Specific and effective interaction of a guanine nucleotide analogue with small G proteins

Molecular Pharmacology

Volumn 49, Issue 1, 1996, Pages 156-164

  Hoffenberg, Simon ^c   Shannon, Timothy M ^a   Noonan, Timothy P ^b   Liu, Shaobin ^c   Daniel, D Sundarsingh ^c   Fishman, Jordan B ^b   Rubins, Jeffrey B ^a   Misra, Hemant K ^b   Wright, George E ^b   Dickey, Burton F ^c,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 N (4 BUTYLPHENYL)GUANOSINE 5' (BETA,GAMMA DIFLUOROMETHYLENE)TRIPHOSPHATE; ACICLOVIR TRIPHOSPHATE; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' (BETA,GAMMA DIFLUOROMETHYLENE)TRIPHOSPHATE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE DERIVATIVE; GUANYLYLIMIDODIPHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; MOLECULAR RECOGNITION; MOLECULAR STABILITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; BLOTTING, WESTERN; CATTLE; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDES; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 9044239668     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Bourne, H. R., D. A. Sanders, and F. McCormick. The GTPase superfamily: conserved structure and molecular mechanism. Nature (Lond.) 349:117-127 (1991).
2. Dickey, B. F., and L. Birnbaumer, eds. GTPases in Biology. Springer-Verlag, Heidelberg (1993).
3. αL: more to view than just ras. Cell 76:201-204 (1994).
4. Joyce-Brady, M., J. B. Rubins, M. P. Panchenko, J. Bernardo, M. P. Steele, L. Kolm, E. R. Simons, and B. F. Dickey. Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells. J. Biol. Chem. 266:6859-6865 (1991).
5. Northup, J. K., M. D. Smigel, and A. G. Gilman. The guanine nucleotide activating site of the regulatory component of adenylate cyclase: identification by ligand binding. J. Biol. Chem. 257:11416-11423 (1982).
6. Kelleher, D. J., L. W. Dudycz, G. E. Wright, and G. L. Johnson. Ability of guanine nucleotide derivatives to bind and activate bovine transducin. Mol. Pharmacol. 30:603-607 (1986).
7. Arabshahi, L., N. Khan, M. Butler, T. Noonan, N. Brown, and G. Wright. (Difluoromethylene)phosphates of guanine nucleotides as probes of DNA polymerases and G proteins Biochemistry 29:6820-6826 (1990).
8. Blackburn, G. M., D. E. Kent, and F. J. Kolkmann. The synthesis and metal binding characteristics of novel, isopolar phosphate analogues of nucleotides. J. Chem. Soc. Perkins Trans. I. 1119-1125 (1984).
9. Noonan, T., N. Brown, L. Dudycz, and G. E. Wright. Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins. J. Med. Chem. 34:1302-1307 (1991).
10. Dexter, D., J. B. Rubins, E. C. Manning, L. Khachatrian, and B. F. Dickey. Compartmentalization of low molecular mass GTP-binding proteins among neutrophil secretory granules. J. Immunol. 145:1845-1850 (1990).
11. Hoffenberg, S., J. S. Sanford, S. Liu, D. S. Daniel, M. Tuvin, B. J. Knoll, M. Wessling-Resnick, and B. F. Dickey. Biochemical and functional characterization of a recombinant GTPase, Rab5, and two of its mutants. J. Biol. Chem. 270:5048-5056 (1995).
12. Goody, R. S., M. Frech, and A. Wittinghofer. Affinity of guanine nucleotide binding proteins for their ligands: facts and artifacts. Trends Biochem. Sci. 16:327-328 (1991).
13. Rensland, H., J. John, R. Linke, I. Simon, I. Schlichting, A. Wittinghofer, and R. S. Goody. Substrate and product structural requirements for binding of nucleotide to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides. Biochemistry 34:593-599 (1995).
14. Ojo-Amaize, E. A , B. Rubalcava, T. L. Avery, H. B. Cottam, S. S. Matsumoto, W. B. Jolley, and R. K. Robins. Activation of the respiratory burst in murine phagocytes by certain guanine ribonucleosides modified at the 7 and 8 positions: possible involvement of a pertussis toxin-sensitive G-protein. Immunol. Lett. 23:173-178 (1990).
15. Hingorani, V. T., L.-F. H. Chang, and Y.-K. Ho. Chemical modification of bovine transducin: probing the GTP-binding site with affinity analogues. Biochemistry 28:7424-7432 (1989).
16. John, J., R. Sohmen, J. Feuerstein, R Linke, A. Wittinghofer, and R. S. Goody Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 29:6058-6065 (1990).
17. NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein, use of a single fluorescent probe at the catalytic site. Proc. Natl. Acad. Sci. USA 87:3562-3565 (1990).
18. Hoyer, P. B., P. Fletcher, and B. E. Haley. Synthesis of 2′,3′-O-(2,4,6-trinitrocycloheadienylidine) guanosine 5′-triphospnate and a study of its inhibitory properties with adenylate cyclase. Arch. Biochem. Biophys. 245: 369-378 (1986).
19. Kim, S.-H, G G. Privé, and M. V. Milburn. Conformational switch and structural basis for oncogenic mutations of Ras proteins, in GTPases in Biology (B. F. Dickey and L. Birnbaumer, eds.). Springer-Verlag, Heidelberg, 177-194 (1993).
20. Stenmark, H., A Valencia, O. Martinez, O. Ullrich, B Goud., and M. Zerial. Distinct structural elements of rab5 define its functional specificity. EMBO J. 13:575-583 (1994).
21. Kabcenell, A. K., B. Boud, J. Northup, and P J. Novick. Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic. J. Biol Chem. 265:9366-9372 (1990).
22. Hiratsuka, T. A chromophoric and fluorescent analogue of GTP, 2′,3′-O-(2,4,6-trinitrocycloheadienylidene)-GTP, as a spectroscopic probe for the GTP inhibitory site of liver glutamate dehydrogenase. J. Biol. Chem. 260:4784-4790 (1985).
23. Kahn, R. Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins. J. Biol. Chem. 266:15595-15597 (1991).
24. lα1 and the mechanism of GTP hydrolysis Science (Washington D. C.) 265:1405-1412 (1994).
25. H preserves crucial kinetic and structural properties. J. Biol. Chem. 264:13086-13092 (1989).
26. Pai, E. F., U. Krengel, G. A. Petsko, R. S. Goody, W. Kabsch, and A. Wittinghofer. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 9:2351-2359 (1990).
27. Chambers, R. D., D O'Hagan, R. B. Lamont, and S. C. Jain. The difluoromethylenephosphonate moiety as a phosphate mimic: X-ray structure of 2-amino-1,1-difluoromethylphosphonic acid. J. Chem. Soc. Chem. Commun. 15:1053-1054 (1990).
28. ras. Biochemistry 32:7367-7376 (1993).
29. Campbell-Burk, S. L., and T. E. Van Aken. Analysis of ras structure and dynamics by nuclear magnetic resonance, in GTPases in Biology (B. F. Dickey and L. Birnbaumer, eds.). Springer-Verlag, Heidelberg, 213-234 (1993).
30. Yount, R. G , D. Babcock, W. Ballantyne, and D. Ojala. Adenylyl imidodiphosphate, an adenosine triphosphate analogue containing a P-N-P linkage. Biochemistry 10:2484-2489 (1971).
31. Lad, P. M., T B. Nielsen, M. S. Preston, and M. M. Rodbell. The role of the guanine nucleotide exchange reaction in the regulation of the β-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocytes. J. Biol. Chem. 255:988-995 (1980).
32. Fields, T. A., M. E. Linder, and P. J. Casey. Subtype-specific binding of azidoanilido-GTP by purified G protein α subunits. Biochemistry 33:6877-6883 (1994).
33. Valencia, A., P. Chardin, A. Wittinghofer, and C. Sander. The ras protein family: evolutionary tree and role of conserved amino acids. Biochemistry 30:4637-4648 (1991).