Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18

International Immunology

Volumn 8, Issue 7, 1996, Pages 1165-1172

  Saito, Hidetsugu ^a   Kurose, Iwao ^a   Ebinuma, Hirotoshi ^a   Fukumura, Dai ^a   Higuchi, Hajime ^a   Atsukawa, Kazuhiro ^a   Tada, Shinichiro ^a   Kimura, Hiroyuki ^a   Yonei, Yoshikazu ^a   Masuda, Tetsuya ^a   Miura, Soichiro ^a   Ishii, Hiromasa ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

CD18; Confocal microscopy; Cytotoxicity; Flow cytometry; ICAM 1; Kupffer cell; Nitric oxide; Nitric oxide synthase

Indexed keywords

CD18 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; RHODAMINE 123; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; CYTOMETRY; CYTOTOXICITY; ENZYME ACTIVITY; FLUORESCENCE; HEPATOMA CELL; KUPFFER CELL; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIGENS, CD18; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL ADHESION MOLECULES; CYTOTOXICITY, IMMUNOLOGIC; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; INTERLEUKIN-1; KUPFFER CELLS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NITRIC OXIDE; RATS; RATS, INBRED STRAINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 8944249287     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.7.1165     Document Type: Article

References (38)

1. Keller, F., Wild, M. and Kim, A. 1984, In vitro cytostatic properties of unactivated at Kupffer cells. J. Leukocyte Biol 35:467.
2. Xu, Z. L., Bucana, C. D. and Filder, l. J. 1984. In vitro activation of murine Kupffer cells by lymphokines or endotoxins to lyse syngeneic tumor cells. Am. J Pathol. 117:372.
3. Kurose, I., Salto, H., Suematsu, M., Fukumura, D., Miura, S., Morizane, T. and Tsuchiya, M. 1991. Kupffer cell-mediated oxidative stress on colon cancer cell line visualized by digital imaging fluorescence microscopy. Cancer Lett. 59:201.
4. Yonei, Y, Kurose, I., Fukumura, D., Saito, H., Miura, S., Tsukada, N., Oda, M. and Tsuchiya, M. 1994. Evidence of direct interaction between Kupffer cells and colon cancer cells: an ultrastructural study of the co-culture. Liver 14:37.
5. Kuross, I., Miura, S., Fukumura, D., Yonei, Y, Saito, H., Tada, S., Suematsu, M. and Tsuchiya, M. 1993. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst. Cancer Res. 53:2676.
6. Saito, H., Morizane, T., Inagaki, Y., Kumagai, N., Watanabe, T., Nakamura, T., Satoh, I., Sawaguchi, K., Iwabuchi, N., Tsuchimoto, K. and Tsuchiya, M. 1989. Decrease of transplantability by the immunopotentiators, OK-432 and interleukin-2: experiments on a human hepatoma cell line in nude mice. Eur. J. Cancer 25:79.
7. Saito, H., Fukumura, D., Kurose, I., Suematsu, M., Tada, S., Kagawa, T., Miura, S., Morizane, T. and Tsuchiya, M. 1992. Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M. Int. J. Cancer 51:124.
8. Bouwens, L., Baekeland, M. and Wisse, M. 1984. Importance of local proliferation in the expanding Kupffer cell population of rat liver after zyrnosan stimulation and partial hepatectomy. Hepatology 4:21.
9. Roland, C. R., Walp, M., Stack, R. M. and Fly, W. 1994. Outcome of Kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFN-γ. J. Immunol. 153:5453.
10. Knook, D., Blansjaar, N. and Sleyster, E. 1977. Isolation and characterization of Kupffer and endothelial cells from the rat liver. Exp. Cell. Res. 109:317.
11. Drochmans, P., Wanson, J. C. and Mosselmans, R. 1975. Isolation and subfraction on Ficoll gradients of adult rat hepatocytes. Size, morphology, and biochemical characteristics of cell fractions. J. Cell. Biol. 66:1.
12. Saito, H., Tada, S., Ebinuma, H., Tsunematsu, S., Kagawa, T., Kurnagai, N., Inagaki, Y. Watanabe, T., Tsuchimoto, K., Morizane, T., Ishii, H. and Tsuchiya, M. 1994. Changes of antigen expression on human hepatoma cell lines caused by sodium butyrate, a differentiation inducer. J. Gastroenterol. 29:733.
13. Bartholomew, B. 1984. A rapid method for the assay of nitrate in urine using the nitrate reductase enzyme of Escherichia coli. Food Chem. Toxicol. 22:541.
14. 2+-independent nitric oxide synthethases. FEBS Lett. 291:145.
15. Knowles, R. G., Merrett, M., Salter, M. and Moncada, S. 1990. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270:833.
16. Dustin, M. L., Rothlein, R., Bhan, A. K., Dinnarello, C. A. and Springer, T. A. 1986. Induction by IL-1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245
17. Pober, J. S., Bevilacqua, M. P., Mendrick, D. L., Lapierre, L. A., Fiers, W. and Gimbrone, M. A., Jr. 1986. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J. Immunol. 136:1680.
18. Pober, J. S., Gimbrone, M. A., Jr, Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R. and Springer, T. A. 1986. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 137:1893.
19. Pober, J. S., Lapierre, L. A., Stolpen, A. H., Brock, T. A., Springer, T. A., Fiers, W., Bevilacqua, M. P., Mendrick, D. L, and Gimbrone, M. A., Jr. 1987. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J. Immunol. 138:3319.
20. Renkonen, R. 1989. Regulation of intercellular adhesion molecule1 expression on endothelial cells with correlation to lymphocyte-endothelial binding. Scand. J Immunol. 29:717.
21. Cotran, R. C., Gimbrone, M. A., Jr, Bevilacqua, M. P., Mendrick, D. L. and Pober, J. S. 1986. Induction and detection of a human endothelial activation antigen in vivo. J. Exp. Med. 164:661.
22. Figdor, C. G. and van Kooyk, Y. 1992. Regulation of cell adhesion. In Harlan, J. M. and Liu, D. Y., eds, Adhesion - Its Role in Inflammatory Disease, p. 151 W H. Freeman, New York.
23. Lepoivre, M., Fieschi, F., Coves, J., Thelander, H. and Fontecave, M. 1991. Inactivation of ribonucleotide reductase by nitric oxide. Biochem. Biophys. Res. Commun. 179:442.
24. Kwon, N. S., Stuehr, D. J. and Nathan, C. F. 1991. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med. 174:761.
25. Moncada, S. 1992. The L-arginine:nitric oxide pathway. Acta Physiol. Scand. 145:201.
26. Isobe, K. and Nakashima, I. 1993. Abundant production of nitric oxide from murine macrophages by direct stimulation of tumor cells. Biochem. Biophys. Res Commun. 192:499.
27. Aono, K., Isobe, K., Nakashima, I., Kondo, S., Miyachi M. and Nimura, Y. 1994. Kupffer cells cytotoxicity against hepatoma cells is related to nitric oxide. Biochem Biophys. Res. Commun. 201:1175.
28. Dransfield, I., Buckle, A. M. and Hogg, N. 1990. Early events of the immune response mediated by leukocyte integrins. Immunol. Rev. 114:29.
29. Chartrain, N. A., Geller, D. A., Koty, P. P., Sitrin. N. F., Nussler, A. K., Hoffman, E. P., Billiar, T. R., Hutchinson, N. I. and Mudgett, J. S. 1994. Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J. Biol. Chem, 269:6765.
30. Nathan, C. and Xie, Q.-W. 1994. Regulation of biosynthesis of nitric oxide, J. Biol. Chem. 269:13725.
31. Munokawa, Y., Ishida, N. and Tanaka, S. 1994. Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis Biochem. Biophys. Res. Commun. 200:802.
32. Kamijo, R., Harada, H., Matsuyama. T., Bosland, M., Gerecitano, J., Shapiro, D., Le. J., Koh, S. l., Kimura. T, Green, S. J., Mak, T. W., Taniguchi, T. and Vilcek, J. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612.
33. Goodrum, K. J., McCormick, L. L. and Schneider, B. 1994. Group B Streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent. Infect. Immun 62:3102.
34. Gurran, R. D., Ferrari, F. K., Kispert, P. H., Stadler, J., Stuehr, D. J., Simmons, R. L, and Billiar. T. R. 1991. Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis FASEB J. 5:2085.
35. Albina, J. E., Cui. S., Mateo, R. B. and Reichner, J. S. 1993. Nitric oxide-mediated apoptosis in murine peritoneal macrophage. J. Immunol. 150:5080.
36. Pou, S., Pou, W. S., Bredt, D. S., Snyder. S. H. and Rosen, G. M. 1992. Generation of Superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 267:24173.
37. 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase, Biochem. J 281:627
38. Ferrari, M., Fornasiero, M, C and Isetta, A. M. 1990. MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J. Immunol. Methods 131:165.