Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: A double-blind, randomized trial

Journal of Infectious Diseases

Volumn 173, Issue 1, 1996, Pages 91-97

  Leport, Catherine ^a   Chêne, Geneviève ^c   Morlat, Philippe ^b   Luft, Benjamin J ^c   Rousseau, Franck ^c   Pueyo, Sophie ^c   Hafner, Richard ^c   Miro, José ^c   Aubertin, Jean ^c   Salamon, Roger ^c   Vildé, Jean Louis ^c  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL SAINT ANDRÉ   (France)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; COTRIMOXAZOLE; DAPSONE; DIDANOSINE; FLUOROURACIL; FOLINIC ACID; MACROLIDE; PENTAMIDINE; PLACEBO; PYRIMETHAMINE; SULFADIAZINE; SULFONAMIDE; ZIDOVUDINE;

ADULT; ARTICLE; BLOOD TOXICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL TOXICITY; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PNEUMOCYSTOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 9044248588     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.1.91     Document Type: Article

References (16)

1. Leport C, Raffi F, Matheron S, et al. Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy. Am J Med 1988;84:94-100.
2. Dannemann B, McCutchan JA, Israelski D, et al. Treatment of toxoplasmic encephalitis in patients with AIDS: a randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. Ann Intern Med 1992;116:33-43.
3. Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis 1992;15:211-22.
4. Katlama C, De Wit S, Guichard A, et al. A randomized European trial comparing pyrimethamine-clindamycin to pyrimethamine-sulfadiazine in AIDS toxoplasmic encephalitis [abstract 1215]. In: Program and abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy (Anaheim, CA). Washington, DC: American Society for Microbiology, 1992.
5. Beaman MH, Luft BJ, Remington JS. Prophylaxis for toxoplasmosis in AIDS. Ann Intern Med 1992;117:163-4.
6. Grant IH, Gold JWM, Rosenblum M, Niedzwiecki D, Armstrong D. Toxoplasma gondii serology in HIV-infected patients: the development of central nervous system toxoplasmosis in AIDS. AIDS 1990;4:519-21.
7. Thiermann E, Apt W, Atlas A, Lorca M, Olguin J. A comparative study of some combined treatment regimens in acute toxoplasmosis in mice. Am J Trop Med Hyg 1978;27:747-50.
8. Grossman PL, Remington JS. The effect of trimethoprim plus sulfamethoxazole on Toxoplasma gondii in vitro and in vivo. Am J Trop Med Hyg 1979;28:445-55.
9. Jaffe JS, Abrams DI, Ammann AJ, Lewis BJ, Golden JA. Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet 1983;2:1109-11.
10. Eyles DE, Coleman N. Synergistic effect of sulfadiazine and daraprim against experimental toxoplasmosis in the mouse. Antibiot Chemother 1953;3:483-90.
11. Derouin F, Chastang C. In vitro effects of folate inhibitors on Toxoplasma gondii. Antimicrob Agents Chemother 1989;33:1753-9.
12. De Gans J, Portegies P, Reiss P, Troost D, Van Gool T, Lange JMA. Pyrimethamine alone as maintenance therapy for central nervous system toxoplasmosis in 38 patients with AIDS. J Acquir Immune Defic Syndr 1992;5:137-42.
13. Frenkel JK, Hitchings GH. Relative reversal by vitamins (p-aminobenzoic, folic and folinic acids) of the effects of sulfadiazine and pyrimethamine on Toxoplasma in mouse and man. Antibiot Chemother 1957;7:630-8.
14. Centers for Disease Control. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987; 36(1S):3-15.
15. Hardy WD, Feinberg J, Finkelstein DM, et al. A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med 1992;327:1842-8.
16. Leport C, Meulemans A, Robine D, Dameron G, Vildé JL. Levels of pyrimethamine in serum and penetration into brain tissue in humans. AIDS 1992;6:1040-1.