Randomised trial of four-drug vs less intensive two-drug chemotherapy in the palliative treatment of patients with small-cell lung cancer (SCLC) and poor prognosis

British Journal of Cancer

Volumn 73, Issue 3, 1996, Pages 406-413

  Girling, D J ^a   Blechen, N M ^b   Bolger, J J ^b   Clark, P I ^b   Connolly, C K ^b   Hasleton, P S ^b   Hopwood, P ^b   Macbeth, F R ^b   Machin, D ^b   Moghissi, K ^b   Saunders, M I ^b   Stephens, R J ^b   Thatcher, N ^b   White, R J ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b NONE

Author keywords

Chemotherapy; Lung cancer; Palliative treatment; Quality of life; Randomised trial; Small cell lung cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; ETOPOSIDE; METHOTREXATE; VINCRISTINE;

ADULT; AGED; ALOPECIA; ANEMIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISTRESS SYNDROME; DYSPHAGIA; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NAUSEA; ORAL DRUG ADMINISTRATION; PALLIATIVE THERAPY; PARESTHESIA; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTOPENIA; TREATMENT OUTCOME; VOMITING;

EID: 9044227618     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.71     Document Type: Article

References (23)

1. COMPACT STEERING COMMITTEE (1991). Improving the quality of clinical trials in cancer. Br. J. Cancer, 63, 412-415.
2. DE HAES JCJ, KNIPPENBERG FCE AND NEIJT JP. (1990). Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br. J. Cancer, 62, 1034-1038.
3. EARL HM, RUDD RM, SPIRO SG, ASH CM, JAMES LE, LAW CS, TOBIAS JS, HARPER PG, GEDDES DM, ERAUT D, PARTRIDGE MR AND SOUHAMI RL. (1991). A randomised trial of planned versus as required chemotherapy in small cell lung cancer: a Cancer Research Campaign trial. Br. J. Cancer, 64, 566-572.
4. FAYERS PM, BLEEHEN NM, GIRLING DJ AND STEPHENS RJ. (1991). Assessment of quality of life in small-cell lung cancer using a daily diary card developed by the Medical Research Council Lung Cancer Working Party. Br. J. Cancer, 64, 299-306.
5. FRITH L. (1992). Quality of Life as Assessed by the Rotterdam Symptom Checklist in Patients with Lung Cancer. MSc thesis, University of Southampton.
6. GANZ PA, HASKELL CM, FIGLIN RA, LA SOTO N AND SIAU J, FOR THE UCLA SOLID TUMOR STUDY GROUP (1988). Estimating the quality of life in a clinical trial of patients with metastatic lung cancer using the Karnofsky performance status and the functional living index-cancer. Cancer, 61, 849-856.
7. HANSEN HH. (1992). Management of small cell cancer of the lung. Lancet, 339, 846-849.
8. HOPWOOD P, STEPHENS RJ AND MACHIN D. (1994). Approaches to the analysis of quality of life data: experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial. Quality of Life Research, 3, 339-352.
9. HOPWOOD P AND STEPHENS RJ, ON BEHALF OF THE MEDICAL RESEARCH COUNCIL (MRC) LUNG CANCER WORKING PARTY (1995). Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. Br. J. Cancer, 71, 633-636.
10. MACHIN D AND CAMPBELL MJ. (1987). Statistical Tables for the Design of Clinical Trials.. Table 4.1. Blackwell Scientific Publications: Oxford.
11. MEDICAL RESEARCH COUNCIL LUNG CANCER WORKING PARTY (1989a). Survival, adverse reactions and quality of life during combination chemotherapy compared with selective palliative treatment for small-cell lung cancer. Respir. Med., 83, 51-58.
12. MEDICAL RESEARCH COUNCIL LUNG CANCER WORKING PARTY (1989b). Controlled trial of twelve versus six courses of chemotherapy in the treatment of small-cell lung cancer. Br. J. Cancer, 59, 584-590.
13. MEDICAL RESEARCH COUNCIL LUNG CANCER WORKING PARTY (1993a). A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC) I: survival and prognostic factors. Br. J. Cancer, 68, 1150-1156.
14. MEDICAL RESEARCH COUNCIL LUNG CANCER WORKING PARTY (1993b). A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC) II: quality of life. Br. J. Cancer, 68, 1157-1166.
15. MORGAN DAL, GILSON D AND FLETCHER L. (1987). Vincristine and etoposide: an effective chemotherapy regimen with reduced toxicity in extensive small-cell lung cancer. Eur. J. Cancer Clin. Oncol., 23, 619-621.
16. MORITTU L, EARL HM, SOUHAMI RL, ASH CM, TOBIAS JS, GEDDES DM, HARPER PG AND SPIRO SG. (1989). Patients at risk of chemotherapy-associated toxicity in small cell lung cancer. Br. J. Cancer, 59, 801-804.
17. SLEVIN ML, PLANT H, LYNCH D, DRINK WATER J AND GREGORY WM. (1988). Who should measure quality of life, the doctor or patient? Br. J. Cancer, 57, 109-112.
18. STEPHENS RJ FOR THE BRITISH MEDICAL RESEARCH COUNCIL (MRC) LUNG CANCER WORKING PARTY (LCWP). (1994). Quality of life (QL) in randomised clinical trials: are the doctors' assessments as valid as the patients'? Lung Cancer, 11 (suppl. 1), 81, abstract 307.
19. STEPHENS RJ, GIRLING DJ, MACHIN D AND MEDICAL RESEARCH COUNCIL LUNG CANCER WORKING PARTY (1994). Treatment-related deaths in small cell lung cancer trials: can patients at risk be identified? Lung Cancer, 11, 259-274.
20. THOMAS J STJ, LAMB D, ASHCROFT T, CORRIN B, EDWARDS CW, GIBBS AR, KENYON WE, STEPHENS RJ AND WHIMSTER WP. (1993). How reliable is the diagnosis of lung cancer using small biopsy specimens? Report of a UKCCCR Lung Cancer Working Party. Thorax, 48, 1135-1139.
21. WORLD HEALTH ORGANIZATION (1979). WHO Handbook for Reporting Results of Cancer Treatment. WHO Offset Publication No. 48. WHO: Geneva.
22. WORLD HEALTH ORGANIZATION (1981). International Histological Classification of Tumours No. 1: Histological Typing of Lung Tumours, second edn. WHO: Geneva.
23. ZIGMOND AS AND SNAITH RR. (1983). The Hosptial Anxiety and Depression Scale. Acta Psychiatr. Scand., 67, 361-370.