Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients

Journal of Lipid Research

Volumn 37, Issue 7, 1996, Pages 1569-1578

  Tilly Kiesi, Marju ^a   Knudsen, Petteri ^a   Groop, Leif ^a   Taskinen, Marja Riitta ^a   Nissen, Michael ^a   Forsen, Björn ^a   Snickars, Borje ^a   Ehrnström, Björn Olof ^a   Isomaa, Bo ^a   Lahti, Kaj ^a   Forsblom, Carol ^a   Tuomi, Tiinamaija ^a   Lehto, Markku ^a   Häggblom, Maja ^a   Akerma, Lisbeth ^a   Eklöf, Gudrun ^a   Paulaharju, Sonja ^a   Gullström, Monika ^a   Stenbeck, Inga Britt ^a   Salmela, Susanna ^a   Sarelin, Leena ^a   Heikkinen, Seija ^a   Parkkinen, Maja ^a   Laurila, Esa ^a   more..

^a NONE

Author keywords

cholesterol; HDL insulin; IDL; triglycerides; VLDL

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CHOLESTEROL BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; FAMILY; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 8944248822     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Reaven, G. M. 1988. Role of insulin resistance in human disease. Diabetes. 37: 1595-1607.
2. Howard, B. V., W. G. H. Abbott, G. Egussa, and M-R. Taskinen. 1987. Coordination of very low-density lipoprotein triglyceride and apolipoprotein B metabolism in humans: effects of obesity and non-insulin-dependent diabetes mellitus. Am. Heart. J. 113: 522-526.
3. Wiggins, D., and G. F. Gibbons. 1992. The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas. Biochem. J. 284: 457-462.
4. Taskinen, M-R. 1992. Quantitative and qualitative lipoprotein abnormalities in diabetes mellitus. Diabetes. 41 (Suppl. 2): 12-17.
5. Reaven, G. M., Y-D. Chen, and R. M. Krauss. 1992. Resistance to insulin-mediated glucose uptake and hyperinsulinemia in subjects with small, dense LDL. Circulation. 86 (Suppl): 1-73.
6. Reaven, G. M., Y-D. Chen, J. Jeppesen, P. Maheux, and R. M. Krauss. 1993. Insulin resistance and hyperinsulinemia in individuals with small, dense, low density lipoprotein particles. J. Clin. Invest. 92: 141-146.
7. Selby, J. V., M. A. Austin, B. Newman, D. Zhang, C. P. Quesenberry, E. J. Mayer, and R. M. Krauss. 1993. LDL subclass phenotypes and the insulin resistance syndrome in women. Circulation. 88: 381-387.
8. Schrezenmeir, J., I. Keppler, S. Fenselau, P. Weber, H. K. Biesalski, R. Probst, C. Laue, H. D. Zuchhold, W. Prellwitz, and J. Beyer. 1993. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. Ann. NY Acad. Sci. 683: 302-314.
9. Patsch, J. R., G. Miesenbock, T. Hopferweiser, V. Muhlberger, E. Knapp, J. K. Dunn, A. M. Gotto, and W. Patsch. 1992. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler. Thromb. 12: 1336-1345.
10. Mitchell, B. D., S. M. Haffner, H. P. Hazuda, R. Valdez, and M. P. Stern. 1992. The relation between serum insulin levels and 8-year changes in lipid, lipoprotein, and blood pressure levels. Am. J. Epidemiol. 136: 12-22.
11. Godsland, I. F., D. Crook, C. Walton, V. Wynn, and M. F. Oliver. 1992. Influence of insulin resistance, secretion, and clearance on serum cholesterol, triglycerides, lipoprotein cholesterol, and blood pressure in healthy men. Arterioscler. Thromb. 12: 1030-1035.
12. Laakso, M., H. Sarlund, and L. Mykkänen. 1990. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arterioscler. Thromb. 10: 223-231.
13. Garg, A., J. H. Helderman, M. Koffler, R. Ayuso, J. Rosenstock, and P. Raskin. 1988. Relationship between lipoprotein levels and in vivo insulin action in normal young white men. Metabolism. 37: 982-987.
14. Abbott, W. G., S. Lilloja, A. A. Young, J. K. Zawadzki, H. Yki-Järvinen, L. Christin, and B. V. Howard. 1987. Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population. Diabetes. 36: 897-904.
15. Laakso, M. 1993. How good a marker is insulin level for insulin resistance? Am. J. Epidemiol. 137: 959-965.
16. Orchard, T. J., D. J. Becker, M. Bates, L. H. Kuller, and A. L. Drash. 1983. Plasma insulin and lipoprotein concentrations: an atherogenic association? Am. J. Epidemiol. 118: 326-337.
17. Zavaroni, I., E. Dall'Aglio, O. Alpi, F. Bruschi, E. Bonora, A. Pezzarossi, and U. Butturini. 1985. Evidence for an independent relationship between plasma insulin and concentrations of high density lipoprotein cholesterol and triglyceride. Atherosclerosis. 55: 259-266.
18. Cambien, F., M. Warnet, E. Eschwege, J-L. Richard, and G. Rosselin. 1987. Body mass, blood pressure, glucose and lipids. Does plasma insulin explain their relationship? Arterioscler. Thromb. 7: 197-202.
19. Fontbonne, A., E. Eschwege, F. Cambien, J-L. Richard, P. Ducimetiere, N. Thibult, J-M. Warnet, J-R. Claude, and G-E. Rosselin. 1989. Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from the 11-year follow-up of the Paris Prospective Study. Diabetologia. 32: 300-304.
20. Schumacher, M. C., S. C. Hunt, T. M. Maxwell, R. R. Williams, and S. C. Elbein. 1992. Dyslipidemias among normoglycemic members of familial NIDDM pedigrees. Diabetes Care. 15: 1285-1289.
21. Eriksson, J., A. Franssila-Kallunki, A. Ekstrand, C. Saloranta, E. Widen, C. Schalin, and L. Groop. 1989. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 321: 337-343.
22. Gulli, G., E. Ferrannini, E. Stern, S. Haffner, and R. A. DeFronzo. 1992. Metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 41: 1575-1586.
23. Groop, L., C. Forsblom, M. Lehtovirta, M. Nissen, B-O. Ehrnström, B. Forsen, B. Isomaa, B. Snickars, and M-R. Taskinen. 1996. Metabolic consequences of a family history of NIDDM: the Botnia study. Diabetes. In press.
24. WHO Expert Committee on Diabetes Mellitus. Second Report. Geneva. Technical Report Series, No 646, 1980.
25. Griffin, B. A., M. J. Caslake, B. Yip, G. W. Tait, C. J. Packard, and J. Shepherd. 1990. Low density lipoprotein subfractions. Atherosclerosis. 83: 59-67.
26. Groot, P. H. E., L. M. Scheek, L. Havekes, W. L. van Noort, and F. M. van't Hooft. 1982. A one-step separation of human serum high density lipoproteins 2 and 3 by ratezonal density gradient ultracentrifugation in a swinging bucket rotor. J. Lipid Res. 23: 1342-1353.
27. Friedewald, W. T., R. I. Levy, and D. S. Fredrickson. 1972. Estimation of the concentrations of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin. Chem. 18: 499-502.
28. Taskinen, M-R. 1990. Hyperlipidemia in diabetes. In Bailliere's Clinical Endocrinology and Metabolism. Vol. 4. D. J. Betteridge, editor. Bailliere, Tindall, London. 743-775.
29. Mykkänen, L., J. Kuusisto, S. Haffner, K. Pyörälä, and M. Laakso. 1994. Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects. Arterioscler. Thromb. 14: 518-526.
30. DeFronzo, R. A., and E. Ferrannini. 1991. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care. 14: 173-194.
31. Haffner, S. M., R. A. Valdez, H. P. Hazuda, B. D. Mitchell, P. A. Morales, and M. P. Stern. 1992. Prospective analysis of the insulin-resistance syndrome (Syndrome X). Diabetes. 41: 715-722.
32. Taskinen, M-R., T. Kuusi, E. Helve, E. A. Nikkilä, and H. Yki-Järvinen. 1988. Insulin therapy induces antiatherogenic changes of serum lipoproteins in noninsulin-dependent diabetes. Arterioscler. Thromb. 8: 168-177.
33. James, R. W., and D. Pometta. 1991. The distribution profiles of very low density and low density lipoproteins in poorly controlled male, type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 34: 246-252.
34. Taskinen, M-R., C. J. Packard, and J. Shepherd. 1990. Effect of insulin therapy on metabolic fate of apolipoprotein B-containing lipoproteins in NIDDM. Diabetes. 39: 1017-1027.
35. Packard, C. J., A. Munro, R. Lorimer, A. M. Gotto, and J. Shepherd. 1984. Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects. J. Clin. Invest. 74: 2178-2194.
36. Griffin, B. A., D. J. Freeman, G. W. Tait, J. Thompson, M. J. Caslake, C. J. Packard, and J. Shepherd. 1994. Role of plasma triglyceride in regulation of low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis. 106: 241-253.
37. Watson, T. D. G., M. J. Caslake, D. J. Freeman, B. A. Griffin, J. Hinnie, C. J. Packard, and J. Shepherd. 1994. Determinants of LDL subfraction distribution and concentrations in young normolipidemic subjects. Arterioscler. Thromb. 14: 902-910.
38. Pykälistö, O. J., P. H. Smith, and D. J. Brunzell. 1975. Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes on basal- and diet-induced activity. J. Clin. Invest. 56: 1108-1117.
39. Kern, P. A., J. M. Ong, B. Saffari, and J. Carty. 1990. The effects of weight loss on the activity and expression of adipose-tissue lipoprotein lipase in very obese humans. N. Engl. J. Med. 322: 1053-1059.
40. Pollare, T., B. Vessby, and H. Lithell. 1991. Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity. Arteriosclerosis. 11: 1192-1203.
41. Knudsen, P., J. Eriksson, S. Lahdenperä, J. Kahri, L. Groop, M-R. Taskinen, and the Botnia Study Group. 1995. Changes of lipolytic enzymes cluster with insulin resistance syndrome. Diabetologia. 38: 48-54.
42. Chen, Y-D., F. Facchini, C. Landau, C. B. Hollenbeck, and G. M. Reaven. 1994. Plasma post-heparin lipoprotein lipase activity is decreased in normal individuals who are resistant to insulin-mediated glucose uptake. Endocrinol. Metab. 1: 153-158.
43. Ahn, Y. I., R. E. Ferrell, R. F. Hamman, and M. I. Kamboh. 1993. Association of lipoprotein lipase gene variation with the physiological components of the insulin-resistance syndrome in the population of the San Luis Valley, Colorado. Diabetes Care. 16: 1502-1506.
44. Stewart, M. W., M. F. Laker, R. G. Dyer, F. Game, J. Mitcheson, P. H. Winocour, and K. G. M. M. Alberti. 1993. Lipoprotein composition abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia. Arterioscler. Thromb. 13: 1046-1052.
45. Eisenberg, S., D. Gavish, Y. Oschry, M. Fainaru, and R. J. Deckelbaum. 1984. Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. J. Clin. Invest. 74: 470-482.
46. Tilly-Kiesi, M. 1991. The effect of lovastatin treatment on low-density lipoprotein hydrated density distribution and composition in patients with intermittent claudication and primary hypercholesterolemia. Metabolism. 40: 623-628.
47. McNamara, J. R., J. L. Jenner, Z. Li, P. W. F. Wilson, and E. J. Schaefer. 1992. Change in LDL particle size is associated with change in plasma triglyceride concentration. Arterioscler. Thromb. 12: 1284-1290.
48. Lahdenperä, S., T. Sane, H. Vuorinen-Markkola, P. Knudsen, and M-R. Taskinen. 1995. LDL particle size in mildly hypertriglyceridemic subjects: no relation to insulin resistance or diabetes. Atherosclerosis. 113: 227-236.
49. Tilly-Kiesi, M., M. Syvänne, T. Kuusi, S. Lahdenperä, and M-R. Taskinen. 1992. Abnormalities of low density lipoproteins in normolipidemic type II diabetic and nondiabetic patients with coronary artery disease. J. Lipid Res. 33: 333-342.
50. Tribble, D. L., L. G. Holl, P. D. Wood, and R. M. Krauss. 1992. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis. 93: 189-199.
51. de Graaf, J., J. C. Hendriks, P. N. Demacker, and A. F. Stalenhoef. 1993. Identification of multiple dense LDL subfractions with enhanged susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Arterioscler. Thromb. 13: 712-719.
52. Shepherd, J. 1993. Mechanism of action of fibrates. Postgrad. Med. J. 69: (Suppl. 1): S34-S41.
53. Nikkilä, E. A., M-R. Taskinen, and T. Sane. 1987. Plasma high-density concentration and subfraction distribution in relation to triglyceride metabolism. Am. Heart. J. 113: 543-548.
54. Patsch, J. R., S. Prasad, A. M. Gotto, Jr., and W. Patsch. 1987. High density lipoprotein 2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to activities of lipoprotein lipase and hepatic lipase. J. Clin. Invest. 80: 341-347.
55. Patsch, J. R., S. Prasad, A. M. Gotto, Jr., and G. Bengtsson-Olivecrona. 1984. Postprandial lipemia. A key for the conversion of high density lipoprotein 2 to high density lipoprotein 3 by hepatic lipase. J. Clin. Invest. 74: 2017-2023.
56. Kuusi, T., E. A. Nikkilä, M-R. Taskinen, and M. J. Tikkanen. 1982. Role of hepatic endothelial lipase in the metabolism of plasma HDL. Atherosclerosis. 44: 237-240.
57. Tall, A. R. 1993. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34: 1255-1274.
58. Dullaart, R. P. F., W. J. Sluiter, L. D. Dikkeschei, K. Hoogenberg, and A. van Tol. 1994. Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism. Eur. J. Clin. Invest. 24: 188-194.