Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats

Acta Physiologica Scandinavica

Volumn 157, Issue 2, 1996, Pages 253-258

  Wu, W ^a   Oshida, Y ^a   Yang, W P ^a   Li, L ^a   Ohsawa, I ^a   Sato, J ^a   Iwao, S ^a   Johansson, B L ^b   Wahren, J ^b   Sato, Y ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

C peptide; Diabetics; Euglycaemic clamp; Insulin action

Indexed keywords

C PEPTIDE; INSULIN; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 8944260416     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1996.489236000.x     Document Type: Article

References (19)

1. Akpan, J.O., Weide, L.G. & Gingerich, R.L. 1993. A specific and sensitive radioimmunoassay for rat C-peptide. Int J Pancreatol 13, 87-95.
2. Hoogwerf, B.J., Bantle, J.P., Gaenslen, H.E., Greenberg, B.Z., Senske, B.J., Francis, R. & Goetz, F.C. 1986. Influsion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects. Metabolism 35, 122-125.
3. Ido, Y., Allison, W.S., Chang, K., Faller, A.M. & Williamson, J.R. 1994. Effects of human and rat C-peptide on hyperglycemia induced vascular dysfunction. 15th International Diabetes Federation Congress, 6 11 November 1994, 480 (abstract).
4. Johansson, B-L., Sjöberg, S. & Wahren, J. 1992a. The influence of human C-peptide on renal function and glucose utilization in Type 1 (insulin-dependent) diabetic patients. Diabetologia 35, 121-128.
5. Johansson, B-L., Linde, B. & Wahren, J. 1992b. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of Type 1 (insulin-dependent) diabetic patients. Diabetologia 35, 1151-1158.
6. Johansson, B-L., Kernell, A., Sjöberg, S. & Wahren, J. 1993. Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes Type 1. J Clin Endocrinol & Metab 77, 976-981.
7. Johansson, B-L., Huang, W., Sjoquist, M. & Wahren, J. 1994. Acute effects of human C-peptide on renal function in the early stage of experimental diabetes in rats. 15th International Diabetes Federation Congress, 6 11 November 1994, 480 (abstract).
8. Kahn, C.R. 1978. Insulin resistance, insulin insensitivity and insulin unresponsiveness: a necessary distinction. Metabolism 27, 1893-1902.
9. Kitabchi, A.E. 1970. The biological and immunological properties of pork and beef insulin, proinsulin and connecting peptides. J Clin Invest 49, 979-987.
10. Nishimura, H., Kuzuya, H., Okamoto, M., Yamada, K., Kosaki, A., Kakei, T., Inoue, G., Kono, S. & Imura, H. 1989. Postreceptor defect in insulin action in streptoxotocin induced diabetic rats. Am J Physiol 256, E624-E630.
11. +ATPase activity. Kidney Int 45, 1606-1613.
12. +ATPase activity in synergism with neuropeptide Y. Diabetologia 39, 199-205.
13. Oshida, Y., Ohsawa, I., Sato, J. & Sato, Y. 1993. Effects of adrenodemedullation on in vivo insulin-stimulated glucose utilization in relation to glycolysis in rat peripheral tissue. Endocr J 40, 99-106.
14. Olefsky, J.M., Kolterman, O.G. & Scarlett, J.A. 1982. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol 143, E15-E30.
15. Rubenstein, A.H., Clark, J.L., Melani, F. & Steiner, D.F. 1969. Secretion of proinsulin C-peptide by pancreatic B cell and its circulation in blood. Narture 224, 697-699.
16. Sato, J., Ohsawa, I., Oshida, Y., Sato, Y. & Sakamoto, N. 1993. Effects of glimepride on in vivo insulin action in normal and diabetic rats. Diabetes Res Clin Pract 22, 3-9.
17. Yang, W-P., Oshida, Y., Wu, W., Sato, J., Ohsawa, I. & Sato, Y. 1995. Effect of daily voluntary running on in vivo insulin action in rat skeletal muscle and adipose tissue as determined by the microdialysis technique. Int J Sports Med 16, 99-104.
18. Zierath, J.R., Galuska, D., Johansson, B-L. & Wallberg-Henriksson, H. 1991. Effect of human C-peptide on glucose transport in vitro incubated human skeletal muscle. Diabetologia 34, 899-901.
19. Zieruth, J.R., Thörne, A., Johansson, B-L. & Wallberg-Henriksson, H. 1990. C-peptide stimulates glucose transport in type 1 diabetic skeletal muscle. Diabetologia 33 (Suppl.), A226 (Abstract).