Increased risk of cardiovascular disease with erythropoietin in chronic dialysis patients

Nephron

Volumn 72, Issue 1, 1996, Pages 30-36

  Iseki, Kimitoshi ^a   Nishime, Keizo ^c   Uehara, Uajime ^d   Tokuyama, Kiyoyuki ^e   Toma, Shigeki ^f   Yoshihara, Kunio ^g   Kowatari, Temo ^h   Terukina, Shigeharu ⁱ   Osawa, Akira ^b   Fukiyama, Koshiro ^a  

^a Third Department of Internal Medicine and Research Center of Comprehensive Medicine   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

^c Okinawa Kyodo Hospital   (Japan)

^d Okinawa Prefectural Chubu Hospital   (Japan)

^e Sleep Respiratory Center   (Japan)

^f Naha City Hospital   (Japan)

^g Okinawa Dai ichi Hospital   (Japan)

^h Makiminato Chuo Hospital   (Japan)

ⁱ Okinawa Prefectural Naha Hospital Okinawa   (Japan)

Author keywords

Dialysis patients; Erythropoietin; Myocardial infarction; Stroke

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ACUTE HEART INFARCTION; ADULT; ARTICLE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; FEMALE; HEMODIALYSIS; HUMAN; INCIDENCE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK; STROKE;

CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; DIABETES MELLITUS; ERYTHROPOIETIN; FEMALE; HUMANS; JAPAN; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; RENAL DIALYSIS; RISK FACTORS;

EID: 9044232868     PISSN: 16608151     EISSN: 22353186     Source Type: Journal    
DOI: 10.1159/000188803     Document Type: Article

References (33)

1. Eschbach JW. Egrie J. Downing M, Browne J. Adamson J: Correction of anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 1987;316:73-78.
2. Esehbaeh JW. Adamson J W: Hematologic consequences of renal failure; in Brenner BM. Rector FC Jr(eds): The Kidney, ed-4. Philadelphia. Saunders, 1991. pp 2025-2026.
3. Hull AR. Parker TF III: Introduction and summary. Morbidity. Mortality and Prescription of Dialysis Symp. Dallas, Sept 1989. Am J Kidney Dis 1990:15:375-383.
4. Collins AJ. Hanson G, Umen A. Kjellstrand C. Keshaviah P: Changing risk factor demographics in end-stage renal disease patients entering hemodialysis and the impact on long-term mortality. Am J Kidney Dis 1990:15:422-432.
5. Iseki K. Kawazoe N. Osawa A. Fukiyama K: Survival analysis of dialysis patients in Okinawa. Japan (1971-1990). Kidney Int 1993:43: 404-409.
6. Raine AEG: Hypertension, blood viscosity, and cardiovascular morbidity in renal disease: Implications of erythropoietin therapy. Lancet 1988;Vol i:97-100.
7. Taylor JH. Belch JJ F. McLaren M. Henderson IS, Stewart WK: Effect of erythropoietin therapy and withdrawal in blood coagulation and fibrinolysis in hemodialysis patients. Kidney Int 1993:44:182-190.
8. Kännel WB. McGee D. Gordon T: A general cardiovascular risk profile: The Framingham study. Am J Cardiol 1976:38:46-51.
9. Eschbach JW. Abdulhadi Mil, Browne JK. Delano BG. Downing MR. Egrie JC. Evans RW, Friedman EA. Gräber SE. Haley R. Korbet S. Krantz SB. Lundin AP. Nissenson AR. Ogden DA. Paganini EP, Rader B. Rutsky EA. Stivel-man J. Stone WJ. Teschan P. Van Stone JC. Van Wyck DB, Zuckerinan K. Adamson JW: Recombinant human erythropoietin in anemic patients with end-stage renal disease. Results of a phase III multicenter clinical trial. Ann Intern Med 1989;111:992-1000.
10. Powe NR. Griffiths RI, Watson AJ, Anderson GF. deLissovoy G. Greer JW. Herbert RJ. Milam RA, Whelton PK: Effect of recombinant erythropoietin on hospital admissions, read-missions, length of stay, and costs of dialysis patients. J Am Soc Nephrol 1994:4:1455-1465.
11. Iseki K. Kinjo K, Kimura Y. Osawa A. Fukiva-ma K: Evidence for high risk of cerebral hemorrhage in chronic dialysis patients. Kidney Int 1993:44:1086-1090.
12. Iseki K. Kawazoe N. Fukiyama K: Serum albumin is a strong predictor of death in chronic dialysis patients. Kidney Int 1993:44:115-119.
13. Kinjo K. Kimura Y, Shinzalo Y, Tomori M. Komine Y. Kawazoe N, Takishita S. Fukiyama K. COSMO group: An epidemiological analysis of cardiovascular disease in Okinawa. Japan. Hypertens Res 1992:15:111-119.
14. Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959:22:719-748.
15. Eschbach JW: Erythropoietin: The promise and the facts. Kidney Int 1994;45(suppl 44): 70-76.
16. Earle K. Walker J, Hill C. Viberti G: Familial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathy. N Engl J Med 1992:326:673-677.
17. Manske CL. Thomas W. Wang Y. Wilson RF: Screening diabetic transplant candidates for coronary artery disease: Identification of a low risk subgroup. Kidney Int 1993:44:617-621.
18. Vincenti F. Amend WJ. Abele J. Fcduska NJ. Salvatierra O: The role of hypertension in hemodialysis-associated atherosclerosis. Am J Med 1980;68:363-369.
19. Lowric EG. Lew NL: Death risk in hemodialysis patients: The predictive values of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 1990:15:458-482.
20. Degoulet P, Legrain M. Reach I. Aime F. Devries C, Rojas P, Jacobs C: Mortality risk factors in patients treated by chronic hemodialysis. Report of the Diaphane collaborative study. Nephron 1982:31:103-110.
21. Bagdade JD, Porte D Jr. Bierman EL: Hypertriglyceridemia. A metabolic consequence of chronic renal failure. N Engl J Med 1968:279: 181-185.
22. Goldberg AP. Harter HR. Patsch W. Schecht-man KB. Province M. Weerts C. Kuisk I. McCratc MM. Schonfeld G: Racial differences in plasma high-density lipoproteins in patients receiving hemodialysis. A possible mechanism for accelerated atherosclerosis in w hite men. N Engl J Med 1983:308:1245-1252.
23. Lindner A, Cliarra B. Sherrard DJ, Scribner BIT Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;290:697-701.
24. Rostand SG. Kirk KA. Rutsky EA: The epidemiology of coronary artery disease in patients on maintenance hemodialysis: Implications for management; in Wizemann V, Kramer W. Schütterle G (eds): The Heart in End-Stage Renal Failure. Contrib Nephrol. Basel. Karger. 1986, vol 52. pp 34-41.
25. Rostand SG. Gretes JC. Kirk KA. Rutsky EA, Andreoli TE: Ischemic heart disease in patients with uremia undergoing maintenance hemodialysis. Kidney Int 1979:16:600-611.
26. Brott T. Thalinger K, Hertzberg V: Hypertension as a risk factor for spontaneous intracranial hemorrhage. Stroke 1986:17:1078-1083.
27. Vertes V. Cangiano JL. Berman LB. Gould A: Hypertension in end-stage renal disease. N Engl J Med 1969:280:978-981.
28. Charra B. Calemard E, Cuche M. Laurent G: Control of hypertension and prolonged survival on maintenance hemodialysis. Nephron 1983:33:96-99.
29. Charra B. Calemard E, Ruffet M. Chazot C, Terrât JC. Vancl T. Laurent G: Survival as an index of adquacy of dialysis. Kidney Int 1992: 41:1286-1291.
30. Macdougall IC. Lewis NP. Saunders MJ. Coch-lin DL, Davies ME. Hutton RD: Long-term cardiorespiratory effects of amelioration of renal anemia by erythropoietin. Lancet 1990: 335:489-493.
31. Fellner SK. Lang RM. Neumann A. Korcarz C. Botow KM: Cardiovascular consequences of correction of the anemia of renal failure with erythropoietin. Kidney Int 1993:44:1309-1315.
32. Mayer G. Thum J. Cada EM. Stummvoll HK. Graf H: Working capacity is increased following recombinant human erythropoietin treatment. Kidney Int 1988;34:525-528.
33. Marsh JT. Brown WS. Wolcott D, Carr CR, Harper R. Schweitzer SV, Nissenson AR: rlluEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int 1991:39:155-163.