, S. Y. 1989 Population analysis of HLA class I antigens by one-dimensional isoelectric focusing gel electrophoresis workshop report. In Immunobiology of HLA, vol. I. B. Dupont, ed. Springer-Verlag, New York, p. 309.
49. Baur, M P., and J A. Danilovs. 1980. Population Analysis of HLA-A,B,C,DR, and Other Genetic Markers. UCLA Tissue Typing Laboratory, Los Angeles, pp. 955-993.
50. Yang, S. Y., E. Milford, U. Hammerling, and B. Dupont 1989 Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: the B-cell line panel designed for the Tenth International Histocompatibility Workshop, In Immunobiology of HLA, Vol I. B. Dupont, ed. Springer-Verlag, New York, pp 11-19.
51. von Boehmer, H , and W. Haas. 1979 Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen. J. Exp. Med. 150 1134.
52. Keene, J., and J. Forman 1982 Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med. 155:768
53. + helper T cells. J. Exp. Med. 171:1315.
54. Sprent J., and M. Schaefer. 1985. Properties of purified T cell subsets. I In vitro responses to class I vs. class II H-2 alloantigens. J. Exp. Med. 162.2068.
55. Sprent, J , M Schaefer, D Lo, and R. Korngold. 1986. Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences. J. Exp. Med. 163:998.
56. Widmer, M B , and F H. Bach. 1981. Antigen-driven helper cell independent cloned cytolytic T lymphocytes. Nature 294.750.
57. Buller, R. M. L., K. L. Holmes, A. Hugin, T. N. Frederickson, and I H. Morse 1987. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 328:77
58. + cytotoxic T lymphocytes in the absence of exogenous help. J Exp. Med 177.1791
59. Chouaib, S., J. Chehimi, L. Bani, N. Genetet, T. Tursz, F. Gay, G. Trinchieri, and F. Mami-Chouaib. 1994. Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors. Proc. Natl Acad. Sci. USA 91.12659.
60. Boussiotis, V. A., G. J. Freeman, G. Gray, J Gribben, and L M. Nadler. 1993. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 178:1753.
61. Azuma, M , M Cayabyab, J. H. Phillips, and L. L. Lanier. 1993. Requirements for CD28-dependent T cell-mediated cytotoxicity. J. Immunol. 150.2091
62. Cai, Z., and J. Sprent. 1994. Resting and activated T cells display different requirements fur CD8 molecules. J Exp Med 179:2005.
63. Saper, M. A., P. J. Bjorkman, and D C. Wiley. 1991. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J. Mol. Biol 219:277
64. Alexander-Miller, M. A , K Burke, U. H. Koszinowski, T. H. Hansen, and J. M. Conolly 1993 Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity. J. Immunol. 151:1.
65. Racioppi, L , F Ronchese, R. H. Schwarte, and R N Germain. 1991. The molecular basis of class II MHC allelic control of T cell responses J Immunol 147:3718.
66. Keever, C. A , N. Leong, I. Cunningham, E. A. Copelan, B. R. Avalos, J. Klein, N. Kapoor, P. W. Adams, C. G Orosz, P. J. Tutschka, and L. A Baxter-Lowe. 1994. HLA-B44-directed cytotoxic T cells associated with acute graft-versus-host disease following unrelated bone marrow transplantation. Bone Marrow Transplant 14:137
67. Rohren, E. M , L R. Pease, H. L. Ploegh, and T. N. M. Schumacher. 1993. Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference. J. Exp. Med. 177:1713
68. Schumacher, T. N M., G. M. Van Bleek, M. Heemels, K. Deres, K. W. Li, M. Imarai, L N Vernie, S. G Nathenson, and H. L. Ploegh. 1992. Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules. Eur. J. Immunol 22:1405
69. Hurley, C. K., N Steiner, A Wagner, M J Geiger, D D. Eckels, and S Rosen-Bronson. 1993. Nonrandom T cell receptor usage in the allorecognitton of HLA-DR1 microvariation. J. Immunol 150:1314.
70. Bragado, R., P Lauzurica, D. Lopez, and J A. Lopez de Castro. 1990. T cell receptor Vβ-gene usage in a human alloreactive response. J. Exp. Med. 171:1189.
71. Geiger, M I., J. Gorski, and D. D. Eckels 1991 T cell receptor gene segment utilization by HLA-DRI-alloreactive T cell clones. J. Immunol 147:2082.
72. Jones, G. 1973. The number of reactive cells in mouse lymphocyte cultures stimulated by phytohemagglutinin, conconavalin A or histocompatibility antigen. J. Immunol. 111:914.
73. Ford, W. L., and R. C Atkins. 1973. The proportion of lymphocytes capable of recognizing strong transplantation antigens in vivo. Adv. Exp. Med. Biol. 29.255
74. Fisher-Lindahl, K., and D B. Wilson. 1977. Histocompatibility antigen-activated cytotoxic T lymphocytes II. Estimates of the frequency of and specificity of precursors. J. Exp Med 145:508.
75. Robins, P. A., L A. Lettice, P. Rota, J. Santos-Aguado, J. Rothbard, A. J Mc-Michael, and J. L. Strominger. 1989. Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. evidence for discrete locations within HLA-A2 J Immunol 143:4098.
76. Santos-Aguad, J., M A. V. Crimmins, S J. Mentzer, S. J. Burakoff, and J. L Strominger. 1989. Alloreactivity studied with mutants of HLA-A2. Proc. Natl. Acad. Sci. USA 86:8936
77. Jelachich, M. L., E P. Cowen, R. V. Turner, J E. Coligan, and W. E. Biddison 1988. Analysis of the molecular basis of HLA-A3 recognition by cytotoxic T cells using defined mutants of the HLA-A3 molecule. J. Immunol 141:1108.
78. Hogan, K. T., C. Clayberger, E J Bernhard, S. F. Walk, J. P. Ridge, P. Parham. A. M Krensky, and V. H. Engelhard. 1989. A panel of unique HLA-A2 mutant molecules define epitopes recognized by HLA-A2 specific antibodies and cytotoxic T lymphocytes J. Immunol. 142:2097.
79. b alloantigens are as frequent as those reactive against a whole foreign haplotype. J Immunol 124.48