Effect of E2 envelope glycoprotein cytoplasmic domain mutations on Sindbis virus pathogenesis

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 1255-1260

  Levine, Beth ^a   Jiang, Hui Hui ^a   Kleeman, Linda ^a   Yang, Grace ^a  

^a The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; NONHUMAN; PRIORITY JOURNAL; SINDBIS VIRUS; VIROGENESIS; VIRUS ASSEMBLY; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 9044241680     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.1255-1260.1996     Document Type: Article

References (33)

1. Collier, N. C., S. P. Adams, H. Weingarten, and M. J. Schlesinger. 1992. Inhibition of enveloped RNA virus formation by peptides corresponding to glycoprotein sequences. Antivir. Chem Chemother 3:31-36.
2. Davis, N. L., F. J. Fuller, W. G. Dougherty, R. A. Olmsted, and R. E. Johnston. 1986. A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice. Proc Natl. Acad. Sci. USA 83:6771-6775.
3. Gaedigk-Nitschko, K., and M. J. Schlesinger. 1991. Site-directed mutations in Sindbis virus E2 glycoprotein's cytoplasmic domain and the 6K protein lead to similar defects in virus assembly and budding Virology 183:206-214.
4. Griffin, D. E. 1989 Molecular pathogenesis of Sindhis virus encephalitis in experimental animals. Adv Virus Res 36:225-271
5. Heidner, H. W., and R. E. Johnston. 1994 The amino-terminal residue of Sindbis virus glycoprotein E2 influences virus maturation, specific infectivity for BHK cells, and virulence in mice. J. Virol. 68:8064-5070.
6. Hertz, J. M., and H. V. Huang. 1992. Utilization of heterologous alphavirus junction sequences as promoters by Sindbis virus. J. Virol. 66:857-864.
7. Ivanova, L., S. Lustig, and M. J. Schlesinger. 1995. A pseudorevertant of a Sindbis virus 6K. protein mutant, which corrects for aberrant particle formation, contains two new mutations that map to the ectodomain of the E2 glycoprotein Virology 206:1027-1034.
8. Ivanova, L., and M. J. Schlesinger. 1993. Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding. J. Virol. 67:2546-2551.
9. Kail, M., M. Hollinshead, W. Ansorge, R. Pepperkok, R. Frank, G. Griffiths, and D. Vaux. 1991. The cytoplasmic domain of alphavirus E2 glycoprotein contains a short linear recognition signal required for viral budding EMBO J 10:2343-2351.
10. Levine, B., and D. E. Griffin. 1993. Molecular analysis of neurovirulent strains of Sindbis virus that evolve during persistent infection of scid mice. J. Virol 67:6872-6875
11. Levine, B., J. M. Hardwick, B. D. Trapp, T. O. Crawford, R. C. Bollinger, and D. E. Griffin. 1991. Antibody-mediated clearance of alphavirus infection from neurons. Science 254:856-860.
12. Liu, N., and D. T. Brown. 1993. Phosphorylation and dephosphorylation events play critical role in Sindbis virus maturation. Virology 196:703-711.
13. Lopez, S., J.-S. Yao, R. J. Kuhn, E. G. Strauss, and J. H. Strauss. 1994. Nucleocapsid-glycoprotein interactions required for alphavirus assembly. J. Virol. 68:1316-1323.
14. Lustig, S., M. Halevy, D. Ben-Nathan, and Y. Akov. 1992. A novel variant of Sindbis virus is both neurovirulent and neuroinvasive in adult mice. Arch. Virol. 122:237-248
15. Lustig, S. A., A. C. Jackson, C. S. Hahn, D. E. Griffin, E. G. Strauss, and J. H. Strauss. 1988. The molecular basis of Sindbis virus neurovirulence in mice. J Virol. 62:2329-2336.
16. Metsikkö, K., and H. Garoff. 1990. Oligomers of the cytoplasmic domain of the p62/E2 membrane protein of Semliki Forest virus bind to the nucleo-capsid in vitro J. Virol. 64:4678-4683.
17. Olmsted, R. A., W. J. Meyer, and R. E. Johnston. 1986. Characterization of Sindbis virus epitopes important for penetration in cell culture and pathogenesis in animals. Virology 148:245-254.
18. Polo, J. M., N. L. Davis, C. M. Rice, H. V. Huang, and R. E. Johnston. 1988. Molecular analysis of Sindbis virus pathogenesis in neonatal mice by using virus recombinants constructed in vitro. J Virol. 62:2124-2133.
19. Polo, J. M., and R. E. Johnston. 1990. Attenuating mutations in glycoproteins E1 and E2 of Sindbis virus produce a highly attenuated strain when combined in vitro. J. Virol. 64:4438-4444
20. Polo, J. M., and R. E. Johnston. 1991. Mutational analysis of a virulence locus in the E2 glycoprotein gene of Sindbis virus. J. Virol. 65:6358-6361.
21. Rice, C. M., and J. H. Strauss. 1981. Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins. Proc. Natl. Acad Sci USA 78:2062-2066
22. Rice, C. M., and J. H. Strauss. 1982. Isolation and characterization of the hydrophobic COOH-terminal domains of the Sindhis virion glycoproteins J. Mol. Biol 15-4:355-378.
23. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc Natl. Acad. Sci. USA 74:5463-5467.
24. Schmaljohn, A. L., E. D. Johnson, J. M. Dalrymple, and G. A. Cole. 1982. Nonneutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis Nature (London) 297:70-72.
25. Schoepp, R. J., and R. E. Johnston. 1993. Directed mutagenesis of a Sindbis virus pathogenesis site. Virology 193:149-159
26. Strauss, E. G., and J. H. Strauss. 1986. Structure and replication of the alphavirus. genome, p. 35-90. In S Schlesinger and M. J. Schlesinger (ed.). The Togaviridae and Flaviviridae. Plenum Publishing Corp., New York
27. Strauss, J. H., and E. G. Strauss. 1994. The alphaviruses: gene expression, replication, and evolution. Microbiol. Rev. 58:491-562.
28. Tucker, P. C., and D. E. Griffin. 1991. The mechanism of altered Sindbis virus neurovirulence associated with a single amino acid change in the E2 glycoprotein. J. Virol. 65:1551-1557
29. Tucker, P. C., E. G. Strauss, R. J. Kuhn, J. H. Strauss, and D. E. Griffin. 1993. Viral determinants of age-dependent virulence of Sindbis virus for mice. J. Virol. 67:4605-4610
30. Ubol, S., and D. E. Griffin. 1991. Identification of a putative alphavirus receptor on mouse neural cells. J. Virol. 65:6913-6921.
31. Ubol, S., B. Levine, S.-H. Lee, N. S. Greenspan, and D. E. Griffin. 1995 Role of immunoglobulin valency and the heavy-chain constant domain in antibody-mediated downregulation of Sindbis virus replication in persistently infected neurons. J. Virol 69:1990-1993
32. Wang, L., A. L. Schmaljohn, R. J. Kuhn, and J. H. Strauss. 1991 Antidio-typic antibodies as probes for the Sindbis virus receptor. Virology 181:694-702
33. Zhao, H., B. Lindqvist, H. Garoff, C.-H. von Bonsdorff, and P. Liljestrom. 1994. A tyrosine-based motif in the cytoplasmic domain of the alphavirus envelope glycoprotein is essential for budding. EMBO J. 13:42114-4211